Expression of the 64 kDa/glutamic acid decarboxylase rat islet cell autoantigen is influenced by the rate of insulin secretion

Diabetologia: Clinical and Experimental Diabetes and Metabolism

Volumn 35, Issue 5, 1992, Pages 490-493

  Bjork E ^a   Kampe O ^a   Andersson, A ^b   Karlsson, F A ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Autoantigen; diazoxide; glutamic acid decarboxylase; insulin secretion; islet cells

Indexed keywords

2 OXOISOCAPROIC ACID; DIAZOXIDE; GLIPIZIDE; GLUCOSE; GLUTAMATE DECARBOXYLASE; INSULIN;

ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT;

ANIMAL; AUTOANTIGENS; CELLS, CULTURED; DIAZOXIDE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLIPIZIDE; GLUCOSE; GLUTAMATE DECARBOXYLASE; INSULIN; ISLETS OF LANGERHANS; KETO ACIDS; KINETICS; MALE; METHIONINE; MOLECULAR WEIGHT; PROINSULIN; PROTEINS; RATS; RATS, INBRED WF; SULFUR RADIOISOTOPES; SUPPORT, NON-U.S. GOV'T;

EID: 0026551285     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF02342450     Document Type: Article

References (10)

1. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
2. High-glucose stimulation of 64,000-Mr islet cell autoantigen expression
3. Effects of sulfonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell-line
4. Anti-insulin serum coupled to sepharose 4B as a tool for the investigation of insulin biosynthesis in the β-cells of obese hyperglycemic mice
5. + channels in pancreatic β-cells
6. GABA and pancreatic β-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion
7. GABA in peripheral tissues: Presence and actions in endocrine pancreatic function
8. Glucose-inhibition of glucagon secretion involves activation of GABA-receptor chloride channels
9. Increased incidence of true type 1 diabetes acquired during pregnancy
10. A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus