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Volumn 10, Issue 14, 1992, Pages 1039-1052

Development of a vaccine for the prevention of AIDS, a critical appraisal

Author keywords

AIDS; animal models; clinical trials; ethical legal issues; HIV; pathogenesis; vaccine development

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS VACCINE;

EID: 0026539681     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(92)90114-Y     Document Type: Article
Times cited : (22)

References (108)
  • 1
    • 84915922508 scopus 로고
    • Pathogenesis and pathology of viral infections
    • 3rd edn, Academic Press, Orlando, FL
    • (1986) Medical Virology , pp. 134-143
    • White1    Fenner2
  • 2
    • 0025058788 scopus 로고
    • The immunological principles of vaccination
    • (1990) Lancet , vol.335 , pp. 523-526
    • Ada1
  • 3
    • 0026551082 scopus 로고
    • Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants
    • (1992) Science , vol.255 , pp. 1134-1137
    • Wolinsky1
  • 4
    • 0021999466 scopus 로고
    • Acute AIDS retrovirus infection; definition of a clinical illness associated with seroconversion
    • (1985) Lancet , vol.1 , pp. 537-540
    • Cooper1    Gold2    Maclean3
  • 5
    • 0023202977 scopus 로고
    • Isolation of human immunodeficiency virus (HIV) from plasma during primary HIV infection
    • (1987) J. Med. Virol. , vol.23 , pp. 67-73
    • Albert1
  • 6
    • 0025761245 scopus 로고
    • High titres of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection
    • (1991) N. Engl. J. Med. , vol.324 , pp. 954-960
    • Clark1
  • 7
    • 0025735965 scopus 로고
    • Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection
    • (1991) N. Engl. J. Med. , vol.324 , pp. 961-964
    • Daar1
  • 9
    • 0026557112 scopus 로고
    • Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody
    • (1992) Nature , vol.355 , pp. 728-730
    • Emini1    Schleif2    Nunberg3
  • 11
    • 0021833513 scopus 로고
    • Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients
    • (1985) Science , vol.228 , pp. 593-595
    • Robey1    Safai2    Oroszlan3
  • 12
    • 0022352075 scopus 로고
    • Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene
    • (1985) Science , vol.229 , pp. 1402-1405
    • Veronese1    DeVico2    Copeland3
  • 14
    • 0021751840 scopus 로고
    • The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
    • (1984) Nature , vol.312 , pp. 763-767
    • Dalgleish1    Beverley2    Clapham3
  • 16
    • 0022587282 scopus 로고
    • Binding of HTLV-III/LAV to T4 + T cells by a complex of the 110K viral protein and the T4 molecule
    • (1986) Science , vol.231 , pp. 382-385
    • McDougal1    Kennedy2    Sligh3
  • 17
    • 0022966842 scopus 로고
    • Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein
    • (1986) Nature , vol.323 , pp. 725-728
    • Lifson1    Feinberg2    Reyes3
  • 18
    • 0023217711 scopus 로고
    • Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1
    • (1987) Science , vol.237 , pp. 1351-1355
    • Kowalski1    Potz2    Basiripour3
  • 19
    • 0023644926 scopus 로고
    • pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
    • (1987) Cell , vol.49 , pp. 659-668
    • Stein1    Gowda2    Lifson3
  • 21
    • 0026361459 scopus 로고
    • The role of the V3 loop of gp120 in HIV infection
    • (1991) AIDS , vol.5 , pp. S21-S23
    • Moore1    Nara2
  • 22
    • 0025783669 scopus 로고
    • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1
    • (1991) Science , vol.253 , pp. 71-74
    • Hwang1    Boyle2    Lyerly3
  • 23
    • 0025696633 scopus 로고
    • Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1
    • (1990) Science , vol.250 , pp. 1590-1593
    • Javaherian1    Langlois2    LaRosa3
  • 24
    • 0025958022 scopus 로고
    • Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody
    • (1991) J. Virol. , vol.65 , pp. 489-493
    • Ho1    McKeating2    Li3
  • 25
    • 0026085170 scopus 로고
    • Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody
    • (1991) J. Virol. , vol.65 , pp. 6188-6193
    • Thali1    Olshevsky2    Furman3
  • 27
    • 0026044947 scopus 로고
    • Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120
    • (1991) Science , vol.254 , pp. 105-108
    • Steimer1    Scandella2    Skiles3
  • 28
    • 0025775863 scopus 로고
    • Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humans
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6171-6175
    • Kang1    Nara2    Chamat3
  • 31
    • 0025362335 scopus 로고
    • Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees
