Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

Hepatology

Volumn 16, Issue 6, 1992, Pages 1423-1427

  Hirano, Akeshi ^a   Kaplowitz, Neil ^a   Tsukamoto, Hidekazu ^b   Kamimura, Seiichiro ^b   Fernandez‐Checa, Jose C ^a,c,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

^c Hospital Clinic   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; MALONALDEHYDE;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; EXPERIMENTAL MODEL; FATTY LIVER; GLUTATHIONE METABOLISM; LIPID PEROXIDATION; LIVER INJURY; LIVER MITOCHONDRION; LIVER NECROSIS; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT; THEORY;

ALANINE TRANSAMINASE; ANIMAL; CYTOSOL; GLUTATHIONE; KIDNEY; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MALONDIALDEHYDE; MITOCHONDRIA; MITOCHONDRIA, LIVER; ORGAN WEIGHT; RATS; RATS, WISTAR; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026493715     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.1840160619     Document Type: Article

References (32)

1. Alcoholic liver disease: pathologic, pathogenic and clinic aspects
2. Glutathione, alcohol and hepatotoxicity
3. Role of xanthine oxidase in ethanol‐induced lipid peroxidation in rats
4. Assay, purification and mechanism of action of γ‐glutamyl‐cysteine synthetase from the liver of the rat and xenopus laevis
5. High‐affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function
6. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol‐fed rats
7. Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester
8. Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects
9. Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3‐bis (2‐chloroethyl)‐1‐nitrosourea (BCNU)
10. 2+ ionophore‐induced injury to isolated hepatocytes
11. Purification and enzymatic identity of mitochondrial contraction factors I and II
12. Effects of chronic ethanol‐feeding on rat hepatocytic glutathione: compartmentation, efflux and response to incubation with ethanol
13. Effects of chronic ethanol feeding on rat hepatocytic glutathione: relationship of cytosolic glutathione to efflux and mitochondrial sequestration
14. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low‐fat diet
15. Ethanolinduced liver fibrosis in rats fed high fat diet
16. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report
17. High‐performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide and related thiols and disulfides
18. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues
19. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
20. Hepatic adenine nucleotide metabolism measured in vivo in rats fed ethanol and high fat‐low protein diet
21. 31P nuclear magnetic resonance study in rats
22. The effect of ethanol on the temperature dependence of respiration and ATPase activities of rat liver mitochondria
23. Effect of chronic ethanol intoxication on oxidative phosphorylation in rat liver submitochondrial particles
24. The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism
25. Comparison of effects of long‐term ethanol consumption on the heart and liver of the rat
26. Effects of chronic ethanol treatment upon rat liver mitochondria
27. Structural and functional effects of ethanol on hepatic mitochondria
28. Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption
29. Effects of chronic ethanol consumption on energy‐linked processes associated with oxidative phosphorylation: proton translocation and ATP‐Pi exchange
30. Control of adenine nucleotide metabolism in hepatic mitochondria from rats with ethanol‐induced fatty liver
31. Status of the mitochondrial pool of glutathione in the isolated hepatocyte
32. Intracellular catalase function: analysis of the catalytic activity by product formation in isolated liver cells