Renewed DNA synthesis in senescent WI‐38 cells by expression of an inducible chimeric c‐fos construct

Journal of Cellular Physiology

Volumn 151, Issue 1, 1992, Pages 206-212

  Phillips, Paul D ^a   Pignolo, Robert J ^a   Nishikura, Kazuko ^b   Cristofalo, Vincent J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MURINAE; OVIS ARIES;

ARTICLE; CELL AGING; DNA SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C FOS; PRIORITY JOURNAL;

AGING; BLOTTING, NORTHERN; BROMODEOXYURIDINE; CELL DEATH; CELL DIVISION; CELLS, CULTURED; CHIMERA; DNA; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMAN; IMMUNOENZYME TECHNIQUES; METALLOTHIONEIN; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.; THYMIDINE; TRANSFECTION; ZINC;

EID: 0026544969     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.1041510126     Document Type: Article

References (36)

1. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
2. 1 and S
3. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
4. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
5. Vectors for expression and amplification of cDNA in mammalian cells: Expression of rat phenylalanine hydroxylase
6. Cellular senescence: Factors modulating cell proliferation in vitro
7. A standard procedure for cultivating human diploid fibroblast‐like cells to study cellular aging
8. Cellular senescence and DNA synthesis
9. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: Direct participation of c‐fos
10. High efficiency DNA‐mediated transformation of human diploid fibroblasts
11. The fos complex and fos‐related antigens recognize sequence elements that contain AP‐1 binding sites
12. Ribonucleic acid isolated by cesium chloride centrifugation
13. Reinitiation of cellular DNA synthesis in BrdU‐selected nondividing senescent WI‐38 cells by simian virus 40 infection
14. Characterization of cell cycle of cultured human diploid cells: Effects of aging and hydrocortisone
15. The limited in vitro lifetime of human diploid cell strains
16. Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR‐MuSV
17. Expression of a set of growth‐related immediate early genes in BALB/c3T3 cells: Coordinate regulation with c‐fos or c‐myc
18. Avian sarcoma virus 17 carries the jun oncogene
19. Towards an understanding of the malignant transformation of diploid human fibroblasts
20. Removal of a 67‐base‐pair sequence in the noncoding region of the protooncogene fos converts it to a transforming gene
21. c‐fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene
22. Characteristics of an infinite life span diploid human fibroblast cell strain and a near‐diploid strain arising from a clone of cells expression a transfected v‐myc oncogene
23. Thymidine triphosphate synthesis in senescent WI‐38 cells
24. Genetic analysis of indefinite division in human cells: Identification of four complementation groups
25. Hydrocortisone stimulation of DNA synthesis in Bromodeoxyuridine‐selected non‐dividing cells
26. Expression of cell cycle‐dependent genes in young and senescent WI‐38 fibroblasts
27. Analysis of the differentiation‐promoting potential of inducible c‐fos genes introduced into embryonal carcinoma cells
28. Induction of protooncogene c‐jun by serum growth factors
29. Repression of c‐fos transcription and an altered genetic program in senescent human fibroblasts
30. Transcriptional activation encoded by the v‐fos gene
31. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T‐antigen
32. A conserved AU sequence from the 3′ untranslated region of GM‐CSF mRNA mediates selective mRNA degradation
33. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
34. 2‐microglobin
35. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts