p53 Mutations in Human Malignant Gliomas: Comparison of Loss of Heterozygosity with Mutation Frequency

Cancer Research

Volumn 52, Issue 6, 1992, Pages 1427-1433

  Frankel, Roger H ^a   Bayona, William ^b   Koslow, Maxim ^b   Newcomb, Elizabeth W ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; CHROMOSOME 17P; CLINICAL ARTICLE; EXON; FEMALE; GENE DELETION; GENE MUTATION; GLIOBLASTOMA; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; MUTATION RATE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; ALLELES; AMINO ACID SEQUENCE; BLOTTING, SOUTHERN; BRAIN NEOPLASMS; CHILD; CHROMOSOMES, HUMAN, PAIR 17; CODON; FEMALE; GENES, P53; GENES, RETINOBLASTOMA; GLIOMA; HETEROZYGOTE; HUMAN; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM (GENETICS); POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026517069     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Knudson, A. G. Hereditary cancer, oncogenes, and anti-oncogenes. Cancer Res., 45:1437-1443,1985.
2. Seemayer, T. A., and Cavenee, W. K. Molecular mechanisms of oncogenesis. Lab. Invest., 60:585-599,1989.
3. Lane, D. P., and Benchimol, S. p53: oncogene or anti-oncogene? Genes & Dev., 4:1-8, 1990.
4. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 253:49-53,1991.
5. Levine, A. J., Momand, J., and Finlay, C. A. The p53 tumour suppressor gene. Nature (Lond.), 351:453-456,1991.
6. Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., and Dryja, T. P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (Lond.), 323:643-646,1986.
7. Isobe, M., Emanuel, B. S., Givol, D., Oren, M., and Croce, C. M. Localization of gene for human p53 tumour antigen to band 17p13. Nature (Lond.), 320: 84-85,1986.
8. McBride, O. W., Merry, D., and Givol, D. The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13). Proc. Natl. Acad. Sci. USA, 83:130-134,1986.
9. Silverberg, E., Boring, C. C., and Squires, B. A. Cancer statistics, 1990. CA Cancer J. Cin., 40:9-26,1990.
10. Kornblith, P. C., Walker, M. D., and Cassady, J. R. Pathology of central nervous system tumors. Itu Neurological Oncology, pp. 35-48. Philadelphia: J. B. Lippincott & Co., 1987.
11. James, C. D., Carlbom, E., Dumanski, J. P., Hansen, M., Nordenskjold, M., Collins, V. P., and Cavenee, W. K. Clonal genomic alterations in glioma malignancy stages. Cancer Res., 48:5546-5551, 1988.
12. James, C. D., Carlbom, E., Nordenskjold, M., Collins, V. P., and Cavenee, W. K. Mitotic recombination of chromosome 17 in astrocytomas. Proc. Natl. Acad. Sci. USA, 86:2858-2862,1989.
13. James, C. D., He, J., Carlbom, E., Nordenskjold, M., Cavanee, W. K., and Collins, V. P. Chromosome 9 deletion mapping reveals interferon a and interferon β-1 gene deletions in human glial tumors. Cancer Res., 57:1684-1688,1991.
14. Fults, D., Tippets, R. H., Thomas, G. A., Nakamura, Y., and White, R. Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Res., 49:6572-6577,1989.
15. Fults, D., Pedone, C. A., Thomas, G. A., and White, R. Allelotype of human malignant astrocytoma. Cancer Res., SO: 5784-5789,1990.
16. El-Azouzi, M., Chung, R. Y., Farmer, G. E., Martuza, R. L., Black, P. M. L., Rouleau, G. A., Hettlich, C., Hedley-Whyte, E. T., Zervas, N. T., Panago-poulos, K., Nakamura, Y., Gusella, J. F., and Seizinger, B. R. Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc. Natl. Acad. Sci. USA, 86:7186-7190, 1989.
17. Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Collins, F. S., Weston, A., Modali, R., Harris, C. C., and Vogelstein, B. Mutations in the p53 gene occur in diverse human tumour types. Nature (Lond.), 342:705-708,1989.
18. Venter, D. J., Bevan, K. L., Ludwig, R. L., Riley, T. E. W., Jat, P. S., Thomas, D. G. T., and Noble, M. D. Retinoblastoma gene deletions in human glioblastomas. Oncogene, 6:445-448,1991.
