Isoforms of the CD45 common leukocyte antigen family: Markers for human T-cell differentiation

Journal of Clinical Immunology

Volumn 12, Issue 1, 1992, Pages 1-10

  Clement, Loran T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD45 isoforms; common leukocyte antigens; Lymphocyte differentiation; T cell subpopulations

Indexed keywords

CD45 ANTIGEN; LEUKOCYTE ANTIGEN;

ADULT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY CELL; NORMAL HUMAN; ONTOGENY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD; ANTIGENS, CD45; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; BONE MARROW TRANSPLANTATION; FETAL BLOOD; HISTOCOMPATIBILITY ANTIGENS; HUMAN; IMMUNOLOGIC DEFICIENCY SYNDROMES; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MEMBRANE GLYCOPROTEINS; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 0026527127     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/BF00918266     Document Type: Article

References (84)

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2. Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens
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7. A second signal for T cell mitogenesis provided by monoclonal antibodies CD45 (T200)
8. Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL-2 receptor expression
9. Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
10. Association of CD2 and CD45 on human T lymphocytes
11. Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase
12. CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells
13. CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells
14. Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phophotyrosine phosphatase
15. The tissue distribution of T lymphocytes expressing different CD45 polypeptides
16. In situ localization of CD45 isoforms in the human thymus indicates a medullary location for the thymic generative lineage
17. Selective expression of CD45 isoforms and of maturation antigens during human thymocyte differentiation: Observations and hypothesis
18. Interleukin-4 induces expression of the CD45RA antigen on human thymocyte subpopulations
19. CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis
20. Definition of the thymic generative lineage by selective expression of high molecular weight isoforms of CD45 (T200)
21. Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population
22. The isolation and characterization of the human suppressor inducer T cell subset
23. Predominance of “memory” T cells (CD4+, CD29+) over “naive” T cells (CD4+, CD45R+) in both normal and diseased skin
24. Leucocyte common antigen expression on T cells in normal and inflamed human gut
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27. Differential activation requirements for virgin and memory T cells
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29. CD4+CD45RA cells are preferentially activated through the CD2 pathway
30. Regulatory interactions between members of the immunoglobulin superfamily
31. Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation
32. Virgin and memory T cells have different requirements for activation via the CD2 molecule
33. Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations
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36. Generation of CD8 (T8) cytotoxic cells has a preferential requirement for CD4+2H4− inducer cells
37. Induction of suppression following autologous mixed lymphocyte reaction: Role of a novel 2H4 antigen
38. Functional characterization of the CD45R(2H4) molecule on CD8(T8) cells in the AMLR system
39. Immunoregulatory T lymphocytes in man: Soluble antigen-specific suppressor-inducer T lymphocytes are derived from the CD4+CD45R-p80+ subpopulation
40. T cell regulation of human B cell proliferation and differentiation. Regulatory influences of CD45R+ and CD45R− T4 cell subsets
41. Identification and isolation of OKT4+ suppressor cells with the monoclonal antibody WR16
42. Delineation of suppressor and helper activity within the OKT4-defined T lymphocyte subset in human newborns
43. Novel immunoregulatory functions of phenotypically distinct subpopulations of CD4+ cells in the human neonate
44. Phenotypic characterization of the post-thymic differentiation of human alloantigen-specific CD8+ cytotoxic T lymphocytes
45. The synergy between naive and memory T cells during activation
46. The functional heterogeneity of CD8+ cells defined by anti-CD45RA (2H4) and anti-CD29 (4B4) antibodies
47. Functional diversity of T lymphocytes due to secretion of different cytokine patterns
48. Restricted production of interleukin 4 by activated human T cells
49. Two subsets of human CD4+ T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-τ can be defined by the Leu-18 and UCHL1 monoclonal antibodies
50. Human memory lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-τ production
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54. Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor
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56. Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event
57. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
58. The functionally distinct subpopulations of human helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation
59. The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype
60. Transition from high to low molecular weight isoforms of CD45 (T200) involve a rapid activation of alternate mRNA splicing and slow turnover of surface CD45R
61. Phenotypic and functional characterization of tumor infiltrating lymphocytes in mycosis fungoides: Continuous growth of CD4+CD45R+ T cell clones with suppressor-inducer activity
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63. Lymphokine regulation of CD45R expression on human T cell clones
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68. The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions
69. A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody
70. Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritis
71. Abnormal distribution of the helper-inducer and suppressor-inducer T lymphocyte subsets in the rheumatoid joint
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73. Suppressor-inducer cells in multiple sclerosis
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76. Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases
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78. Bare lymphocyte syndrome: Consequences of absent class II major histocompatibility antigen expression for B lymphocyte differentiation and function
79. Subset alteration in HIV-infected homosexual men—NIAID Multicenter AIDS Cohort study
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81. Genetically determined lack of CD45R− T cells in healthy individuals. Evidence for a regulatory polymorphisms of CD45R antigen expression
82. T cell reconstitution of SCID recipients grafted with T-depleted bone marrow