Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation

Endocrine Reviews

Volumn 13, Issue 4, 1992, Pages 692-706

  Pike, Linda J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; GELSOLIN; GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL KINASE; PROFILIN; ENZYME VARIANT; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; POLYPHOSPHOINOSITIDE; RAS PROTEIN;

ACTIN POLYMERIZATION; ENZYME ACTIVITY; ENZYME REGULATION; HORMONE ACTION; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; REACTION ANALYSIS; REVIEW; SIGNAL TRANSDUCTION; CELL FUNCTION; CELL METABOLISM; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; NONHUMAN;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMAL; CELL PHYSIOLOGY; HOMEOSTASIS; HUMAN; PHOSPHATIDYLINOSITOLS; PHOSPHOTRANSFERASES; SIGNAL TRANSDUCTION;

EID: 0026474287     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-13-4-692     Document Type: Article

References (150)

1. 32 into phospholipides of pancreas slices. J Biol Chem 203:967-977
2. Hokin LE, Hokin MR 1955 Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices. Biochim Biophys Acta 18:102-110
3. Michell RH 1975 Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta 415:81-147
4. Michell RH, Kirk CJ, Jones LM, Downes CP, Creba JA 1981 The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. Philos Trans R Soc Lond [Biol] 296:123-137
5. Berridge MR, Irvine RF 1984 Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312:315-321
6. Nishizuka Y 1986 Studies and perspectives of protein kinase C. Science 233:305-312
7. Majerus PW, Ross TS, Cunningham TW, Caldwell KK, Jefferson AB, Bansal VS 1990 Recent insights in phosphatidylinositol signaling. Cell 63:459-465
8. Berridge MJ 1987 Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu Rev Biochem 56:159-193
9. Kikkawa U, Kishimoto A, Nishizuka Y 1989 The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem 58:31-44
10. Folch J 1949 Complete fractionation of brain cephalin: isolation from IT of phosphatidyl serine, phosphatidyl ethanolamine, and diphosphoinositide. J Biol Chem 177:497-504
11. Garbus J, DeLuca HF, Loomans ME, Strong FM 1963 The rapid incorporation of phosphate into mitochondrial lipids. J Biol Chem 238:59-63
12. Whitman M, Downes CP, Keeler M, Keller T, Cantley L 1988 Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644-646
13. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC 1989 PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167-175
14. Serunian LA, Auger KR, Roberts TM, Cantley LC 1990 Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen. J Virol 64:4718-4725
15. Irvine RF, Moor RM, Pollock WK, Smith PM, Wreggett KA 1988 Inositol phosphates: proliferation, metabolism and function. Philos Trans R Soc Lond [Biol] 320:281-298
16. Majerus PW 1992 Inositol phosphate biochemistry. Annu Rev Biochem 61:225-250
17. Graziani A, Ling LE, Endemann G, Carpenter CL, Cantley LC 1992 Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. Biochem J 284:39-45
18. Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC 1990 Purification and characterization of phosphoinositide 3-kinase from rat liver monomer and heterodimer form. J Biol Chem 265:19704-19711
19. Lips DL, Majerus PW, Gorga FR, Young AT, Benjamin TL 1989 Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem 264:8759-8763
20. Serunian LA, Haber MT, Fukui T, Kim JW, Rhee SG, Lowenstein JM, Cantley LC 1989 Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. J Biol Chem 264:17809-17815
21. Carpenter CL, Cantley LC 1990 Phosphoinositide kinases. Biochemistry 29:11147-11156
22. Galliard T, Hawthorne JN 1963 Rapid labelling of diphosphoinositide in liver mitochondria. Biochim Biophys Acta 70:479-481
23. Michell RH, Hawthorne JN 1965 The site of diphosphoinositide synthesis in rat liver. Biochem Biophys Res Commun 21:333-338
24. Galliard T, Michell RH, Hawthorne JN 1965 Incorporation of phosphate into diphosphoinositide by subcellular fractions from liver. Biochim Biophys Acta 106:551-563
