Characterization of a novel aquaretic agent, OPC‐31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist

British Journal of Pharmacology

Volumn 105, Issue 4, 1992, Pages 787-791

  Yamamura, Yoshitaka ^a   Ogawa, Hidenori ^a   Yamashita, Hiroshi ^a   Chihara, Tomihiko ^a   Miyamoto, Hisashi ^a   Nakamura, Shigeki ^a   Onogawa, Toshiyuki ^a   Yamashita, Tatsuya ^a   Hosokawa, Tetsumi ^a   Mori, Toyoki ^a   Tominaga, Michiaki ^a   Yabuuchi, Youichi ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

aquaresis; nonpeptide antagonist; OPC 31260; V2 receptor; vasopressin

Indexed keywords

ARGIPRESSIN; DIURETIC AGENT; FUROSEMIDE; HYDROCHLOROTHIAZIDE; MOZAVAPTAN; N [4 [(5 DIMETHYLAMINO 2,3,4,5 TETRAHYDRO 1H BENZAZEPIN 1 YL)CARBONYL]PHENYL] 2 METHYLBENZAMIDE; RECEPTOR BLOCKING AGENT; SPIRONOLACTONE; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR; VASOPRESSIN RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; DIURESIS; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; URINE OSMOLALITY;

ADMINISTRATION, ORAL; ANIMAL; ARGIPRESSIN; BENZAZEPINES; BINDING, COMPETITIVE; CELL MEMBRANE; DIURESIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IN VITRO; KIDNEY; LIVER; MALE; NATRIURESIS; RATS; RECEPTORS, ANGIOTENSIN; RECEPTORS, VASOPRESSIN;

EID: 0026533435     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1992.tb09058.x     Document Type: Article

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