Mechanism of the vasodilator action of calcitonin gene‐related peptide in conscious rats

British Journal of Pharmacology

Volumn 106, Issue 1, 1992, Pages 45-48

  Abdelrahman, Aly ^a   Wang, Yong‐Xiang ^a   Chang, Sylvia Diana ^a   Pang, Catherine C Y ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Calcitonin gene related peptide (CGRP); glibenclamide; KATP channel; NG nitro d arginine methyl ester (d NAME); NG nitro l arginine methyl ester (l NAME); nitric oxide synthase inhibitor; nitroprusside; pinacidil

Indexed keywords

ALPHA CALCITONIN GENE RELATED PEPTIDE; GLIBENCLAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PINACIDIL; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMAL; ANTIHYPERTENSIVE AGENTS; ARGININE; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; GLYBURIDE; GUANIDINES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE; PHENYLEPHRINE; PINACIDIL; POTASSIUM CHANNELS; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; VASODILATOR AGENTS;

EID: 0026511037     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1992.tb14290.x     Document Type: Article

References (20)

1. Glibenclamide fails to reverse relaxations induced by calcitonin gene related peptide (CGRP) in human mammary artery and saphenous vein
2. Calcitonin gene‐related peptide is a potent vasodilator
3. Systemic and regional haemodynamic effects of calcitonin gene‐related peptide
4. G‐nitro‐l‐arginine methyl ester in conscious rats
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6. Calcitonin gene‐related peptide (CGRP) endothelium dependent relaxation in rat aorta is inhibited by l‐NMMA.
7. Human α‐calcitonin gene‐related peptide (CGRP) relaxes rat thoracic aorta by releasing nitric oxide and raises cyclic AMP and cyclic GMP.
8. Calcitonin gene‐related peptide (CGRP) is a potent non‐endothelium‐dependent inhibitor of coronary vasomotor tone
9. Calcitonin gene‐related peptide is the endogenous mediator of nonadrenergic‐noncholinergic vasodilation in rat mesentry
10. Role of calcitonin gene related peptide containing nerves in the vascular adrenergic neurotransmission
11. Calcitonin gene‐related peptide stimulates cyclic AMP formaton in rat aortic smooth muscle cells
12. Calcitonin gene‐related peptide vasodilation of human pulmonary vessels
13. + channels
14. Actions of constrictor (NPY and endothelin) and dilator (substance P, CGRP and VIP) peptides on pig splenic and human skeletal muscle arteries: involvement of endothelium
15. Heterogeneous involvement of endothelium in calcitonin gene‐related peptide‐induced relaxation in coronary arteries from rat
16. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
17. Cardiovascular effects of rat calcitonin gene‐related peptide in the conscious rat
18. + channels in arterial smooth muscle
19. G‐nitro‐arginine in conscious rats are antagonized by L‐ but not D‐arginine
20. Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle