Synthesis of carboranes containing nucleoside bases. Unexpectedly high cytostatic and cytocidal toxicity towards cancer cells

Journal of the Chemical Society, Chemical Communications

Volumn , Issue 2, 1992, Pages 157-158

  Yamamoto, Yoshinori ^a   Seko, Toshiya ^a   Nakamura, Hiroyuki ^a   Nemoto, Hisao ^a   Hojo, Hiroshi ^a   Mukai, Naoto ^a   Hashmioto, Yosiyuki ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBORANE DERIVATIVE; NUCLEOSIDE DERIVATIVE;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL GROWTH; CELL KINETICS; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG SYNTHESIS; GROWTH INHIBITION; LEUKEMIA P 388; MOUSE; NONHUMAN; TUMOR CELL LINE;

EID: 0026501031     PISSN: 00224936     EISSN: None     Source Type: Journal    
DOI: 10.1039/C39920000157     Document Type: Article

References (8)

1. A.K.M. Anisuzzaman, F. Alam and A.H. Soloway, Polyhedron, 9, 891, For nucleoside bases containing boronic acid.
2. R.F. Schinazi and W.H. Prusoff, J. Org. Chem., 50, 841.
3. Y. Yamamoto, T. Seko, F.G. Rong and H. Nemoto, Tetrahedron Lett., 30, 7191.
4. Y. Yamamoto, Pure Appl. Chem., 63, 423.
5. M.J. Robins, P.J. Barr and J. Giziewiciz, Can J. Chem., 60, 554.
6. T.L. Heying, J.W. AgerJr., S.L. Clark, D.J. Mangold, H.L. Goldstein, M. Hillman, R.J. Polak and J.W. Szymanski, Inorg. Chem., 2, 1089, It is well known that the reaction of alkynes with decaborane gives 1, 2-dicarba-closo-dodecaborane.
7. M.M. Flein, J. Bobinski, N. Maves, N. Schwartz and M. Cohen, Inorg. Chem., 2, 1111, However, this procedure has not been used for the preparation of carboranes bonded to nucleoside bases. For another synthesis see ref. 1 (a).
8. C. Heidelberger, N.K. Chaudhuri, P. Danneberg, D. Mooren, L. Griesbach, R. Duschinsky, R.J. Schinitzer, E. Pleven and J. Scheiner, Nature, 179, 663.