The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved Permeability

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 9, Issue 3, 1992, Pages 435-439

  Conradi, Robert A ^a   Hilgers, Alien R ^a   Ho, Norman F H ^a   Burton, Philip S ^a  

^a PFIZER INC   (United States)

Author keywords

cell culture; hydrogen bonding; lipophilicity; peptide; permeability; transport

Indexed keywords

ACETYL DEXTRO PHENYLALANYL DEXTRO PHENYLALANYL DEXTRO PHENYLALANINAMIDE; ACETYL DEXTRO PHENYLALANYL DEXTRO PHENYLALANYL N METHYL DEXTRO PHENYLALANINAMIDE; ACETYL DEXTRO PHENYLALANYL N METHYL DEXTRO PHENYLALANYL N METHYL DEXTRO PHENYLALANINAMIDE; ACETYL N METHYL DEXTRO PHENYLALANYL N METHYL DEXTROPHENYLALANYL N METHYL DEXTRO PHENYLALANINAMIDE; PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL MEMBRANE; CHEMICAL STRUCTURE; INTESTINE MUCOSA; LIPOPHILICITY; MEMBRANE PERMEABILITY; MODEL; NONHUMAN; PARTITION COEFFICIENT; TRANSPORT KINETICS;

CARBON RADIOISOTOPES; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; INTESTINAL MUCOSA; PEPTIDES;

EID: 0026513211     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1015867608405     Document Type: Article

References (18)

1. The influence of peptide structure on transport across Caco-2 cells
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4. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal permeability
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12. 50 Years of hydrogen bond theory
13. The strength of hydrogen bonding: Infrared spectroscopy
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