Nicotine Enhances 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Neurotoxicity

Journal of Neurochemistry

Volumn 58, Issue 2, 1992, Pages 776-779

  Behmand, Ramin A ^a   Harik, Sami I ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine neurotoxicity; Cigarette smoking; Nicotine; Nigrostriatal degeneration; Nigrostriatal dopaminergic system; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; MALE; MOUSE; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SMOKING;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMAL; BEHAVIOR, ANIMAL; CORPUS STRIATUM; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; MALE; MICE; MICE, INBRED STRAINS; NERVOUS SYSTEM; NEUROTOXINS; NICOTINE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026543361     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1992.tb09786.x     Document Type: Article

References (28)

1. Cigarette smoking and Parkinson's disease
2. Attenuation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced neurotoxicity by cigarette smoke
3. Quantitative analysis of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine metabolism in isolated rat hepatocytes
4. Effect of nicotine pretreatment on striatal dopaminergic system in rats
5. Chronic administration of nicotine fails to alter the MPTP‐induced neurotoxicity in mice
6. Regulation of dopamine release by presynaptic nicotinic receptors in rat striatal slices: effects of nicotine in low concentration
7. Validation of self‐reported smoking behavior: biochemical analyses of cotinine and thiocyanate
8. Monoamine neurotransmitters in diffuse reversible forebrain ischemia and early recirculation: increased dopaminergic activity
9. Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
10. Chronic nicotine treatment partly protects against the 1‐methyl‐Cphenyl‐1,2,3,6‐tetrahydropyridine‐induced degeneration of nigrostriatal dopamine neurons in the black mouse
11. MPTP toxicity: implications for research in Parkinson's disease
12. The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism
13. Microsomal nicotine metabolism: a comparison of relative activities of six purified rabbit cytochrome P‐450 isozymes
14. Platelet monoamine oxidase: low activity in cigarette smokers
15. Studies on the cytochrome P‐450 catalyzed ring a‐carbon oxidation of the nigrostriatal toxin 1‐methyl‐Cphenyl‐1,2,3,6‐tetrahydropyridine (MPTP)
16. Exposure to cigarette smoke does not decrease neurotoxicity of N‐methyl‐Cphenyl‐1,2,3,6‐tetrahydropyndine in mice
17. Strain differences in systemic 1‐methyl‐4‐phenyl‐l,2,3,6‐tetrahydropyndine neurotoxicity in mice correlate best with monoamine oxidase activity at the blood‐brain barrier
18. On the mechanisms underlying 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahy‐dropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver
19. Behavioral and biochemical effects of nicotine in an MPTP‐induced mouse model of Parkinson's disease
20. Effect of chronic oral nicotine on dopaminergic function in the MPTP‐treated mouse
21. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced neurotoxicity: partial protection against striato‐nigral dopamine depletion in C57BL/6J mice by cigarette smoke exposure and by β‐naphthoflavone‐pretreatment
22. MPTP a neurotoxin relevant to the pathophysiology of Parkinson's disease
23. The influence of dose and dosing interval on the dopaminergic neurotoxicity in mice
24. Cotinine in the serum, saliva and urine of nonsmokers, passive smokers, and active smokers
25. 3H‐dopamine from rat brain slices
26. Dopamine D1 receptor and dopamine D2 receptor binding activity changes during chronic administration of nicotine in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐treated mice
27. The role of cytochromes P‐450 and flavin‐containing monooxygenase in the metabolism of (S)‐nicotine by rabbit lung
28. Irreversible inhibition of monoamine oxidase by some components of cigarette smoke