Development of a Novel Class of Cyclic Hexapeptide Oxytocin Antagonists Based on a Natural Product

Journal of Medicinal Chemistry

Volumn 35, Issue 21, 1992, Pages 3905-3918

  Williams, Peter D ^a   Bock, Mark G ^a   Tung, Roger D ^a   Garsky, Victor M ^a   Perlow, Debra S ^a   Erb, Jill M ^a   Lundell, G F ^a   Gould, Norman P ^a   Whitter, Willie L ^a   Hoffman, James B ^a   Kaufman, Michael J ^a,b   Clineschmidt, Bradley V ^a,b   Pettibone, Douglas J ^a,b   Freidinger, Roger M ^a   Veber, Daniel F ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Department of Pharmaceutical Research and Development ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ RECEPTOR; L 365209; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; VASOPRESSIN V2 RECEPTOR;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; MALE; MONKEY; MOUSE; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; UTERUS CONTRACTION;

AMINO ACID SEQUENCE; ANIMAL; FEMALE; HAPLORHINI; IN VITRO; MALE; MOLECULAR SEQUENCE DATA; OXYTOCIN; PEPTIDES, CYCLIC; RADIOLIGAND ASSAY; RATS; RECEPTORS, ANGIOTENSIN; RECEPTORS, OXYTOCIN; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0026498297     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00099a019     Document Type: Article

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