Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes

Journal of Investigative Dermatology

Volumn 98, Issue 4, 1992, Pages 421-427

  Pincelli, Carlo ^a   Fantini, Fabrizio ^a   Romualdi, Patrizia ^b   Sevignani, Cinzia ^a   Lesa, Giovanni ^b   Benassi, Luisa ^a   Giannetti, Alberto ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; CELL GROWTH; KERATINOCYTE; PRIORITY JOURNAL; PSORIASIS;

CELL DIVISION; CELLS, CULTURED; HUMAN; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; PSORIASIS; RADIOIMMUNOASSAY; SUBSTANCE P; SUPPORT, NON-U.S. GOV'T; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0026547899     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12499846     Document Type: Article

References (61)

1. E.M. Farber M.L. Nail The natural history of psoriasis in 5,000 patients Dermatologica 148 1974 1 18
2. E.M. Farber G. Rein S.W. Lanigan Stress and psoriasis. Psyconeuroimmunologic mechanisms Int J Dermatol 30 1991 8 12
3. E.M. Farber S.W. Lanigan J. Boer The role of cutaneous sensory nerves in the maintenance of psoriasis Int J Dermatol 29 1990 418 420
4. J.E. Bernstein L.C. Parish M. Rapaport M.M. Rosenbaum H.H. Roenigk Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris J Am Acad Dermatol 15 1986 504 507
5. S.H. Buck T.F. Burks Capsaicin: hot new pharmacological tool Trends Pharmacol Sci 4 1983 84 87
6. P. Holzer Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachychinins, calcitonin gene-related peptide and other neuropeptides Neuroscience 24 1988 739 768
7. E.M. Farber B.J. Nickoloff B. Recht J.E. Fraky Stress, symmetry, and psoriasis: possible role of neuropeptides J Am Acad Dermatol 14 1986 305 311
8. S.I. Said Vasoactive intestinal polypeptide (VIP): current status Peptides 5 1984 143 150
9. L.L. Iversen Substance P Br Med Bull 38 1982 277 282
10. W. Hartschuh M. Reinecke E. Weihe N. Yanaihara VIP-immunoreactivity in the skin of various mammals: immunohistochemical, radioimmunological and experimental evidence for a dual localization in cutaneous nerves and Merkel cells Peptides 5 1984 239 245
11. C.J. Dalsgaard C.E. Jonsson T. Hokfelt A.C. Cuello Localization of substance P-immunoreactive nerve fibers in the human digital skin Experientia 39 1983 1018 1020
12. W. Hartschuh E. Weihe M. Reineke Peptidergic (neurotensin, VIP, substance P) nerve fibers in the skin. Immunohistochemical evidence of an involvement of neuropeptides in nociception, pruritus, and inflammation Br J Dermatol 109 1983 14 17
13. J. Wallengren R. Hakanson Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responses Eur J Pharmacol 143 1987 267 273
14. W. Piotrowsky J.C. Foreman On the actions of substance P, somatostatin, and vasoactive intestinal polypeptide on rat peritoneal mast cells and in human skin Naunyn Schmiedebergs Arch Pharmacol 331 1985 364 368
15. M.S. O'Dorisio Neuropeptide modulation of the immune response in gut associated lymphoid tissue Int J Neurosci 38 1988 189 198
16. C.J. Dalsgaard A. Hultgardh-Nilsson A. Haegerstrand J. Nilsson Neuropeptides as growth factors. Possible roles in human diseases Regul Pept 25 1989 1 9
17. A. Haegerstrand B. Jonzon C.J. Dalsgaard J. Nilsson Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes Proc Natl Acad Sci USA 86 1989 5993 5996
18. H. Pinkus A.H. Mehregan The primary histologic lesion in seborrheic dermatitis and psoriasis J Invest Dermatol 46 1966 109 116
19. C. Schubert E. Christophers Mast cells and macrophages in early relapsing psoriasis Arch Dermatol Res 277 1985 352 358
