Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

Neuropharmacology

Volumn 31, Issue 4, 1992, Pages 343-347

  Caccia, S ^a   Fracasso, C ^a   Garattini, S ^a   Guiso, G ^a   Sarati, S ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

brain monoamines; fluoxetine; rat; repeated administration

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; BRAIN MONOAMINE; DIHYDROXYPHENYLACETIC ACID; DOPAMINE; DRUG METABOLITE; FLUOXETINE; HOMOVANILLIC ACID; NORADRENALIN; NORFLUOXETINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DOSE TIME EFFECT RELATION; DRUG BRAIN LEVEL; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; CEREBRAL CORTEX; COMPARATIVE STUDY; CORPUS STRIATUM; DOPAMINE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOXETINE; HIPPOCAMPUS; HOMOVANILLIC ACID; HYDROXYINDOLEACETIC ACID; INJECTIONS, INTRAPERITONEAL; RATS; RATS, INBRED STRAINS; REFERENCE VALUES; SEROTONIN; SUPPORT, NON-U.S. GOV'T;

EID: 0026536243     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(92)90066-X     Document Type: Article

References (22)

1. Application of the dual-cell coulometric detector: A method for assaying monoamines and their metabolites
2. Clinical pharmacology and pharmacokinetics of fluoxetine: A review
3. Anorectic activity of fluoxetine and norfluoxetine in rats: Relationship between brain concentrations and in vitro potencies on monoaminergic mechanisms
4. Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
5. Dopaminergic and serotoninergic anorectics differentially antagonize insulin- and 2-DG-induced hyperphagia
6. Fluoxetine-induced weight loss in overweight non-depressed humans
7. Drug treatment for bulimia and bulimia nervosa
8. Mechanisms of effects of d-fenfluramine on brain serotonin metabolism in rats: Uptake inhibition versus release
9. Notes on the serotonergic anorectic agents
10. Progress in assessing the role of serotonin in the control of food intake
11. 3H]dopa in various regions of the brain
12. 3H]serotonin
13. Effects of Lilly 110140, a specific inhibitor of 5-hydroxy-tryptamine uptake, on food intake and on 5-hydroxytryp- tophan-induced anorexia. Evidence for serotoninergic inhibition of feeding
14. 3H]imipramine recognition sites in rat brain by chronic treatment with antidepressants
15. d-, l-, and dl-Fenfluramine cause long-lasting depletions of serotonin in rat brain
16. Sertraline, lS,4S-N-methyl-4-(3,4-dichloro-phenyl)-1, 2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin
17. Pharmacological treatments that affect CNS activity: Serotonin
18. In vivo demethylation of Lilly 110140: 3(p-tri-fluoromethylphenoxyl)-N-methyl-3-phenylpropylamine to an active metabolite—Lilly 10397
19. The pharmacology of serotoninergic drugs affecting appetite
20. Serotonergic mechanisms in feeding
21. Suppression of food intake in rats by fluoxetine: Comparison of enantiomers and effects of serotonin antagonists
22. Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: Pharmacokinetic, dose response, regional specificity and time course data