Ploidy of lymphoblasts is the strongest predictor of treatment outcome in b-progenitor cell acute lymphoblastic leukemia of childhood: A pediatric oncology group study

Journal of Clinical Oncology

Volumn 10, Issue 4, 1992, Pages 606-613

  Trueworthy, R ^a,o   Shuster, J ^b   Look, T ^c   Crist, W ^d   Borowitz, M ^e   Carroll, A ^f   Frankel, L ^g   Harris, M ^h   Wagner, H ⁱ   Haggard, M ^j   Mosijczuk, A ^k   Pullen, J ^l   Steuber, P ^m   Land, V ⁿ  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g TEXAS A M COLLEGE OF MEDICINE   (United States)

^h HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

ⁱ Swiss Pediatric Oncology Group   (Switzerland)

^j UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^k FITZSIMONS ARMY MEDICAL CENTER   (United States)

^l UNIVERSITY OF MISSISSIPPI   (United States)

^m BAYLOR COLLEGE OF MEDICINE   (United States)

ⁿ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o Pediatric Oncology Group   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYTARABINE; HYDROCORTISONE; IMMUNOGLOBULIN G; MEMBRANE ANTIGEN; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE; ANTIGEN EXPRESSION; ARTICLE; CANCER CHEMOTHERAPY; CHILD; CHILDHOOD LEUKEMIA; DNA CONTENT; FEMALE; FLOW CYTOMETRY; HIGH RISK PATIENT; HUMAN; HUMAN CELL; INTRATHECAL DRUG ADMINISTRATION; LEUKEMIA CELL; LEUKOCYTE COUNT; LYMPHOBLAST; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; STEM CELL;

ADOLESCENT; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; B-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; DNA, NEOPLASM; HUMAN; INFANT; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKOCYTE COUNT; PLOIDIES; REGRESSION ANALYSIS; RISK FACTORS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR STEM CELLS;

EID: 0026518781     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1992.10.4.606     Document Type: Article

References (17)

1. Crist WM, Pullen DJ, Rivera GK: Acute lymphoid leukemia, in Fernbach DJ, Vietti TJ (eds): Clinical Pediatric Oncology (ed 4). St Louis, MO, Mosby Year Book, 1991
2. Pui C-H, Behm FG, Raimondi SC, et al: Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N Engl J Med 321:136-142, 1989
3. Lipshultz SE, Colan SD, Gelber RD, et al: Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. N Engl J Med 324:808-814, 1991
4. Crist W, Boyett J, Pullen J, et al: Clinical and biologic features predict poor prognosis in acute lymphoid leukemias in children and adolescents. A Pediatric Oncology Group review. Med Pediatr Oncol 14:135-139, 1986
5. Pui C-H, Crist WM: High risk lymphoblastic leukemia in children: Prognostic factors and management. Blood Rev 1:25-33, 1987
6. Borowitz MJ, Shuster JJ, Civin CI, et al: Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: A Pediatric Oncology Group study. J Clin Oncol 8:1389-1398, 1990
7. Look AT, Roberson PK, Williams DL, et al: Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. Blood 65:1079-1086, 1985
8. Crist WM, Carroll AJ, Shuster JJ, et al: Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): A Pediatric Oncology Group study. Blood 76:117-122, 1990
9. Pui C-H, Frankel LS, Carroll AJ, et al: Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): A collaborative study of 40 cases. Blood 77:440-447, 1991
10. Williams DL, Tsiatis A, Brodeur GM, et al: Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. Blood 60:864-872, 1982
11. Williams DL, Harber J, Murphy SB, et al: Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia. Blood 68:205-212, 1986
12. Pui C-H, Carroll AJ, Raimondi SC, et al: Clinical preparation, karyotypic characterization and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid < 45 line. Blood 75:1170-1177, 1990
13. Seeker-Walker LM, Lawler SD, Hardisty RM: Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis. Br Med J 2:1529-1530, 1978
14. Swansbury GJ, Secker-Walker LM, Lawler SD, et al: Chromosomal findings in acute lymphoblastic leukaemia of childhood: An independent prognostic factor. Lancet 2:249-250, 1981
15. Bloomfield CD, Lindquist LL, Arthur D, et al: Chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Res 41:4838-4843, 1981
16. Pui C-H, Williams DL, Raimondi SC, et al: Hypoploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia. Blood 70:247-253, 1987
17. Pui C-H, Raimondi SC, Dodge RK, et al: Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (< 50 chromosomes) acute lymphoblastic leukemia. Blood 73:1963-1967, 1989