20. G.D. Weinstein J.I. McCullough P.A. Ross Cell kinetic basis for pathophysiology of psoriasis J Invest Dermatol 85 1985 579 583
21. V.E. Ghazarossian C. Chavkin A. Goldstein A specific radioimmunoassay for the novel opioid peptide dynorphin Life Sci 27 1980 75 86
22. P. Romualdi J.G. Rosenberger L. Gozzini B.M. Cox Vasoactive intestinal polypeptide carboxy-terminal fragment, VIP (22-28), and other fragments of VIP, in the central nervous system of the rat Peptides 10 1989 621 626
23. P. Romualdi G. Lesa B.M. Cox S. Ferri Distribution and characterization of VIP-related peptides in rat spinal cord Neuropeptides 16 1990 219 225
24. H. Green Terminal differentiation of cultured human epidermal cells Cell 11 1977 405 416
25. F. Fantini C. Pincelli P. Massimi A. Giannetti Neuropeptide-like immunoreactivity in skin lesions of atopic dermatitis and psoriasis Br J Dermatol 122 1990 838 839
26. O. Johansson A. Olsson A. Enhamre H. Hammar M. Goldstein Phenylethanolamine N-methyl-transferase-like immunoreactivity in psoriasis. An immunohistochemical study on catecholamine synthesizing enzymes and neuropeptides of the skin Acta Derm Venereol (Stockh) 67 1987 1 7
27. A. Naukkarinen B.J. Nickoloff E.M. Farber Quantification of cutaneous sensory nerves and their substance P content in psoriasis J Invest Dermatol 92 1989 126 129
28. O. Johansson S.W. Han A. Enhamre Alteration of cutaneous nerves in psoriasis revealed by an antiserum to protein gene product (PGP) 9.5 (abstr) 21st Annual E.S.D.R. Meeting 1991 Copenhagen 32 June 1-3
29. O. Johansson A detailed account of NPY-immunoreactive nerves and cells of the human skin. Comparison with VIP-, substance P- and PHI-containing structures Acta Physiol Scand 128 1986 147 153
30. J. Wallengren R. Ekman F. Sundler Occurrence and distribution of neuropeptides in the human skin Acta Derm Venereol (Stockh) 67 1987 185 192
31. H. Björklund C.J. Dalsgaard C.E. Jonsson A. Hermansson Sensory and autonomic innervation of non-hairy and hairy human skin. An immunohistochemical study Cell Tissue Res 243 1986 51 57
32. J. Wallengren R. Ekman H. Moller Substance P and vasoactive intestinal peptide in bullous and inflammatory skin disease Acta Derm Venereol (Stockh) 66 1986 23 28
33. D.J. Eedy C.F. Johnston C. Shaw K.D. Buchanan Neuropeptides in psoriasis: an immunocytochemical and radioimmunoassay study J Invest Dermatol 96 1991 434 438
34. P. Anand D.R. Springall M.A. Blank D. Sellu J.M. Polak S.R. Bloom Neuropeptides in skin diseases: increased VIP in eczema and psoriasis but not axillary hyperhidrosis Br J Dermatol 124 1991 547 549
35. L. Ek E. Theodorsson Tachychinins and calcitonin gene-related peptide in oxazolone-induced allergic contact dermatitis in mice J Invest Dermatol 94 1990 761 763
36. F. Fantini C. Pincelli P. Romualdi G. Lesa A. Giannetti Quantification of substance P cutaneous levels in atopic dermatitis (abstr) 21st Annual E.S.D.R. Meeting 1991 Copenhagen 54 June 1-3
37. C. Pincelli F. Fantini P. Romualdi G. Lesa A. Giannetti Skin levels of vasoactive intestinal polypeptide in atopic dermatitis Arch Dermatol Res 283 1991 230 232
38. M.J. Villar R. Cortes E. Theodorsson Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin Neuroscience 33 1989 587 604
39. U. Nielsch P. Keen Reciprocal regulation of tachykinin — and vasoactive intestinal peptide — gene expression in rat sensory neurones following cut and crush injury Brain Res 481 1989 25 30
