Chymopapain: A 10-year, double-blind study

Spine

Volumn 17, Issue 4, 1992, Pages 388-394

  Gogan, W J ^a   Fraser, R D ^b  

^a Royal Adelaide Hospital ^*  (United States)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Chymopapain; Disc prolepse; Sciatica

Indexed keywords

CHYMOPAPAIN; SODIUM CHLORIDE;

ADULT; AGED; ARTICLE; CHEMONUCLEOLYSIS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISKITIS; FEMALE; HUMAN; INTERVERTEBRAL DISK HERNIA; ISCHIALGIA; LAMINECTOMY; LUMBAR DISK; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; CHYMOPAPAIN; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMAN; INTERVERTEBRAL DISK CHEMOLYSIS; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; SODIUM CHLORIDE; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; TREATMENT OUTCOME;

EID: 0026532945     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/00007632-199204000-00002     Document Type: Article

References (41)

1. Adams P, Eyre DR, Muir H: Biochemical aspects of development and ageing of human lumbar intervertebral discs. Rheumatology and Rehabilitation 16:22-229, 1977
2. Agre K, Wilson RR, Brim M, et al: Chymodiactin postmarketing surveillance: Demographic and adverse experience data in 29, 075 patients. Spine 9:479-485, 1984
3. Alexander AH, Burkus JK, Mitchell JB, Ayers WV: Chymopapain, chemonucleolysis versus surgical discectomy in a military population. Clin Orthop 244:158-165, 1989
4. Brinckmann P, Horst M: The influence of vertebral body fracture, intradiscal injection, and partial discectomy on the radial bulge and height of human lumbar discs. Spine 10:138-145, 1985
5. Brown MD, Daroff RB: The double blind study comparing disease to placebo: An editorial comment. Spine 2:233-236, 1977
6. Bush HD, Horton WG, Smare DL, Naylor A: Fluid content of the nucleus pulposus as a factor in the disk syndrome. Br Med J 14:81-83, 1956
7. Carruthers CC, Kousali KN: Surgical treatment after chemonucleolysis failure. Clin Orthop 165:172-175, 1982
8. Crawshaw C, Frazer AM, Merrian WF: A comparison of surgery and chemonucleolysis in the treatment of sciatica: A prospective randomized trail. Spine 9:195-198, 1984
9. Dabezies EJ, Langford K, Morris J, et al: Safety and efficacy of chymopapain (disease) in the treatment of sciatica due to a herniated nucleus pulposus: Results of a randomised, doubleblind study. Spine 13:561-565, 1988
10. Deyo RA: Chymopapain for herniated intervertebral disc: A methodologic analysis and an agenda for future research. Spine 9:474-478, 1984
11. Dolan P, Adams MA, Hutton WC: The short term effects of chymopapain on intervertebral discs. J Bone Joint Sure 69B:422-428, 1987
12. Ejeskar A, Nachemson A, Herberts P, et al: Surgery versus chemonucleolysis for herniated lumbar discs: A prospective study with random assignment. Clin Orthop 174:236-241, 1983
13. Fraser RD: Chymopapain for the treatment of intervertebral disc herniation: A preliminary report of a double-blind study. Spine 7:608-612, 1982
14. Fraser RD: Chymopapain for the treatment of intervertebral disc herniation: The final report of a double-blind study. Spine 9:815-817, 1984
15. Gorge HH, Brock M, Curio G, Mayer HM: Surgical findings in 50 cases of failed chemonucleolysis with chymopapain. Surg Neurol 25:563-567, 1986
16. Greenough CG, Fraser RD: Low back pain outcome score. 1990 (Submitted for publication)
17. Hendry NGC: The hydration of the nucleus pulposus and its relation to intervertebral disc derangement. J Bone Joint Surg 40B: 132-144, 1958
18. Hirsch G, Galante J: Laboratory conditions for tensile tests in annulus fibrosus from human intervertebral discs. Acta Orthop Scand 38:148-162, 1967
19. Howe J, Frymoyer JW: The effects of questionnaire design on the determination of end results in lumbar spinal surgery. Spine 10:804-805, 1985
20. Javid MJ: Efficacy of chymopapain, chemonucleolysis: A long-term review of 105 patients. J Neurosurg 62:662-666, 1985
21. Javid MJ, Nordby EJ, Ford LT, et al: Safety and efficacy of chymopapain (chymodiactin) in herniated nucleus pulposus with sciatica: Results of a randomized, double-blind study. JAMA 249:2489-2494, 1983
22. Lancet Editorial: Chymopapain and the intervertebral disc. The Lancet 2:843-845, 1986
23. Leavitt F, Garron DC, Whisler WE, et al: A comparison of patients treated by chymopapain and laminectomy for low back pain using a multidimensional pain scale. Clin Orthop 146:136-143, 1980
24. Maciunas RJ, Onofrio BM: The longterm results of chymo-papain chemonucleolysis for lumbar disc disease. J Neurosurg 65:1-8, 1986
25. Maciunas RJ, Onofrio BM: Letter. J Neurosurg 65:884, 1986
26. Maroon JC, Abla A: Microdiscectomy versus chemonucleolysis. J Neurosurg 16:644-649, 1985
27. Martins AN, Ramirez A, Johnston J, Schwetschenau PR: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. J Neurosurg 49:816-827, 1978
28. McCulloch JA, Macnab I: Sciatica and Chymopapain. Baltimore, Williams and Wilkins, 1983
29. Morris J, Stromberg L: Double-blind study of disease (chymopapain) versus C.E.I. (chymopapain activator) in the treatment of herniated nucleus pulposus in the lumbar spine. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Cambridge, England, 1983
30. Nordby EJ, Lucas GL: A comparative analysis of lumbar disc disease treated by laminectomy or chemonucleolysis. Clin Orthop 90:119-129, 1973
31. Onofrio BM: Injection of chymopapain into intervertebral discs: Preliminary report on 72 patients with symptoms of disc disease. J Neurosurg 42:384-388, 1975
32. Postacchini F, Lami R, Massobrio M: Chemonucleolysis versus surgery in lumbar disc herniations: Correlation of the results to preoperative clinical pattern and size of the herniation. Spine 12:87-96, 1987
33. Schwetschenau PR, Ramirez A, Johnston J, Wiggs C, Martins AN: Double-blind evaluation of intradiscal chymopapain for herniated lumbar discs: Early results. J Neurosurg 45:622-627, 1976
34. Travenol Laboratories: Unpublished data, 1980
35. Tregonning GD, Transfeldt EE, McCulloch JA, Macnab I, Nachemson A: Chymopapain versus conventional surgery for lumbar disc herniation. J Bone Joint Surg 73B:481-486, 1991
36. Urban JPG, Maroudas A: Swelling of the intervertebral disc in vitro. Connect Tissue Res 9:1-10, 1981
37. van Alphen HAM, Braakman R, Bezemer PD et al: Chemo-nucleolysis versus discectomy: A randomised multicentred trial. J Neurosurg 70:869-875, 1989
38. Watters WC, Mirkovic S, Boss J: Treatment of the isolated lumbar intervertebral disc herniation: Microdiscectomy versus chemonucleolysis. Spine 13:360-361, 1988
39. Weber H: Lumbar disc herniation. Spine 8:131-140, 1983
40. Wiltse LL, Widdell EH Jr, Yuan HA: Chymopapain chemo-nucleolysis in lumbar disk disease. JAMA 231:474-479, 1975
41. Zeiger HE: Comparison of chemonucleolysis and microsurgical discectomy for the treatment of herniated lumbar disc. Spine 12:796-799, 1987