    • (1990) J. Virol. , vol.64 , pp. 3779-3791
    • Nara1    Smit2    Dunlop3
  • 32
    • 0024390828 scopus 로고
    • The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells
    • (1989) Science , vol.244 , pp. 1357-1360
    • Homsy1    Meyer2    Tateno3
  • 33
    • 0025135485 scopus 로고
    • HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor
    • (1990) Nature , vol.343 , pp. 659-661
    • McKeating1    Griffiths2    Weiss3
  • 35
    • 0026362678 scopus 로고
    • HIV epitopes recognized by cytotoxic T-lymphocytes
    • (1991) AIDS , vol.5 , pp. S145-S150
    • Autran1    Letvin2
  • 36
    • 0025827529 scopus 로고
    • Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
    • (1991) Nature , vol.354 , pp. 453-459
    • Phillips1    Rowland-Jones2    Nixon3
  • 37
    • 0024458517 scopus 로고
    • A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160
    • (1989) Science , vol.246 , pp. 118-124
    • Takahashi1    Merli2    Putney3
  • 40
    • 84915910824 scopus 로고    scopus 로고
    • McGhee, J.R. and Mestecky, J. The mucosal immune system in HIV infection and prospects for mucosal immunity to AIDS. Annu. Rev. AIDS Res. In press.
  • 41
    • 0025271057 scopus 로고
    • Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals
    • (1990) J. Virol. , vol.64 , pp. 2290-2297
    • Sutjipto1    Pedersen2    Miller3
  • 42
    • 0344108275 scopus 로고
    • SIV vaccines, 1991 a year in review
    • (1991) AIDS , vol.5 , pp. S115-S127
    • Gardner1    Hu2
  • 43
    • 0026519706 scopus 로고
    • Protection of macaques against SIV infection by subunit vaccine of SIV envelope glycoprotein gp160
    • (1992) Science , vol.255 , pp. 456-459
    • Hu1    Abrams2    Barber3
  • 44
    • 84915910823 scopus 로고    scopus 로고
    • Cooney, E.L., Corey, L., Hu, S.L. et al. Enhanced immunity to HIV envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein. Science Submitted for publication
  • 48
    • 0025897051 scopus 로고
    • Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines
    • (1991) Nature , vol.351 , pp. 479-482
    • Aldovini1    Young2
  • 49
    • 0026361431 scopus 로고
    • HIV-1 neutralization directed to epitopes other than linear V3 determinants
    • (1991) AIDS , vol.5 , pp. S135-S143
    • Steimer1    Klasse2    McKeating3
  • 50
    • 0023941817 scopus 로고
    • Identification of homologous regions in human immunodeficiency virus gp41 and human MHC class II beta I domain
    • (1988) J. Exp. Med. , vol.167 , pp. 914-923
    • Golding1    Robey2    Gates3
  • 52
    • 0026362977 scopus 로고
    • New AIDS vaccine candidates: antigen delivery and design
    • (1991) AIDS , vol.5 , pp. S151-S158
    • Aldovini1    Young2    Palker3
  • 53
    • 0026047610 scopus 로고
    • Long-term high-titre neutralizing activity induced by octameric synthetic HIV-1 antigen
    • (1991) Science , vol.254 , pp. 285-288
    • Wang1    Looney2    Li3
  • 56
    • 0024389666 scopus 로고
    • In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine
    • (1989) Nature , vol.342 , pp. 561-564
    • Deres1    Schild2    Wiesmuller3
  • 57
    • 0023643251 scopus 로고
    • The expression of hybrid HIV:Ty virus-like particles in yeast
    • (1987) Nature , vol.329 , pp. 68-70
    • Adams1    Dawson2    Gull3
  • 59
    • 0025310910 scopus 로고
    • Induction of cytotoxic T cells by immunization with complexes of purified HIV-1 envelope protein
    • (1990) Nature , vol.344 , pp. 873-875
    • Takahashi1    Takeshita2    Morein3
  • 60
    • 0025809334 scopus 로고
    • Universal vaccine carrier: liposomes that provide T dependent help to weak antigens
    • (1991) J. Immunol. , vol.146 , pp. 3697-3702
    • Garcon1    Six2
  • 63
    • 84915894360 scopus 로고
    • Expression of Il-1 by vaccinia virus: enhanced immune responses to vaccinia and co-expressed antigens
    • (1991) Cytokine , vol.3 , pp. 1
    • Ruby1    Ramshaw2
  • 66
    • 0003227221 scopus 로고
    • Planning for HIV vaccine trials: the World Health Organization perspective
    • (1995) AIDS , vol.5 , pp. S159-S163
    • Esparza1    Osmanov2    Kallings3
  • 67
    • 0014662591 scopus 로고
    • The use of primates in experimental viral infections—rubella and the rubella syndrome
    • (1969) Ann. NY Acad. Sci. , vol.162 , pp. 594-597
    • Horstmann1
  • 68
    • 0001416965 scopus 로고
    • Live attenuated poliovaccines
    • S.A. Plotkin, E.A. Mortimer, W.B. Saunders, Philadelphia
    • (1988) Vaccines , pp. 115-157
    • Melnick1
  • 69
    • 13344264027 scopus 로고
    • Mumps vaccine
