Preformed ribozyme destroys tumour necrosis factor mRNA in human cells

Journal of Molecular Biology

Volumn 223, Issue 4, 1992, Pages 831-835

  Sioud, Mouldy ^a,b   Natvig, Jacob B ^a   Førre, Øystein ^c  

^a UNIVERSITY OF OSLO   (Norway)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^c Rheumatism Hospital   (Norway)

Author keywords

ribozyme; stability; tumour necrosis factor

Indexed keywords

LIPOSOME; MESSENGER RNA; RIBOZYME; TUMOR NECROSIS FACTOR;

BACTERIOPHAGE T7; ENZYME ACTIVITY; ENZYME STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NOTE; PRIORITY JOURNAL; RNA DEGRADATION;

BASE SEQUENCE; HUMAN; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; RNA, CATALYTIC; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; TUMOR NECROSIS FACTOR;

EID: 0026513691     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(92)90244-E     Document Type: Article

References (22)

1. Tumour necrosis, cachexia, shock, and inflammation: a common mediator
2. The biology of cachectin/TNF. A primary mediator of the host response
3. Inhibitory effect of TNFα antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
4. Expression of mRNA electroporated into plant and animal cells
5. Specific gene suppression by engineered ribozymes in monkey cells
6. The chemistry of self-splicing RNA and RNA enzymes
7. Single step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction
8. Ribozyme mediated destruction of RNA in vivo
9. Differential regulation of lymphotoxin and tumor necrosis factor genes in human T lymphocytes
10. Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
11. Simple RNA enzymes with new and highly specific endoribonuclease activities
12. Cationic liposome-mediated RNA transfection
13. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
14. An antibody against secretogranin I (chromogranin B) is packaged into secretory granules
15. Vectors for selective expression of cloned DNAs by T7 RNA polymerase
16. Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression
17. Ribozymes correctly cleave a model substrate and endogenous RNA in vivo
18. Ribozymes as potential anti-HIV-1 therapeutic agents
19. Interleukin 1, tumour necrosis factor, and interleukin 6 as mediators of cartilage destruction
20. Prevention of human immunodeficiency virus type 1 integrase expression in Escherichia coli by a ribozyme
21. The Vδ gene usage by freshly isolated T lymphocytes from synovial fluids in rheumatoid synovitis: a preliminary report
22. A small catalytic oligoribo-nucleotide