Evidence of a natural killer (NK) cell repertoire for (Allo) antigen recognition: Definition of five distinct NK-determined allospecificities in humans

Journal of Experimental Medicine

Volumn 175, Issue 3, 1992, Pages 709-718

  Ciccone, Ermanno ^a   Pende, Daniela ^a   Viale, Oriane ^a   Di Donate, Carolina ^a   Tripodi, Gino ^a   Orengo, Anna Maria ^b   Guardiola, John ^c   Moretta, Alessandro ^a,b   Moretta, Lorenzo ^a,d  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; PHYTOHEMAGGLUTININ;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; GENE SEGREGATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; REGULATOR GENE;

ALLELES; CHROMOSOMES, HUMAN, PAIR 6; CLONE CELLS; EPITOPES; FLOW CYTOMETRY; GENES, DOMINANT; GENES, RECESSIVE; HAPLOTYPES; HISTOCOMPATIBILITY TESTING; HUMAN; ISOANTIGENS; KILLER CELLS, NATURAL; LYMPHOCYTE CULTURE TEST, MIXED; MAJOR HISTOCOMPATIBILITY COMPLEX; PEDIGREE; SUPPORT, NON-U.S. GOV'T;

EID: 0026550049     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.175.3.709     Document Type: Article

References (18)

1. Herberman, R.B., and J.R. Ortaldo. 1981. Natural killer cells: the role in defence against disease. Science (Wish. DC). 214:24.
2. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
3. - lymphocytes in mixed lymphocyte culture. J. Exp. Med. 168:2403.
4. Suzuki, N., E. Bianchi, H. Bass, T. Suzuki, J. Bender, R. Pardi, C.A. Brenner, J.W. Larrick, and E.G. Engleman. 1990. Natural killer lines and clones with apparent antigen specificity. J. Exp. Med. 172:457.
5. Bender, J.R., R. Pardi, and E. Engleman. 1990. T-cell receptor negative natural killer cells display antigen-specific cytotoxicity for microvascular endothelial cells. Proc. Natl. Acad. Sci. USA. 87:694.
6. + natural killer cells requires the expression of an autosomic recessive gene on target cells. J. Exp. Med. 172:47.
7. Ciccone, E., M. Colonna, O. Viale, D. Pende, C. Di Donato et al. 1990. Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between Bf and HLA-B. Proc. Natl. Acad. Sci. USA. 87:9794; and correction 1991. 88:5477.
8. Moretta, A., G. Pantaleo, L. Moretta, J.C. Cerottini, and M.C. Mingari. 1983. Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity. J. Exp. Med. 157:743.
9. Bottino, C., G. Tambussi, S. Ferrini, E. Ciccone, M.C. Mingari, P. Varese, L. Moretta, and A. Moretta. 1988. Two subsets of human T lymphocytes expressing γ/δ antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor. J. Exp. Med. 168:491.
10. + human "natural killer" cells. Int. J. Cancer. 44:727.
11. + "natural killer" cells. Role in cell activation and regulation of cytolytic function. J. Exp. Med. 17:695.
12. + natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J. Exp. Med. 172:1589.
13. Atkin, M., D. Anderson, B. Francis, and J. Hinde. Statistical Modelling in GLM. Oxford Science Publications. Clarendon Press, Oxford University Press, Eynsham, Oxon. 107-112.
14. Baker, R., and J. Webster. The GLIM manual (release 3.77) NAG, Oxford, 1978. The Generalized Linear Interactive Modelling (GLIM) System. Numerical Algorithms Group. C.D. Payne, editor. Royal Statistical Society. London 1987.
15. Baker, R., and J. Webster. The GLIM manual (release 3.77) NAG, Oxford, 1978. The Generalized Linear Interactive Modelling (GLIM) System. Numerical Algorithms Group. C.D. Payne, editor. Royal Statistical Society. London 1987.
16. 1 hybrid mice. J. Exp. Med. 134:1513.
17. Bennet, M. 1987. Biology and genetics of hybrid resistance. Adv. Immunol. 41:333.
18. Ljunggren, H.G., and K. Karre. 1990. In search of the "missing self": MHC molecules and NK cell recognition. Immunol. Today. 11:237.