25. Jergil G, Sundler R 1983 Phosphorylation of phosphatidylinositol in rat liver Golgi. J Biol Chem 258:7968-7973
26. Collins CA, Wells WW 1983 Identification of phosphatidylinositol kinase in rat liver lysosomal membranes. J Biol Chem 258:2130-2134
27. Smith CD, Wells WW 1983 Phosphorylation of rat liver nuclear envelopes. II. Characterization of in vitro lipid phosphorylation. J Biol Chem 258:9368-9373
28. Cockcroft S, Taylor JA, Judah JD 1985 Subcellular localization of inositol lipid kinases in rat liver. Biochim Biophys Acta 845:163-170
29. Campbell CR, Fishman JB, Fine RE 1985 Coated vesicles contain a phosphatidylinositol kinase. J Biol Chem 260:10948-10951
30. Olsson H, Persson A, Jergil B 1991 Purification of liver membranes highly enriched in phosphatidylinositol kinase. Cell Signaling 3:353-359
31. Del Vecchio RL, Pilch PF 1991 Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles. J Biol Chem 266:13278-13283
32. Kanoh H, Banno Y, Hirata M, Nozawa Y 1990 Partial purification and characterization of phosphatidylinositol kinases from human platelets. Biochim Biophys Acta 1046:120-126
33. Harwood JL, Hawthorne JN 1969 The properties and subcellular distribution of phosphatidylinositol kinase in mammalian tissues. Biochim Biophys Acta 171: 75-88
34. Whitman M, Kaplan D, Roberts T, Cantley L 1987 Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Biochem J 247:165-174
35. Endemann G, Dunn SN, Cantley LC 1987 Bovine brain contains two types of phosphatidylinositol kinase. Biochemistry 26:68456852
36. Auger KR, Carpenter CL, Cantley LC, Varticovski L 1989 Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. J Biol Chem 264:20181-20184
37. Buxeda RJ, Nickels Jr JT, Belunis CJ, Carman GM 1991 Phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Kinetic analysis using Triton X-100/phosphatidylinositol-mixed micelles. J Biol Chem 266:13859-13865
38. Morgan SJ, Smith AD, Parker PJ 1990 Purification and characterization of bovine brain type I phosphatidylinositol kinase. Eur J Biochem 191:761-767
39. Shibasaki F, Homma Y, Takenawa T 1991 Two types of phosphatidylinositol 3-kinase from bovine thymus. J Biol Chem 266:8108-8114
40. Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT 1991 cDNA Cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3kinase to the PDGF /3-receptor. Cell 65:775-82
41. Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM 1985 Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 315:239-242
42. Macara IG, Marinetti GV, Balduzzi PC 1984 Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis. Proc Natl Acad Sci USA 81:2728-2732
43. Sugimoto Y, Whitman M, Cantley LC, Erikson RL 1984 Evidence that the rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci USA 81:2117-2121
44. Fukui Y, Kornbluth S, Jong SM, Wang LH, Hanafusa H 1989 Phosphatidylinositol kinase type I activity associates with various oncogene products. Oncogene Res 4:283-292
45. fyn in human platelets. Mol Cell Biol 10:3806-3809
46. Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM 1987 Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021-1029
47. 8rc: a possible phosphatidylinositol kinase. Cell 50:1031-1037
48. MacDonald ML, Kuenzel EA, Glomset JA, Krebs EG 1985 Evidence from two transformed cell lines that the phosphorylations of peptide tyrosine and phosphatidylinositol are catalyzed by different proteins. Proc Natl Acad Sci USA 82:3993-3997
49. Coughlin SR, Escobedo JA, Williams LT 1989 Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science 243:1191-1194
50. Kazlauskas A, Cooper JA 1990 Phosphorylation of the PDGF receptor subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J 9:3279-3286
51. Varticovski L, Druker B, Morrison D, Cantley L, Roberts T 1989 The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature 342:699-702
