Lactational transfer of 3,3′,4,4′-tetrachloro-and 2,2′,4,4′,5,5′-hexachlorobiphenyl induces cytochrome P450IVA1 in neonates. Evidence for a potential synergistic mechanism

Biochemical Pharmacology

Volumn 43, Issue 2, 1992, Pages 153-157

  Borlakoglu, J T ^c,d   Clarke, S ^a   Huang, SheWen ^b   Dils, R R ^c   Haegele, K D ^d   Gibson, G G ^b  

^a SANOFI   (France)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 3,3',4,4' TETRACHLOROBIPHENYL; CYTOCHROME P450 ISOENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME INDUCTION; FEMALE; LACTATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANIMALS, NEWBORN; BIOLOGICAL TRANSPORT; COMPARATIVE STUDY; CYTOCHROME B5; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; LACTATION; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; POLYCHLORINATED BIPHENYLS; RATS; SUPPORT, NON-U.S. GOV'T;

EID: 0026516648     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(92)90272-K     Document Type: Article

References (24)

1. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action
2. Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity
3. Immunochemical quantitation of cytochrome P450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats
4. Evidence for the induction of cytochrome P452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs)
5. The effect of peroxisome proliferators on microsomal and mitochondrial enzyme activities in the liver and kidney
6. Chemical contaminants in human milk
7. A convenient new method of aromatic hydroxylation
8. Effect of molecular substitution patterns on the cytochrome P450 dependent metabolism of 2,2',3,5,5',6 and 2,2',3,4,4',6-hexachlorobiphenyl by rat liver microsomal monooxygenases
9. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
10. Protein measurement with the Folin phenol reagent
11. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues. A series of substrates to distinguish between different induced cytochromes P450
12. Effect of polychlorinated biphenyls in suckling mice by N-nitrosadimethylamine
13. Enhancement of fatty acylCoA oxidizing activity in rat liver peroxisomes by di-(2-ethylhexyl)phtalate
14. Acyl CoA oxidase of rat liver: a new enzyme for fatty acid oxidation
15. Catalase
16. Microsomal cytochrome P452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver
17. Differential induction of peroxisomal and microsomal fatty-acid-oxidising enzymes by peroxisome proliferators in rat liver and kidney. Characterisation of a renal cytochrome P450 and implications for peroxisome proliferation
18. Studies on the structure-activity relationships for the metabolism of polybrominated biphenyls by rat liver microsomes
19. P450 genes: structure, evolution and regulation
20. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
21. In vitro chromosome damage due to PCB interactions
22. Transfer of persistent chemicals in milk
23. Similarity of the cognitive deficity following perinatal led or PCB exposure to cognitive deficit following selective brain lesions