GB (guanidinobenzoatase) cell surface protease and serum inhibitors in colorectal neoplasia

The Journal of Pathology

Volumn 167, Issue 1, 1992, Pages 19-24

  Steven, Frank S ^a   Griffin, Margaret M ^a   Talbot, Ian C ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ST MARK S HOSPITAL   (United Kingdom)

Author keywords

carcinoma cells; fluorescent analysis; guanidinobenzoatase; invasion; metastasis; Plasminogen activator

Indexed keywords

CELL SURFACE PROTEIN; GUANIDINOBENZOATASE; PLASMINOGEN ACTIVATOR; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INVASION; COLORECTAL TUMOR; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN TISSUE; METASTASIS; PRIORITY JOURNAL;

ADENOCARCINOMA; ADENOMA; AMINACRINE; CARBOXYLIC ESTER HYDROLASES; COLORECTAL NEOPLASMS; HUMAN; INTESTINAL MUCOSA; ISOENZYMES; MICROSCOPY, FLUORESCENCE; PROTEASE INHIBITORS; SUPPORT, NON-U.S. GOV'T; TUMOR MARKERS, BIOLOGICAL;

EID: 0026550510     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1711670105     Document Type: Article

References (13)

1. The spread of tumours
2. Proteolytic degradation of extra‐cellular matrix in tumour invasion
3. Membrane and matrix localisation of proteinases: a common theme in tumour cell invasion and angiogenesis
4. Plasminogen, the serum proenzyme, activated by factors from cells transformed by oncogenic viruses
5. Urokinase‐type and tissue‐type plasminogen activators are essential for in vitro invasion of human melanoma cells
6. Direct evidence for the cell surface location of a protease inhibitor complex on intact leukaemia cells
7. Evidence for an enzyme which cleaves the guanidinobenzoate moiety from active site titrants specifically designed to inhibit and quantify trypsin
8. The design of fluorescent probes which bind to the active centre of guanidinobenzoatase
9. Exchange of inhibitors reacting with a tumour cell protease
10. Evidence for distinct isoenzymatic forms of a cell surface protease on normal colonic cells and on carcinoma cells of the same colon
11. Inhibition of a protease associated with tumour cells and the probable mechanism of regulation of this interaction in vivo
12. Temporary competitive inhibition of a tumour cell surface protease as a protective mechanism in the preparation of the membrane bound native enzyme in the presence of excess cytoplasmic inhibitors