52. Bjorge JD, Chan TO, Antczak M, Kung H-J, Fujita DJ 1990 Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation. Proc Natl Acad Sci USA 87:3816-3820
53. Lev S, Givol D, Yarden Y 1991 A specific combination of substrates is involved in signal transduction by the kit-encoded receptor. EMBO J 10:647-654
54. Yonezawa K, Yokono K, Shii K, Ogawa W, Ando A, Hara K, Baba S, Kaburagi Y, Yamamoto-Honda R, Momomura K, Kadowaki T, Kasuga M 1992 In vitro association of phosphatidylinositol 3-kinase activity with the activated insulin receptor tyrosine kinase. J Biol Chem 267:440-446
55. Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J 1991 Cloning of PI3 kinaseassociated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83-90
56. Koch CA, Anderson D, Moran MF, Ellis C, Pawson T 1991 SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 25:668-674
57. McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu G, Reith AD, Panayotou G, End P, Bernstein A, Kazlauskas A, Waterfield MD, Pawson T 1992 SH2 domains of the p85 a subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol 12:991-997
58. 8rc Mol Cell Biol 11:1972-1979
59. Escobedo JA, Williams LT 1988 A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF. Nature 335:85-87
60. Kazlauskas A, Cooper JA 1989 Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell 58:1121-1133
61. Lehto VP, Wasenius VM, Salven P, Saraste M 1988 Transforming and membrane proteins. Nature 334:388
62. Rodaway ARF, Sternberg MJE, Bentley DL 1989 Similarity in membrane proteins. Nature 342:624
63. Drubin DG, Mulholland J, Zhu Z, Botstein D 1990 Homology of a yeast actin-binding protein to signal transduction proteins and myosin-1. Nature 343:288-290
64. Li YS, Porter FD, Hoffman RM, Deuel TF 1989 Separation and identification of two phosphatidylinositol 4-kinase activities in bovine uterus. Biochem Biophys Res Commun 160:202-209
65. Yamakawa A, Takenawa T1988 Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain. J Biol Chem 263:17555-17560
66. Thompson DM, Verma B, Thomas C 1988 Partial purification and characterization of phosphatidylinositol kinase from bovine brain. Neurochem Res 13:417-421
67. Yamakawa A, Nishizawa M, Fujiwara KT, Kawai S, Kawasaki H, Suzuki K, Takenawa T 1991 Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain. J Biol Chem 266:17580-17583
68. Suzuki H, Kawarabayasi Y, Kondo J, Abe T, Nishikawa K, Kimura S, Hashimoto T, Yamamoto T 1990 Structure and regulation of rat long-chain acyl-CoA synthetase. J Biol Chem 265:8681-8685
69. Walker DH, Dougherty N, Pike LJ 1988 Purification and characterization of a phosphatidylinositol kinase from A431 cells. Biochemistry 27:6504-6511
70. Porter FD, Li Y-S, Deuel TF 1988 Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri. J Biol Chem 263:8989-8995
71. Hou W-M, Zhang Z-L, Tai H-H 1988 Purification and characterization of phosphatidylinositol kinase from porcine liver microsomes. Biochim Biophys Acta 959:67-75
72. Scholz G, Barritt GJ, Kwok F 1991 Purification and chemical modification of a phosphatidylinositol kinase from sheep brain. Eur J Biochem 201:249-255
73. Jenkins GH, Subrahmanyam G, Anderson RA 1991 Purification and reconstitution of phosphatidylinositol 4-kinase from human erythrocytes. Biochim Biophys Acta 1080:11-18
74. Saltiel AR, Fox JA, Sherline P, Sahyoun N, Cuatrecasas P 1987 Purification of phosphatidylinositol kinase from bovine brain myelin. Biochem J 241:759-763
75. Wetzker R, Klinger R, Hsuan J, Fry MJ, Kauffmann-Zeh A, Muller E, Frunder H, Waterfield M 1991 Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes. Eur J Biochem 200:179-185
76. Belunis CJ, Bae-Lee M, Kelley MJ, Carman GM 1988 Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae. J Biol Chem 263:18897-18903
77. Young RC, Downes CP, Eggleston DS, Jones M, Macphee CH, Rana KK, Ward JG1990 Total synthesis of the four stereoisomers of dihexadecanoyl phosphatidylinositol and the substrate stereospecificity of human erythrocyte membrane phosphatidylinositol 4-kinase. J Med Chem 33:641-646
