Toxic effects of solstitialin a 13-acetate and cynaropicrin from Centaurea solstitialis L. (asteraceae) in cell cultures of foetal rat brain

Neuropharmacology

Volumn 31, Issue 3, 1992, Pages 271-277

  Cheng, C H K ^a   Costall, B ^a   Hamburger, M ^b   Hostettmann, K ^b   Naylor, R J ^a   Wang, Y ^b   Jenner, P ^c  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c Parkinson Disease Society Experimental Research Laboratories Pharmacology Group Biomedical Sciences Division ^*  (United Kingdom)

Author keywords

cynaropicrin; rat brain cell cultures; solstitialin A 13 acetate; yellow star thistle

Indexed keywords

CENTAUREA SOLSTITIALIS EXTRACT; CYNAROPICRIN; PLANT EXTRACT; SOLSTITIALIN 13 ACETATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; FETUS; FRONTAL CORTEX; MESENCEPHALON; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SUBSTANTIA NIGRA;

ANIMAL; BRAIN; CELLS, CULTURED; FEMALE; LACTONES; PLANT EXTRACTS; PLANTS; PREGNANCY; RATS; RATS, INBRED STRAINS; SESQUITERPENES;

EID: 0026551089     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(92)90177-Q     Document Type: Article

References (29)

1. + in rat neuronal and glial cell cultures
2. Comparison of yellow star thistle volatiles from different plant parts
3. Growth and differentiation of neural cells in defined media
4. Nigropallidal encephalomalacia in horses
5. + binds to neuromelanin
6. The toxicity of MPTP to dopamine neurons in culture is reduced at high concentrations
7. Bisabolone derivatives and sesquiterpene lactones from Centaurea species
8. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurones explains selective toxicity
9. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects
10. Flavonoid C-glycosides from the flowers of Centaurea solstitialis L. (Compositae)
11. Flavonoid C-glycosides from the flowers of Centaurea solstitialis L. (Compositae)
12. Novel plant-derived tumor inhibitors and their mechanisms of action
13. Novel plant-derived tumor inhibitors and their mechanisms of action
14. Amytrophic lateral sclerosis and Parkinson's disease complex on Guam linked to an environmental neurotoxin
15. MPTP: Current concepts and controversies
16. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
17. Sesquiterpene lactones from Centaurea solstitialis
18. Observations on the toxic effects of yellow star thistle
19. Toxic effects of environmental neuro toxins related to 1-methyl-4-phenylpyridinium on cultured rat dopaminergic neurons
20. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine destroys dopamine neurons in explants of rat embryo mesencephalon.
21. Studies on the metabolism and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in cultures of embryonic rat mesencephalon
22. Characterisation of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
23. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin
24. Repin, a sesquiterpene lactone from Acroptilon repens possessing exceptional biological activity
25. Separation and identification of labile polyacetylenes by RP-HPLC
26. Separation and identification of labile polyacetylenes by RP-HPLC
27. The role of environmental toxins in the etiology of Parkinson's disease
28. Neurotoxic sequiterpenoids from the yellow star thistle Centaurea solstitialis L. (Asteraceae)
29. Monoamine oxidase activity and distribution in marmoset brain: Implications for MPTP toxicity