Excitotoxic cell death

Journal of Neurobiology

Volumn 23, Issue 9, 1992, Pages 1261-1276

  Choi, Dennis W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA; calcium; cell culture; cortex; excitotoxicity; glutamate; kainate; N methyl D aspartate

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CALCIUM ION; EXCITATORY AMINO ACID; EXCITATORY AMINO ACID RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

BRAIN INJURY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; HIPPOCAMPUS; NERVE CELL NECROSIS; NEUROTRANSMITTER RELEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SPINAL CORD INJURY; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMAL; CALCIUM; CELL DEATH; GLUTAMATES; GLUTAMIC ACID; HUMAN; MODELS, NEUROLOGICAL; NEURONS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026497926     PISSN: 00223034     EISSN: 10974695     Source Type: Journal    
DOI: 10.1002/neu.480230915     Document Type: Article

References (116)

1. 2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cultures
2. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells
3. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
4. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
5. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy
6. Influence of cortio‐striatal afferents on striatal kainic acid neurotoxicity
7. Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation
8. Nitric oxide, a novel neuronal messenger
9. Calcium‐permeable AMPA‐kainate receptors in fusiform cerebellar glial cells
10. Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury
11. Glutamate neurotoxicity in cortical cell culture is calcium dependent
12. Ionic dependence of glutamate neurotoxicity in cortical cell culture
13. Glutamate neurotoxicity in cortical cell culture
14. Calcium‐mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
15. Glutamate neurotoxicity and diseases of the nervous system
16. Excitotoxicity
17. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists
18. Methods for antagonizing glutamate neurotoxicity
19. Group report: neuronal death and survival
20. Developmental cell death: morphological diversity and multiple mechanisms
21. 2+ induced by excitatory amino acids in CA1 hippocampal neurons
22. Anatomical organization of excitatory amino acid receptors and their pathways
23. Excitatory amino acid neurotoxins: selectively and mechanisms of action
24. Neurotoxic action of kainic acid
25. Amino acid transmitters in the mammalian central nervous system
26. No evidence of preservation of somatostatin‐containing neurons after intrastriatal injections of quinolinic acid
27. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
28. New wave of non‐NMDA excitatory amino acid receptors
29. Endogenous endonuclease‐induced DNA fragmentation: an early event in cell‐mediated cytolysis
30. NMDA receptors activate the arachidonic acid cascade system in striatal neurons
31. Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury
32. Mechanisms and functions of cell death
33. Calcium dependency of N‐methyl‐d‐aspartate toxicity in slices from the immature rat hippocampus
34. Direct evidence that excitotoxicity in cultured neurons is mediated via N‐methyl‐d‐aspartate (NMDA). as well as non‐NMDA receptors
35. 2+ release from intracellular stores in cultured cerebral cortical neurons
36. Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration
37. Amino acid neurotoxicity: intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro
38. Endothelium‐derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
39. Substantia nigra lesion protects against ischemic damage in the striatum
40. 2+: toxicity is blocked by the N‐methyl‐d‐aspartate antagonist MK‐801
41. Delayed rescue of N‐methyl‐d‐aspartate receptor‐mediated neuronal injury in cortical culture
42. Selective destruction of neurons by a transmitter agonist
43. A unique glutamate binding site in an autoradiographic assay
44. 2+ dependence
45. Implications of nematode neuronal cell death for human neurological disorders
46. The glutamate analogue alpha‐aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro
47. Identification of a site in glutamate receptor subunits that controls calcium permeability
48. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones
49. Dose‐dependent effects of intravitreal kainic acid on specific cell types in chicken retina
50. L‐Homocysteate is a potent neurotoxin on cultured cortical neurons
51. Neurons containing NADPH‐diaphorase are selectively resistant to quinolinate toxicity
52. Non‐NMDA receptor‐mediated neurotoxicity in cortical culture
53. Selective blockade of non‐NMDA receptors does not block rapidly triggered glutamate‐induced neuronal death