78. Young RC, Jones M, Milliner KJ, Rana KK, Ward JG 1990 Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. J Med Chem 33:20732080
79. Naito T, Nakagawa S, Okita TA, Yamashita H, Yamasaki T, Kamei H, Tomatsu K, Imanishi H, Kawaguchi H 1982 Synthesis and bronchodilating activity of 2, 9-disubstituted adenine derivaties: BB-1502 (9-cyclohexyl-2-n-propoxy-9 H-adenine) and its analogs. Chem Pharm Bull (Tokyo) 30:2011-2019
80. Nishioka H, Imoto M, Sawa T, Hamada M, Naganawa H, Takeuchi T, Umezawa K 1989 Screening of phosphatidylinositol kinase inhibitors from Streptomyces. J Antibiotics 42:823-825
81. Vogel S, Hoppe J 1986 Polyamines stimulate the phosphorylation of phosphatidylinositol in membranes from A431 cells. Eur J Biochem 154:253-257
82. Smith CD, Snyderman R 1988 Modulation of inositol phospholipid metabolism by polyamines. Biochem J 256:125-130
83. Lundberg GA, Sundler R, Jergil B 1987 Activation of phosphatidylinositol-4-phosphate kinase in rat liver plasma membranes by polyamines. Biochim Biophys Acta 922:1-7
84. Husebye ES, Fiatmark T 1988 Phosphatidylinositol kinase of bovine adrenal chromaffin granules. Biochem Pharmacol 37:4149-4156
85. Gatica M, Allende CC, Antonelli M, Allende JE 1987 Polylysinecontaining peptides, including the carboxyl-terminal segment of the human c-Ki-ras 2 protein, affect the activity of some key membrane enzymes. Proc Natl Acad Sci USA 84:324-328
86. Lo TN, Eng SP, Jaseph LA, Beaven MA, Lo CS 1988 Cardiotoxin from cobra venom increases the level of phosphatidylinositol 4monophosphate and phosphatidylinositol kinase activity in two cell lines. Biochim Biophys Acta 970:51-60
87. Walker DH, Pike LJ 1990 Stimulation of purified phosphatidylinositol 4-kinase by cobra venom cardiotoxin. Biochim Biophys Acta 1055:295-298
88. Eng SP, Lo CS 1990 Mastoparan increases membrane bound phosphatidylinositol kinase and phosphatidylinositol 4-monophosphate kinase activities in Madin-Darby canine kidney cells. Life Sci 46:273-279
89. Higashijima T, Uzu S, Nakajima T, Ross EM 1988 Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). J Biol Chem 263:6491-6494
90. Taylor MV, Metcalfe JC, Hesketh TR, Smith GA, Moore JP 1984 Mitogens increase phosphorylation of phosphoinositides in thymocytes. Nature 312:462-465
91. Pike LJ, Eakes AT 1987 Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A 431 cells. J Biol Chem 262:1644-1651
92. Walker DH, Pike LJ 1987 Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor. Proc Natl Acad Sci USA 84:7513-7517
93. Ballou LR, Barker SC, Postlethwaite AE, Kang AH 1991 Interleukin 1 stimulates phosphatidylinositol kinase activity in human fibroblasts. J Clin Invest 87:299-304
94. Thompson DM, Cochet C, Chambaz EM, Gill GN 1985 Separation and characterization of a phosphatidylinositol kinase activity that co-purifies with the epidermal growth factor receptor. J Biol Chem 260:8824-8830
95. Cochet C, Filhol O, Payrastre B, Hunter T, Gill GN 1991 Interaction between the epidermal growth factor receptor and phosphoinositide kinases. J Biol Chem 266:637-644
96. HER2 Signal transduction in breast cancer cells. J Biol Chem 266:14300-14305
97. Chen Y, Yang D-C, Brown AB, Jeng Y, Tatoyan A, Chan TM 1990 Activation of a membrane-associated phosphatidylinositol kinase through tyrosine-protein phosphorylation by naphthoquinones and orthovanadate. Arch Biochem Biophys 283:184-192
98. Gaudette DC, Holub BJ 1990 Effect of genistein, a tyrosine kinase inhibitor, on U46619-induced phosphoinositide phosphorylation in human platelets. Biochem Biophys Res Commun 170:238-242
99. de Chaffoy de Courcelles D, Roevens P, van Belle H, 1986 Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets. FEBS Lett 195:115-118
100. Kato H, Uno I, Ishikawa T, Takenawa T 1989 Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cereuisiae. J Biol Chem 264:3116-3121
