The effects of the nitric oxide donors molsidomine and SIN-1 on human polymorphonuclear leucocyte function in vitro and ex vivo

European Journal of Clinical Pharmacology

Volumn 43, Issue 6, 1992, Pages 629-633

  Darius, H ^a   Grodzinska, L ^b   Meyer, J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Copernicus Medical Academy ^*  (Poland)

Author keywords

Aglucuronidase, superoxide anions; Molsidomine, SIN I, Neutrophil leucocytes

Indexed keywords

BETA GLUCURONIDASE; LINSIDOMINE; MOLSIDOMINE; PLACEBO; SUPEROXIDE;

ADULT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NEUTROPHIL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADULT; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; GLUCURONIDASE; HUMAN; MALE; MOLSIDOMINE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; SUPEROXIDES; VASODILATOR AGENTS;

EID: 0026495904     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/BF02284962     Document Type: Article

References (17)

1. Wirksamer Metabolit von Molsidomin und Stimulation der cGMP Bildung durch Sydnonimine
2. Release of plasminogen activator by molsidomine and its metabolite SIN-I
3. Effect of molsidomine on t-PA and PAI activity in man: a double blind, placebo controlled study
4. The effects of molsidomine and its metabolite SIN-1 on coronary vessel tone, platelet aggregation and eicosanoid formation in vitro- inhibition of 12-HPETE biosynthesis
5. Reduction of occlusive coronary artery thrombosis and myocardial ischemia by molsidomine in anesthetized dogs
6. Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes
7. Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP
8. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog
9. Neutrophils as potential participants in acute myocardial ischaemia: relevence to perfusion
10. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs
11. Wirkung von Molsidomin auf die fibrinolytische Aktivität: Eine doppelblinde, randomisierte Studie
12. Comparison of anti-platelet properties of molsidomine, isosorbide-5-mononitrate and placebo in healthy volunteers
13. Wirkung von Molsidomin auf die Thrombozytenfunktion und das Prostaglandinsystem
14. Mechanism of vasodilation by molsidomine
15. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase
16. Molecular aspects underlying the vasodilator action of molsidomine