Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism: Connection with amplified cytokine release

Journal of Clinical Investigation

Volumn 89, Issue 3, 1992, Pages 851-860

  Bernard, Catherine ^a   Szekely, Barbara ^a   Philip, Ivan ^a   Wollman, Emmanuelle ^b   Payen, Didier ^c   Tedgui, Alain ^a,d  

^a Inst Natl de la S et de la R M   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d INSERM   (France)

Author keywords

Anion superoxide; Cytokines; Endothelium; Lipopolysaccharide; Nitric oxide

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; RABBIT;

ANIMAL; ANTIOXIDANTS; ARGININE; CAROTID ARTERIES; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; ENDOTHELIUM, VASCULAR; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; RABBITS; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR; VASOCONSTRICTION;

EID: 0026517255     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115664     Document Type: Article

References (5)

1. Groeneveld, A. B., J. J. P. Naula, and L. G. Thijs. 1988. Peripheral vascular resistance in septic shock: its relation to outcome. Intensive Care Med. 14:141-147.
2. Freudenberg, M. A., D. Keppler, and C. Galanos. 1986. Requirement for lipopolysaccharide-sensitise macrophages in galactosamine-induced sensitization to endotoxin. Infect. Immun. 51:891-895.
3. Nathan, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79:319-326.
4. Mathison, J. C., E. Wolfson, and R. J. Ulevitch. 1988. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolssaccharide-induced injury in rabbits. J. Clin. Invest. 81:1925-1937.
5. Okusasva, S., J. A. Gelfand, T. Ikejima, R. J. Connolly, and C. A. Dinarello. 1988. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J. Clin. Invest. 81:1162-1172.