101. Bianca VD, De Togni P, Grzeskowiak M, Vicentini LM, De Virgilio F 1986 Cyclic AMP inhibition of phosphoinositide turnover in human neutrophils. Biochim Biophys Acta 886:441-447
102. Holland KM, Homann MJ, Belunis CJ, Carman GM 1988 Regulation of phosphatidylinositol kinase activity in Saccharomyces cereuisiae. J Bacteriol 170:828-833
103. O’Shea J J, Suarez-Quian CA, Swank RA, Klausner RD 1987 The inhibitory effect of cyclic AMP on phosphatidylinositol kinase is not mediated by the cAMP dependent protein kinase. Biochem Biophys Res Commun 146:561-567
104. Giraud F, Gascard P, Sulpice JC 1988 Stimulation of polyphosphoinositide turnover upon activation of protein kinases in human erythrocytes. Biochim Biophys Acta 968:367-378
105. Halenda SP, Feinstein MB 1984 Phorbol myristate acetate stimulates formation of phosphatidylinositol 4-phosphate and phosphatidylinositol 4, 5-bisphosphate in human platelets. Biochem Biophys Res Commun 124:507-513
106. Chinkers M, McKanna JA, Cohen S 1979 Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factor. J Cell Biol 83:260-265
107. Pollard TD 1986 Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu Rev Biochem 55:987-1035
108. Lind SE, Janmey PA, Chaponnier C, Herbert T-J, Stossel TP 1987 Reversible binding of actin to gelsolin and profilin in human platelet extracts. J Cell Biol 105:833-842
109. Chaponnier C, Yin HL, Stossel TP 1987 Reversibility of gelsolin/actin interaction in macrophaages. J Exp Med 165:97-106
110. Janmey PA, Iida K, Yin HL, Stossel TP 1987 Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J Biol Chem 262:12228-12236
111. Jamney PA, Stossel TP 1989 Gelsolin-polyphosphoinositide interaction. Full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicular form and inactivation by dilution, aggregation, or masking of the inositol head group. J Biol Chem 264:4825-4831
112. Janmey PA, Stossel TP 1987 Modulation of gelsolin function by phosphatidylinositol 4, 5-bisphosphate. Nature 325:362-364
113. Hartwig JH, Chambers KA, Stossel TP 1989 Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol 108:467-479
114. Stossel TP 1989 From sigmal to pseudopod: how cells control cytoplasmic actin assembly. J Biol Chem 264:18261-18264
115. Bengtsson T, Rundquist I, Stendahl O, Wymann MP, Anderson T 1988 Increased breakdown of phosphatidylinositol 4, 5-bisphosphate is not an initiating factor for actin assembly in human neutrophils. J Biol Chem 263:17385-17389
116. Dadabay CY, Patton E, Cooper JA, Pike LJ 1991 Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor. J Cell Biol 112:1151-1156
117. Yamamoto K, Grazziani A, Carpenter C, Cantley LC, Lapetina EG 1990 A novel pathway for the formation of phosphatidylinositol 3, 4-bisphosphate. J Biol Chem 265:22086-22089
118. 7S. J Biol Chem 265:5345-5348
119. Cunningham TW, Lips DL, Bansal VS, Caldwell KK, Mitchell CA, Majerus PW 1990 Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets. J Biol Chem 265:21676-21683
120. Sultan C, Breton M, Mauco G, Grondin P, Plantavid M, Chap H 1990 The novel inositol lipid phosphatidylinositol 3, 4-bisphosphate is produced by human blood platelets upon thrombin stimulation. Biochem J 269:831-834
121. Nolan RD, Lapetina EG 1990 Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem 265:2441-2445
122. Traynor-Kaplan AE, Harris AL, Thompson BL, Taylor P, Sklar LA 1988 An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 334:353-356
123. Eberle M, Traynor-Kaplan AE, Sklar LA, Norgauer J 1990 Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils? J Biol Chem 265:16725-16728
124. Lassing I, Lindberg U 1985 Specific interaction between phosphatidylinositol 4, 5-bisphosphate and profilaction. Nature 314:472474
125. Southwick FS, Young CL 1990 The actin released from profilinactin complexes is insufficient to account for the increase in Factin in chemoattractant-stimulated polymorphonuclear leukocytes. J Cell Biol 110:1965-1973