40. W. Hartschuh E. Weihe Fine structural analysis of the synaptic junction of Merkel cell-axon complexes J Invest Dermatol 75 1980 159 165
41. E. Cutz W. Chan N. Track A. Goth S. Said Release of vasoactive intestinal polypeptide in mast cells by histamine liberators Nature 275 1978 661 663
42. S. Töyry J. Fraky R. Tammi Mast cell density in psoriatic skin. The effect of PUVA and corticosteroid therapy Arch Dermatol Res 280 1988 282 285
43. E.J. Goetzl T. Chernov-Rogan K. Furuichi L.M. Goetzl J.Y. Lee F. Renold Neuromodulation of mast cell and basophil function A.D. Befus J. Bienenstock J.A. Denburg Mast Cell Differentiation and Heterogeneity 1985 Raven Press New York
44. M.S. O'Dorisio T.M. O'Dorisio S. Cataland S.P. Balcerzak Vasoactive intestinal polypeptide as a biochemical marker for polymorphonuclear leukocytes J Lab Clin Med 96 1980 666 670
45. J. Aliakbari S.P. Sreedharan C.W. Turck E.J. Goetzl Selective localization of vasoactive intestinal peptide and substance P in human eosinophils Biochem Biophys Res Commun 148 1987 1440 1445
46. J. Brown P. Perry S.H. Hefeneider J.C. Ansel Neuropeptide modulation of keratinocyte cytokine production Molecular and Cellular Biology of Cytokines 1990 Wiley-Liss, Inc. New York 451 456
47. M. Rabier D.I. Wilkinson E.M. Farber Neuropeptides modulate leukotriene B4 mitogenicity towards cultured keratinocytes (abstr) J Invest Dermatol 96 1991 628
48. M.J. Berridge R.M.C. Dawson C.P. Downes J.P. Heslop R.F. Irvin Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides Biochem J 212 1983 473 483
49. A. Hultgård-Nilsson J. Nilsson B. Jonzon C.J. Dalsgaard Growth inhibitory properties of vasoactive intestinal polypeptide Regul Pept 20 1988 267 274
50. M.J. Berridge R.F. Irvine Inositol triphosphate, a novel second messenger in cellular signal transduction Nature 312 1984 315 321
51. D.J. Kelleher J.E. Pessin A.E. Ruoho G.L. Johnson Phorbol ester induces desensitization of adenylate cyclase and phosphorilation of the β-adrenergic receptor in turkey erythrocytes Proc Natl Acad Sci USA 81 1984 4316 4320
52. M.R. Hanley Neuropeptides as mitogens Nature 315 1985 14 15
53. D.G. Payan D.R. Brewster E.J. Goetzl Specific stimulation of human T lymphocytes by substance P J Immunol 131 1983 1613 1615
54. M. Lotz J.H. Vaughan D.A. Carson Effect of neuropeptides on production of inflammatory cytokines by human monocytes Science 241 1989 1218 1221
55. A.M. Stanisz D. Befus J. Bienenstock Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer's patches, mesenteric lymph nodes, and spleen J Immunol 136 1986 152 156
56. C.A. Ottaway Selective effects of vasoactive intestinal peptide on the mitogenic response of murine T cells Immunology 62 1987 291 297
57. T.C. Moore Modification of lymphocyte traffic by vasoactive neuro-transmitter substances Immunology 52 1984 511 518
58. M. Rola-Pleszczynski D. Bulduc A. St Pierre The effects of VIP on human NK cell function J Immunol 135 1985 2659 2673
59. Girolomoni G. Tigelaar R.E: Peptidergic neurons and vasoactive intestinal peptide modulate experimental delayed-type hypersensitivity reactions. Ann NY Acad Sci (in press)
60. S.I. Said Neuropeptides as modulators of injury and inflammation Life Sci 47 1990 19 21
61. M.E. Trotz J. Luis S.I. Said Vasoactive intestinal peptide (VIP) inhibits phospholipase A2: a mechanism of anti-inflammatory activity (abstr) Faseb J 4 1990 1124