19. Baker, S. J., Preisinger, A. C., Jessup, J. M., Paraskeva, C., Markowitz, S., Willson, J. K. V., Hamilton, S., and Vogelstein, B. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res., 50:7717-7722,1990.
20. Burger, P. C., Scheithauer, B. W., and Vogel, F. S. Brain tumors. In: Surgical Pathology of the Nervous System and Its Coverings, Ed. 3, pp. 193-404. New York: Churchill Livingstone, 1991.
21. Miller, S. A., Dykes, D. D., and Polesky, H. F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res., 16: 12-15.1988.
22. Gaidano, G., Ballerini, P., Gong, J. Z., Inghirami, G., Neri, A., Newcomb, E. W., Magrath, I. T., Knowles, D. M., and Dalla-Favera, R. p53 mutations in human lymphoid malignancies: association with Burkitt's lymphoma and chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA, 88:5413-5417, 1991.
23. Nakamura, Y., Ballard, L., Leppert, M., O'Connell, P., Lathrop, G. M., Lalouel, J. M., and White, R. Isolation and mapping of a polymorphic DNA sequence (pYNZ22) on chromosome 17p [D17S30]. Nucleic Acids Res., 16: 5707.1988.
24. Kondoleon, S., Vissing, H., Luo, X. Y., Magenis, R. E., Kellog, J., and Litt, M. A hypervariable RFLP on chromosome 17p13 is defined by an arbitrary single copy probe pl44-D6 [HGM9NoD17S34]. Nucleic Acids Res., 15: 10605,1987.
25. Soussi, T., Caron de Fromentel, C., and May, P. Structural aspects of the p53 protein in relation to gene evolution. Oncogene, 5: 945-952,1990.
26. Chiba, I., Takahashi, T., Nau, M. M., D'Amico, D., Curiel, D. T., Mitsudomi, T., Buchhagen, D. L., Carbone, D., Piantadosi, S., Koga, H., Reissman, P. T., Slamon, D. J., Holmes, E. C., and Minna, J. D. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene, 5:1603-1610,1990.
27. Hsu, 1. C., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., and Harris, C. C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature (Lond.), 350:427-428,1991.
28. Bressac, B., Kew, M., Wands, J., and Ozturk, M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature (Lond.), 350:429-431,1991.
29. Hollstein, M. C., Peri, L., Mandard, A. M., Welsh, J. A., Montesano, R., Metcalf, R. A., Balt, M., and Harris, C. C. Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations. Cancer Res., 57:4102-4106, 1991.
30. Orita, M., Susuki, Y., Sekiya, T., and Hayashi, K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics, 5: 874-879,1989.
31. Serra, A., Gaidano, G. L., Revello, D., Guerrasio, A., Ballerini, P., Dalla-Favera, R., and Saglioi, G. A new Taql polymorphism in the p53 gene. Nucleic Acids Res., 20:928,1992.
32. Matlashewski, G. J., Tuck, S., Pim, D., Lamb, P., Schneider, J., and Crawford, L. V. Primary structure polymorphism at amino acid residue 72 of human p53. Mol. Cell. Biol., 7: 961-963,1987.
33. Murakami, Y., Hayashi, K., and Sekiya, T. Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis. Cancer Res., 51:3356-3361,1991.
34. Bigner, S. H., and Vogelstein, B. Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma. Brain Pathol., 1:12-18,1990.
35. Tamura, G., Kihana, T., Nomura, K., Terada, M., Sugimura, T., and Hirohashi, S. Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis. Cancer Res., 51:3056-3058,1991.
36. Saylors, R. L., Sidransky, D., Friedman, H. S., Bigner, S. H., Bigner, D. D., Vogelstein, B., and Brodeur, G. M. Infrequent p53 gene mutations in medulloblastomas. Cancer Res., 51:4721-4723.1991.
37. Olumi, A. F., Tsai, Y. C., Nichols, P. W., Skinner, D. G., Cain, D. R., Bender, L. I., and Jones, P. A. Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder. Cancer Res., 50:7081-7083,1990.
38. Sano, T., Tsujino, T., Yoshida, K., Nakayama, H., Haruma, K., Ito, H., Nakumura, Y., Kajiyama, G., and Tahara, E. Frequent loss of heterozygosity on chromosomes lq, 5q, and 17p in human gastric carcinomas. Cancer Res., 57:2926-2931,1991.
