The effect of aerosol distribution on airway responsiveness to inhaled methacholine in patients with asthma

The Journal of Allergy and Clinical Immunology

Volumn 89, Issue 2, 1992, Pages 510-518

  Laube, Beth L ^a   Norman, Philip S ^b   Adams III, G K ^b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aerosol distribution; airway reactivity; asthma; methacholine

Indexed keywords

METHACHOLINE; METHACHOLINE CHLORIDE;

ADULT; AEROSOL; AIRWAY CONDUCTANCE; ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INSPIRATORY CAPACITY; MALE; PHARMACOKINETICS; PRIORITY JOURNAL; PROVOCATION TEST; SCINTILLATION CAMERA;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; ASTHMA; ASTHMA, EXERCISE-INDUCED; FEMALE; FORCED EXPIRATORY VOLUME; GAMMA CAMERAS; HUMAN; LUNG; MALE; METHACHOLINE CHLORIDE; PARTICLE SIZE; SUPPORT, U.S. GOV'T, P.H.S.; TECHNETIUM TC 99M SULFUR COLLOID; VITAL CAPACITY;

EID: 0026504897     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-6749(92)90317-U     Document Type: Article

References (20)

1. The effect of bronchial obstruction on central airway deposition of a saline aerosol in patients with asthma
2. Aerosol penetrance: a sensitive index of peripheral airway obstruction
3. The regional deposition of inhaled aerosols in man
4. Particle penetration and clearance in the human lung
5. Influence of airway calibre on the interpulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects
6. Radionuclide demonstration of ventilatory abnormalities in mild asthma
7. Simplified assessment of fine aerosol distribution in human airways
8. Production and characterization of aerosols
9. Single-breath deposition of jet-nebulized saline aerosol
10. Absolute quantitation of radiotracer uptake in the lungs and using a gamma camera
11. Characteristics of nebulizers used in the treatment of AIDS-related pneumocystis carinii pneumonia
12. Effect of breathing pattern during inhalation challenge on the shape and position of the dose-response curve in normal and asthmatic subjects
13. Inhalation patterns and predominant site of bronchoconstriction in healthy subjects
14. The effects of preferential deposition of histamine in the human airway
15. Standardization of bronchial inhalation challenge procedures
16. Relationship between deposition of and responsiveness to inhaled methacholine in normal and asymptomatic subjects
17. Variability of airway responsiveness to histamine aerosol in normal subjects
18. The influence of aerosol retention and pattern of deposition on bronchial responsiveness to atropine and methacholine in humans
19. Ventilation scanning with technetium-labelled aerosols: DTPA or sulfur colloid