Two‐Locus models of disease

Genetic Epidemiology

Volumn 9, Issue 5, 1992, Pages 347-365

  Neuman, Rosalind J ^a   Rice, John P ^a   Chakravarti, Aravinda ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

complex trait; epistasis; heterogeneity; recurrence risk; variance components

Indexed keywords

ARTICLE; GENETIC ANALYSIS; GENETICS; HUMAN; MATHEMATICAL GENETICS; MATHEMATICAL MODEL; PREVALENCE; RISK ASSESSMENT; SCHIZOPHRENIA; STATISTICAL ANALYSIS;

BIPOLAR DISORDER; EPISTASIS, GENETIC; GENE FREQUENCY; GENETIC DISEASES, INBORN; HUMAN; MATHEMATICS; MODELS, GENETIC; PREVALENCE; RECURRENCE; RISK FACTORS; SCHIZOPHRENIA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VARIATION (GENETICS);

EID: 0026491157     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.1370090506     Document Type: Article

References (30)

1. Multifactorial models for familial diseases in man
2. Hypotheses de dimerie et de non‐penetrance
3. Family studies of schizophrenia
4. A general model for the genetic analysis of pedigree data
5. A note on the essential parameters of the two‐allele autosomal locus model
6. Linkage analysis assuming a single‐locus mode of inheritance for traits determined by two loci: Inferring mode of inheritance and estimating penetrance
7. Phenogram enumeration: The number of regular genotype‐phenotype correspondences in genetic systems
8. Frequency in relatives for an all‐or‐none trait
9. A model for the genetics of handedness
10. A genetical model for emergenesis: In memory of Laurence H. Snyder, 1901–86
11. The derivation of joint distribution and correlation between relatives by the use of stochastic matrices
12. Strategies and sample‐size considerations for mapping a two‐locus autosomal recessive disorder
13. On the genetics of prelingual deafness
14. Analysis of family resemblance. III. Complex segregation of quantitative traits
15. Complex segregation analysis
16. Genetic etiology of schizophrenia and affective disorders
17. Linkage strategies for genetically complex traits. I. Multilocus models
18. Limits of the general two‐allele single locus model with incomplete penetrance
19. A two locus model for juvenile diabetes
20. Localization of Charcot‐Marie‐Tooth disease type 1a (CMT1A) to chromosome 17p11.2
21. Linkage analysis of two‐locus diseases under single locus and two‐locus analysis models
22. Tuberous sclerosis: genetic heterogeneity with evidence for loci on chromosomes 9 and 11