39. Riccardi, V. M. von Recklinghausen neurofibromatosis. N. Engl. J. Med., 305:1617-1627,1981.
40. Menon, A. G., Anderson, K. M., Riccardi, V. M., Chung, R. Y., Whaley, J. M., Yandell, D. W., Farmer, G. E., Freiman, R. N., Lee, J. K., Li, F. P., Barker, D. F., Ledbetter, D. H., Kleider, A., Martuza, R. L., Gusella, J. F., and Seizinger, B. R. Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis. Proc. Natl. Acad. Sci. USA, 87: 5435-5439, 1990.
41. Ohgaki, H., Eibl, R. H., Wiestler, O. D., Yasargil, M. G., Newcomb, E. W., and Kleihues, P. p53 mutations in nonastrocytic human brain tumors. Cancer Res., 57:6202-6205,1991.
42. Iggo, R., Gatter, K., Bartek, J., Lane, D., and Harris, A. L. Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet, 555:675-679,1990.
43. Bartek, J., Iggo, R., Gannon, J., and Lane, D. P. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene, 5: 893-899,1990.
44. Prosser, J., Thompson, A. M., Cranston, G., and Evans, H. J. Evidence that p53 behaves as a tumor suppressor gene in sporadic breast tumors. Oncogene, 5:1573-1579,1990.
45. Casson, A. G., Mukhopadhyay, T., Cleary, K. R., Ro, J. Y., Levin, B., and Roth, J. A. p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res., 57:4495-4499,1991.
46. Herskowitz, I. Functional inactivation of genes by dominant negative mutations. Nature (Lond.), 329:219-222,1987.
47. Finlay, C. A., Hinds, P. W., Tan, T. H., Eliyahu, D., Oren, M., and Levine, A. J. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol., 8:531-539,1988.
48. Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhash-Kimhi, O., and Oren, M. Wildtype p53 can inhibit oncogene mediated focus formation. Proc. Natl. Acad. Sci. USA, 86:8763-8767,1989.
49. Milner, J., and Medcalf, E. A. Cotranslation of activated mutant p53 with wild-type drives the wild-type p53 protein into the mutant conformation. CeU, 65:765-774, 1991.
50. Lee, E.Y-H.P., To, H., Shew, J. Y., Bookstein, R., Scully, P., and Lee, W. H. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science (Washington DC), 241:218-221,1988.
51. TAng, A., Varley, J. M., Chalcraborty, S., Murphree, A. L., and Fung, Y-K. T. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science (Washington DC), 242:263-266,1988.
52. Cheng, J., Scully, P., Shew, J-Y., Lee, W-H., Vila, V., and Haas, M. Homozygous deletion of the retinoblastoma gene in an acute lymphoblastic leukemia (T) cell line. Blood, 75:730-735,1990.
53. Ginsberg, A. M., Raffeld, M., and Cossman, J. Inactivation of the retinoblastoma gene in human lymphoid neoplasms. Blood, 77:833-840,1991.
54. Horowitz, J. M., Yandell, D. W., Park, S-H., Canning, S., Whyte, P., Buchkovich, K., Harlow, E., Weinberg, R. A., and Dryja, T. P. Point mutational inactivation of the retinoblastoma antioncogene. Science (Washington DC), 243:937-940.1989.
55. Trent, J., Meltzer, P., Rosenblum M., Harsh, G., Kinzler, K., Mashal, R., Feinberg, A., and Vogelstein, B. Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proc. Natl. Acad. Sci. USA, 83:470-473, 1986.
56. Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O'Brien, S. J., Wong, A. J., and Vogelstein, B. Identification of an amplified, highly expressed gene in a human glioma. Science (Washington DC), 236: 70-73,1987.
57. Liebermann, T. A., Nusbaum, H. R., Razon, N., Kris, R., Lax, I., Soreq, H., Whittle, N., Waterfield, M. D., Ullrich, A., and Schlessinger, J., Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin. Nature (Lond.), 575: 144-147, 1985.
58. Wong, A. J., Bigner, S. H., Bigner, D. D., Kinzler, K. W., Hamilton, S. R., and Vogelstein, B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. USA, 84:6899-6903,1987.
59. Ekstrand, A. J., James, C. D., Cavenee, W. K., Seliger, B., Pettersson, R. F., and Collins, V. P. Genes for epidermal growth factor receptor, transforming growth factor a, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res., 57:2164-2172,1991.