Distinct Mechanisms of Differentiation of SH‐SY5Y Neuroblastoma Cells by Protein Kinase C Activators and Inhibitors

Journal of Neurochemistry

Volumn 58, Issue 4, 1992, Pages 1191-1198

  Leli, Ubaldo ^a,c   Cataldo, Anne ^a,c   Shea, Thomas B ^a,c   Nixon, Ralph A ^a,b,c   Hauser, George ^a,b,c  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Department of Psychiatry ^*

Author keywords

Cytoskeleton; Differentiation; Neuroblastoma; Phorbol esters; Protein kinase C; Staurosporine

Indexed keywords

DIACYLGLYCEROL; PHORBOL ESTER; PROTEIN KINASE C; STAUROSPORINE;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL;

ALKALOIDS; CELL DIFFERENTIATION; DIGLYCERIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMAN; NEUROBLASTOMA; PROTEIN KINASE C; STAUROSPORINE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0026509489     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1992.tb11328.x     Document Type: Article

References (39)

1. Functional differentiation of human ganglion cell derived neuroblastoma cell line SH‐SY5Y induced by a phorbol ester (TPA)
2. Isolation and characterization of PKC‐L, a new member of the protein kinase C‐related gene family specifically expressed in lung, skin, and heart
3. Morphology and growth, tumorigenicity and cytogenetics of human neuroblastoma cells in continuous culture
4. The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state
5. Two‐stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns
6. Direct activation of calcium‐activated, phospholipid‐dependent protein kinase by tumor promoting phorbol esters
7. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin
8. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways
9. Temporal and topographic relationships between the phosphorylated and non‐phosphorylated epitopes of the 200 kDa neurofilament protein during development in vitro
10. Structure–activity relationship in diterpene esters irritant and co‐carcinogenic to mouse skin
11. Differentiation‐associated decrease in muscarinic receptor sensitivity in human neuroblastoma cells
12. Protein kinase C activation and down‐regulation in relation to phorbol ester–induced differentiation of SH‐SY5Y human neuroblastoma cells
13. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C–related gene family
14. Use of avidin‐biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures
15. Decline in c‐myc mRNA expression but not the induction of c‐fos mRNA expression is associated with differentiation of SH‐SY5Y human neuroblastoma cells
16. Calcium‐activated, phospholipid‐dependent protein kinase from rat brain
17. Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF‐H and NF‐M) and demonstrate their existence in the normal nervous system of adult rats
18. Requirements for the activation of protein kinase C: comparison of the molecular geometries of phorbol and diacylglycerol
19. Molecular analysis of protein kinase C activators and inhibitors: physiological implications
20. The role of protein kinase C in cell surface signal transduction and tumor promotion
21. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
22. The family of protein kinase C for signal transduction
23. Characterization of posttranslational processing of the mammalian high‐molecular‐weight neurofilament protein in vivo
24. The structure, expression, and properties of additional members of the protein kinase C family
25. Protein kinase Cζ subspecies from rat brain: its structure, expression, and properties
26. A phorbol ester receptor/protein kinase nPKCη, a new member of the protein kinase C family predominantly expressed in lung and skin
27. Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate
28. Kinetics and concentrations effects of TPA‐induced differentiation of cultured human neuroblastoma cells
29. Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function
30. Differentiation of neuroblastoma cells in culture
31. Role of phosphoinositides in transmembrane signaling
32. Expression, purification, and characterization of protein kinase C‐ε
33. Neurons switch from non‐neuronal enolase to neuron‐specific enolase during differentiation
34. Neurofilament triplet proteins of NB2a/d1 neuroblastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation
35. Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma
36. Staurosporine‐induced morphological differentiation of human neuroblastoma cells
37. Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion
38. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ
39. ++‐dependent protein kinase