54. Activation of the metabotropic glutamate receptor attenuates N‐methyl‐d‐aspartate neurotoxicity in cortical cultures
55. Comparison of ibotenate and kainate neurotoxicity in rat brain: a histological study
56. Glutamate triggers internucleosomal DNA cleavage in neuronal cells
57. 45Ca influx and resultant neuronal injury in cultured cortical neurons
58. Calciummediated myopathy at neuromuscular junctions of normal and dystrophic muscle
59. NMDA‐receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
60. 2+ influx elicited by glutamate: role in neuronal death
61. Nitric oxide‐induced blockage of NMDA receptors
62. Ketamine prevents glutamate‐induced calcium influx and ischemia nerve cell injury
63. Sequence and expression of a metabotropic glutamate receptor
64. Intracellular messengers in the generation and degeneration of hippocampal neuroarchitecture
65. Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture
66. Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture
67. 51chromium
68. Duplication of biochemical changes of Huntingdon's chorea by intrastriatal injections of glutamic and kainic acids
69. Kainic acid: the neurotoxic breakthrough
70. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters
71. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations
72. Potentiation of NMDA receptor currents by arachidonic acid
73. 21‐Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures
74. Heteromeric NMDA Receptors: molecular and functional distinction of subtypes
75. Molecular cloning and characterization of the rat NMDA receptor (see comments)
76. Possible role of carbamates in neurotoxicity and neurotransmitter inactivation
77. Quisqualate‐induced changes in extracellular sodium and calcium concentrations persist in the combined presence of NMDA and non‐NMDA receptor antagonists in rat hippocampal slices
78. Calcium entry through kainate receptors and resulting potassiumchannel blockade in Bergmann glial cells
79. The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro
80. Calcium‐dependent glutamate cytotoxicity in a neuronal cell line
81. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
82. The activation of inositol phospholipid metabolism as a signaltransducing system for excitatory amino acids in primary cultures of cerebellar granule cells
83. 2+‐Activated mechanisms in cell killing
84. 2+ after exposure to glutamate receptor agonist
85. Brain lesion, obesity and other disturbances in mice treated with monosodium glutamate
86. Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system
87. Glutamate‐induced brain damage in infant primates
88. Kainic acid: a powerful neurotoxic analogue of glutamate
89. Stereospecificity of the gliotoxic and antineurotoxic actions of alpha‐aminoadipate
90. Inciting excitotoxic cytocide among central neurons
91. The role of specific ions in glutamate neurotoxicity
92. L‐cysteine, a bicarbonate‐sensitive endogenous excitotoxin
93. 2+‐Mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine
94. Excitatory amino acid release form rat hippocampal slices as a consequence of free‐radical formation
95. Glutamateinduced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
96. Nordihydroguaiaretic acid (NDGA). attenuates slow excitatory amino acid‐induced neuronal degeneration in cortical cultures
97. Nitric oxide synthase activation, or cystine depletion, may not be critical to NMDA receptor‐mediated injury in murine cortical cultures
98. The neurotoxicity of excitatory amino acids is produced by passive chloride influx
99. Excitotoxicity and the NMDA receptor
100. Delayed neurotoxicity of excitatory amino acids in vitro
101. Kainic acid: neurotoxic effects intraocular injection
102. Free radicals and brain damage
103. Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage
104. Glutamate stimulates inositol phosphate formation in striatal neurones
105. Calcium‐binding protein (calbindin‐D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizu
106. A family of metabotropic glutamate receptors
107. Structural determinants of ion flow through recombinant glutamate receptor channels
108. The rod bipolar cell of the mammalian retina
109. Agonists and antagonists for excitatory amino acid receptors
110. Structure‐activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists
111. Neurotoxicity of beta‐N‐methylamino‐l‐anine (BMAA) and beta‐N‐oxalylamino‐l‐alanine (BOAA). on cultured cortical neurons
112. Nifedipine attenuates slow excitatory amino acid neurotoxicity
113. Cortical neurons containing somatostatin or parvalbumin‐like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro
114. 2+ dependent
115. Arachidonic acid induces a longterm activity‐dependent enhancement of synaptic transmission in the hippocampus
116. Cell death: the significance of apoptosis