The Protective Role of Glutathione, Cysteine and Vitamin C against Oxidative DNA Damage Induced in Rat Kidney by Potassium Bromate

Japanese Journal of Cancer Research

Volumn 83, Issue 1, 1992, Pages 45-51

  Sai, Kimie ^a   Umemura, Takashi ^a   Takagi, Atsuya ^a   Hasegawa, Ryuichi ^a   Kurokawa, Yuji ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

8 Hydroxy deoxyguanosine; Cysteine; Glutathione; Lipid peroxidation; Potassium bromate

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA TOCOPHEROL; ASCORBIC ACID; CYSTEINE; FOOD ADDITIVE; GLUTATHIONE; GUANOSINE DERIVATIVE; MALEIC ACID DIETHYL ESTER; POTASSIUM BROMATE; SUPEROXIDE DISMUTASE; THIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; KIDNEY; KIDNEY MASS; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ASCORBIC ACID; BROMATES; CYSTEINE; DEOXYGUANOSINE; DNA DAMAGE; GLUTATHIONE; KIDNEY; LIPID PEROXIDATION; MALE; MALEATES; ORGAN WEIGHT; OXIDATION-REDUCTION; RATS; RATS, INBRED F344; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; SUPPORT, NON-U.S. GOV'T; VITAMIN E;

EID: 0026544394     PISSN: 09105050     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1992.tb02350.x     Document Type: Article

References (38)

1. Carcinogenicity of potassium bromate administered orally to F344 rats
2. IARC monographs on evaluation of the carcinogenic risk of chemicals to humans
3. Toxicity and carcinogenicity of potassium bromate, a new renal carcinogen
4. Dose‐related enhancing effect of potassium bromate on renal tumorigenesis in rats initiated with N‐ethyl‐N‐hydroxyethylnitrosamine
5. Comparative studies on lipid peroxidation in the kidney of rats, mice, and hamsters and on the effect of cysteine, glutathione, and diethylmaleate treatment on mortality and nephrotoxicity after administration of potassium promate
6. Formation of 8‐hy‐droxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
7. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8‐hydroxydeoxyguanosine in rat target organ DNA
8. Formation of 8‐hydroxydeoxyguanosine (8‐OH‐dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe‐NTA)
9. Significant increase of 8‐hydroxydeoxyguanosine in liver DNA of rats following short‐term exposure to the peroxisome proliferators di(2‐ethylhexyl)phthalate and di(2‐ethylhexyl)adipate
10. Formation of 8‐hydroxydeoxyguanosine in liver DNA of rats following long‐term exposure to a peroxisome proliferator
11. Oxidative DNA and RNA damage in the livers of Sprague‐Dawley rats treated with the hepatocarcinogen 2‐nitropropane
12. Oxidative DNA and RNA damage in rat liver due to acetoxime: similarity to effects of 2‐nitropropane
13. The effect of exogenous glutathione and cysteine on oxidative stress induced by ferric nitrilotriacetate
14. Relation of 8‐hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate
15. The role of 8‐hydroxyguanine in carcinogenesis
16. The effect of depletion on non protein sulfhydryls by diethylmaleate plus buthionine sulfoximine on renal uptake of mercury in the rat
17. Enhancement by glutathione depletion of ethanol‐induced acute hepatotoxicity in vitro and in vivo
18. The implication of renal glutathione levels in mercuric chloride nephrotoxicity
19. Effect of buthionine sulfoximine on acute N‐(3, 5‐dichloro‐phenyl)succinimide‐induced nephrotoxicity in Fischer 344 rats
20. Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation
21. Rat kidney function related to tissue glutathione levels
22. Detection of malonaldehyde precursor in tissue by thiobarbituric acid test
23. Tissue sulfhydryl groups
24. Treatment of carbon tetrachloride‐induced liver necrosis with chemical compounds
25. Therapeutic effectiveness of cysteine to reduce liver cell necrosis induced by several hepatotoxins
26. Protective effect of antioxidants against endrin‐induced lipid peroxidation, glutathione depletion, and lethality in rats
27. Liposome‐encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen
28. Effect of vitamin E on carbon tetrachloride‐induced lipid peroxidation as demonstrated by in vivo pentane production
29. Metabolism of potassium bromate in rats II. In vitro studies
30. Glutathione: interorgan translocation, turnover, and metabolism
31. Mechanism of renal peritubular extraction of plasma glutathione
32. Transport of glutathione by renal basal‐lateral membrane vesicles
33. The intracellular ratio of cysteine and cystine in various tissues
34. Utilization of L‐cystine by γ‐glutamyl transpeptidase‐γ‐glutamyl cyclotransferase pathway
35. Misreading of DNA template containing 8‐OH‐dG at the modified base at adjacent residues
36. Mechanistic studies of ionizing irradiation and oxidative mutagenesis: genetic effects of single 8‐hydroxyguanine (8‐oxoguanine) residue inserted at a unique site in a viral genome
37. Insertion of specific bases during DNA synthesis past the oxidation‐damaged base 8‐oxo‐dG