126. 2 and inhibits its hydrolysis by phospholipase C. Science 247:1575-1578
127. 71 by profilin and tyrosine phosphorylation. Science 251:1231-1233
128. Wahl MI, Daniel TO, Carpenter G 1988 Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A431 cells. Science 241:968-970
129. Nishibe S, Wahl MI, Rhee SG, Carpenter G 1989 Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. J Biol Chem 264:10335-10338
130. Meisenhelder J, Suh PG, Rhee SG, Hunter T 1989 Phospholipase C-7 is a substrate for the PDGF and EGF receptor proteintyrosine kinases in vivo and in vitro. Cell 57:1109-1122
131. Yonezawa N, Nishida E, Iida K, Yahara I, Sakai H 1990 Inhibition of the interaction of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides. J Biol Chem 265:8382-8386
132. Yu F-X, Johnston PA, Sudhof TC, Yin HL 1990 gCAP39, a calcium ionand polyphosphoinositide-regulated actin capping protein. Science 250:1413-1415
133. Heiss SG, Cooper JA 1991 Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids. Biochemistry 30:8753-8758
134. Anderson RA, Marchesi VT 1985 Regulation of the association of membrane skeletal protein 4.1 with glycophorin by a polyphosphoinositide. Nature 318:295-298
135. Adashi EY, Resnick CE, Vera A, Hernandez E 1991 In vivo regulation of granulosa cell type I insulin-like growth factor receptors: evidence for an inhibitory role for the putative endogenous ligand(s) of the ovarian gonadotropin-releasing hormone receptor. Endocrinology 128:3130
136. Varmus HE 1984 The molecular genetics of cellular oncogenes. Annu Rev Genet 18:553-612
137. McCormick F 1989 ras GTPase activating protein: signal transmitter and signal terminator. Cell 56:5-8
138. Yu CL, Tsai MH, Stacey DW 1990 Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPaseactivating protein activity. Mol Cell Biol 10:6683-6689
139. Tsai MH, Yu CL, Wei FS, Stacey DW 1988 The effect of GTPase activating protein upon Ras is inhibited by mitogenically responsive lipids. Science 243: 522-526
140. Tsai MH, Yu CL, Stacey DW 1990 A cytoplasmic protein inhibits the GTPase activity of H-Ras in a phospholipid-dependent manner. Science 250:982-985
141. Bollag G, McCormick F 1991 Differential regulation of rasGAP and neurofibromatosis gene product activities. Nature 351:576579
142. Tsai MH, Hall A, Stacey DW 1989 Inhibition by phospholipids of the interaction between R-ras, Rho, and their GTPase-activating proteins. Mol Cell Biol 9:5260-5264
143. Golubic M, Tanaka K, Dobrowolski S, Wood D, Tsai MH, Marshall M, Tamanoi F, Stacey DW 1991 The GTPase stimulatory activities of the neurofibromatosis type I and the yeast IRA2 proteins are inhibited by arachidonic acid. EMBO J 10:2897-2903
144. Tsai MH, Roudebush M, Dobrowolski S, Yu CL, Gibbs JB, Stacey DW 1991 Ras GTPase-activating protein physically associates with mitogenically active phospholipids. Mol Cell Biol 11:27852793
145. Serth J, Lautwein A, Freeh M, Wittinghofer A, Pingoud A 1991 The inhibition of the GTPase activating protein: Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures. EMBO J 10:1325-1330
146. O’Brian CA, Arthur WL, Weinstein IB 1987 The activation of protein kinase C by the polyphosphoinositides phosphatidylinositol 4, 5-diphosphate and phosphatidylinositol 4-monophosphate. FEBS Lett 214:339-342
147. Chauhan A, Chauhan VPS, Deshmukh DS, Brockerhoff H 1989 Phosphatidylinositol 4, 5-bisphosphate competitively inhibits phorbol ester binding to protein kinase C. Biochemistry 28:49524956
148. Bazenet CE, Brockman JL, Lewis D, Chan C, Anderson RA 1990 Erythroid membrane-bound protein kinase binds to a membrane component and is regulated by phosphatidylinositol 4, 5-bisphosphate. J Biol Chem 265:7369-7376
149. Brockman JL, Anderson RA 1991 Casein kinase I is regulated by phosphatidylinositol 4, 5-bisphosphate in native membranes. J Biol Chem 266:2508-2512
150. 2+. J Biol Chem 264:1062-1067