Synthesis of an oligonucleotide-intercalator conjugate in which the linker chain is attached via the phenolic hydroxyl group of fagaronine

Tetrahedron Letters

Volumn 33, Issue 17, 1992, Pages 2275-2278

  Chen, Jer kang ^a,b   Carlson, Dean V ^a,b   Lee Weith, H ^a,b   O'Brien, Julie A ^b,c   Goldman, Mark E ^b,c   Cushman, Mark ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antisense; oligonucleotide intercalator conjugate, benzophenanthridine, fagaronine.

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; FAGARONINE; FAGARONINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DNA BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

EID: 0026552061     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)74188-8     Document Type: Article

References (20)

1. Antisense oligonucleotides: a new therapeutic principle
2. Inhibition of reverse transcriptase activity of RNA-tumor viruses by fagaronine
3. Selective reductions. XIX. Rapid reaction of carboxylic acids with borane-tetrahydrofuran. Remarkably convenient procedure for the selective conversion of carboxylic acids to the corresponding alcohols in the presence of other functional groups