    • S.A. Plotkin, E.A. Mortimer, W.B. Saunders, Philadelphia
    • (1988) Vaccines , pp. 223-234
    • Weibel1
  • 71
    • 0025616015 scopus 로고
    • Feline immunodeficiency virus as a model for AIDS vaccination
    • (1990) AIDS , vol.4 , pp. S163-S165
    • Jarrett1    Yamamoto2    Neil3
  • 73
    • 0023753744 scopus 로고
    • The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function
    • (1988) Science , vol.241 , pp. 1632-1639
    • NcCune1    Namikawa2    Kaneshima3
  • 74
    • 0023734130 scopus 로고
    • Transfer of a functional human immune system to mice with severe combined immunodeficiency
    • (1988) Nature , vol.335 , pp. 256-259
    • Mosier1    Gulizia2    Baird3
  • 75
    • 0025331727 scopus 로고
    • Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
    • (1990) Nature , vol.345 , pp. 622-625
    • Berman1    Gregory2    Riddle3
  • 76
    • 0025902165 scopus 로고
    • Anti-cell antibody in macaques
    • (1991) Nature , vol.353 , pp. 393
    • Stott1
  • 77
    • 0026019644 scopus 로고
    • The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) recombinant gp160 candidate vaccine in humans
    • (1991) Ann. Intern. Med. , vol.114 , pp. 119-127
    • Dolin1    Graham2    Greenberg3
  • 80
    • 0026555178 scopus 로고
    • Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons
    • (1992) J. Virol. , vol.661 , pp. 172-182
    • Haigwood1    Nara2    Brooks3
  • 81
    • 0025331727 scopus 로고
    • Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
    • (1990) Nature , vol.345 , pp. 622-625
    • Berman1    Gregoryo2    Riddle3
  • 82
    • 0025963146 scopus 로고
    • Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein
    • (1991) Lancet , vol.337 , pp. 567-572
    • Cooney1    Collier2    Greenberg3
  • 84
    • 0024599629 scopus 로고
    • Human immunodeficiency virus type-1 neutralizing monoclonal antibodies which react with p17 core protein: characterization and epitope mapping
    • (1989) J. Virol. , vol.63 , pp. 267-272
    • Papsidero1    Sheu2    Ruscetti3
  • 85
    • 0025356429 scopus 로고
    • HIV p24-specific helper T cell clones from immunized primates recognize highly conserved regions of HIV-1
    • (1990) J. Immunol. , vol.1 , pp. 1677-1683
    • Mills1    Kitchin2    Mahon3
  • 86
    • 0024802773 scopus 로고
    • A novel method for the purification of HIV-1 p24 protein from hybrid Ty virus-like particles (Ty-VLPs)
    • (1989) AIDS , vol.3 , pp. 717-723
    • Gilmour1    Senior2    Burns3
  • 87
    • 0026734288 scopus 로고
    • Vaccination of vaccinia-naive adults with HIV-1 gp160 recombinant vaccinia (HIVAC-1e) in a blinded controlled, randomized clinical trial
    • (1992) J. Infect. Dis. , vol.166 , pp. 244-252
    • Graham1    Belshe2    Clements3
  • 89
    • 0023912632 scopus 로고
    • A group specific anamnestic immune reaction against HIV-1 induced by a candidate vaccine against AIDS
    • (1988) Nature , vol.332 , pp. 728-731
    • Zagury1    Bernard2    Cheynier3
  • 91
    • 0023803544 scopus 로고
    • Antibody enhanced infection by HIV-1 via Fc receptor mediated entry
    • (1988) Science , vol.242 , pp. 580-583
    • Takeda1    Tuazon2    Ennis3
  • 92
    • 0024790804 scopus 로고
    • Human trials of AIDS vaccines: current status and future directions
    • (suppl)
    • (1989) AIDS , vol.3 , pp. S125-S129
    • Koff1    Fauci2
  • 93
    • 0345016834 scopus 로고
    • Interaction between the human T cell lymphotropic virus type IIIb envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5424-5428
    • Matthews1    Weinhold2    Lyerly3
  • 95
    • 0011184082 scopus 로고
    • Sequence variability in human immunodeficiency viruses: pattern and process in viral evolution
    • (1991) AIDS , vol.5 , pp. S35-S42
    • Leigh Brown1
  • 97
    • 84915910821 scopus 로고    scopus 로고
    • Ahearne, P.M., Sebastian, M.W., Morgan, R.A. et al. Identification of CTL reactivity against HIV-1 infected autologous B-cell lymphocyte cell lines. In preparation
  • 98
    • 0023731245 scopus 로고
    • Development and testing of AIDS vaccines
    • (1988) Science , vol.241 , pp. 426-432
    • Koff1    Hoth2
  • 100
    • 84915910820 scopus 로고
    • Advances in AIDS vaccine development: a global applied research strategy could expedite the development and testing of vaccine candidates
    • (1991) ASM News , vol.57 , pp. 73
    • Koff1
  • 106
    • 84915910818 scopus 로고    scopus 로고
    • World Medical Association Declaration of Helsinki. World Medical Association Inc. (amended Sept. 1989)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.