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Volumn 3, Issue 4, 1992, Pages 521-524

Enzyme assisted preparation of enantiomerically pure β-adrenergic blockers III. Optically active chlorohydrin derivatives and their conversion

Author keywords

[No Author keywords available]

Indexed keywords

ALPRENOLOL; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; MOPROLOL; OXPRENOLOL; PENBUTOLOL; PRACTOLOL; PROPRANOLOL; TOLIPROLOL; TRIACYLGLYCEROL LIPASE;

EID: 0026533671     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/S0957-4166(00)80256-6     Document Type: Article
Times cited : (48)

References (38)
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    • 84912900468 scopus 로고    scopus 로고
    • 2 and DMAP as catalyst
  • 27
    • 84912916373 scopus 로고    scopus 로고
    • supplied by Diacel Chemical Industries, Ltd. or Baker Chemikalien, D-6080 Groß-Gerau, Germany
  • 28
    • 84912911810 scopus 로고    scopus 로고
    • The difficulties in the enzymatic hydrolysis of water insoluble, crystalline esters like (±)-31 have been encountered in numerous cases during our work. Frequently cosolvents can be added to act as mediatois. In this particular case all attemps of this nature were unsuccessful. That the substructure of (±)-31 is in fact accepted by the enzyme is documented by the fact that the esterification of corresponding alcohol (±)-21, carried out in an organic solvent (Scheme 2, Table 2) proceeds with high enantioselectivity.
  • 29
    • 20644469267 scopus 로고
    • Due to the large errors associated with the detection of E-values, all numbers E 〉 100 are of little significance. For all reaction with high enantiomeric ratio therefore E 〉 100 was listed. For comparison the actually calculated vaues are included in brackets.
    • (1982) J. Am. Chem. Soc. , vol.104 , pp. 7294
    • Chen1    Fujimoto2    Girdaukas3    Sih4
  • 36
    • 0012551085 scopus 로고
    • (S)-(−)-1k was prepared from (R)-(−)-3k according to A. M. Barrett, J. Carter, R. Hull, D. J. Le Count and C. J. Squire, (ICI), U.S. Pat. Appl. 3836671 (1974), C. Lane, J. Tramper, M.D. Lilly, Elsevier Science Publishers, Proceedings of an International Symposium held at Wageningen, NL
    • (1987) Biocatalysis in Organic Media , pp. 387
    • Johnstone1    Phillips2    Robertson3    Watts4    Bertola5    Koger6    Marx7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.