-
8
-
-
0025963549
-
Localization of Paxillin, a Focal Adhesion Protein, to Smooth Muscle Dense Plaques, and the Myotendinous and Neuromuscular Junctions of Skeletal Muscle
-
(1991)
Exp Cell Res
, vol.192
, pp. 651-655
-
-
Turner1
Kramarcy2
Sealock3
Burridge4
-
9
-
-
0025853849
-
Cellular Invasion into Matrix Beads: Localization of β1 Integrins and Fibronectin to the Invadopodia
-
of special interest, This paper describes the use of fibronectin-coated crosslinked gelatin beads to examine the contribution of β1 integrins and fibronectin to cell invasiveness. In transformed cells, invading fibronectin-coated matrix beads, β1 integrins and fibronectin were involved in the extension of invadopodia.
-
(1991)
J Cell Sci
, vol.99
, pp. 213-225
-
-
Mueller1
Chen2
-
10
-
-
0025359581
-
Regulation of Proteolysis at the Neutrophil-Substrate Interface by Secretory Leukoprotease Inhibitor
-
(1990)
Science
, vol.249
, pp. 178-181
-
-
Rice1
Weiss2
-
11
-
-
0025744525
-
Clear Zone in Osteoclast Function: Role of Podosomes in Regulation of Bone-resorbing Activity
-
of special interest, The adhesion and resorption of bone matrix by osteoclasts occur at podosomes and ruffled border membranes, respectively. The podosome-sealing membrane surrounds the ruffled border and seals the resorption compartment, in which bone resorption takes place.
-
(1991)
Am J Physiol
, vol.261
, pp. C1-C7
-
-
Teti1
Marchision2
Zallone3
-
12
-
-
0025809874
-
Inhibition of Autoproteolytic Activation of Interstitial Procollagenase by Recombinant Metalloproteinase Inhibitor MI/TIMP-2
-
(1991)
J Biol Chem
, vol.266
, pp. 3893-3899
-
-
Declerck1
Yean2
Lu3
Ting4
Langley5
-
13
-
-
0025739240
-
Regulation of the Autoactivation of Human 72-kD Progeelatinase by Tissue Inhibitor of Metalloproteinases-2
-
(1991)
J Biol Chem
, vol.266
, pp. 13064-13069
-
-
Howard1
Bullen2
Banda3
-
14
-
-
0025816440
-
Preferential Inhibition of 72- and 92-kDa Gelatinases by Tissue Inhibitor of Metalloproteinases-2
-
(1991)
J Biol Chem
, vol.266
, pp. 13070-13075
-
-
Howard1
Bullen2
Banda3
-
17
-
-
0026005356
-
Binding of Tissue Inhibitor of Metalloproteinases 2 to Two Distinct Sites on Human 72-kDa Gelatinase. Identification of a Stabilization Site
-
(1991)
J Biol Chem
, vol.266
, pp. 17972-17977
-
-
Howard1
Banda2
-
18
-
-
0021833967
-
Local Degradation of Fibronectin at Sites of Expression of the Transforming Gene Product pp60src
-
(1985)
Nature
, vol.316
, pp. 156-158
-
-
Chen1
Chen2
Parsons3
Parsons4
-
20
-
-
0023667821
-
Fibronectin-degrading proteases from the membranes of transformed cells
-
(1987)
Cell
, vol.48
, pp. 193-203
-
-
Chen1
Chen2
-
23
-
-
0026521973
-
The C-terminal Domain of 72 kDa Gelatinase A is not Required for Catalysis, but is Essential for Membrane Activation and Modulates Interactions with Tissue Inhibitors of Metalloproteinases
-
(1992)
Biochem J
, vol.283
, pp. 637-641
-
-
Murphy1
Wilenbrock2
Ward3
Cockett4
Eaton5
Docherty6
-
24
-
-
0026640236
-
The Role of the C-terminal Domain in Collagenase and Stromelysin Specificity
-
of special interest, This paper and [22] describe how the MMPs are activated on cell membranes, and the carboxyl-terminal domain of collagenase and stromelysin is essential for membrane activation and modulates interactions with TIMPs, but is not required for catalysis.
-
(1992)
J Biol Chem
, vol.267
, pp. 9612-9618
-
-
Murphy1
Allan2
Willenbrock3
Cockett4
O'Connell5
Docherty6
-
31
-
-
0025935280
-
A Metalloproteinase Inhibitor as an Inhibitor of Neovascularization
-
(1991)
J Cell Biochem
, vol.47
, pp. 230-235
-
-
Moses1
Langer2
-
33
-
-
0026033779
-
Neutral Proteinases of Human Mononuclear Phagocytes. Cellular Differentiation Markedly Alters Cell Phenotype for Serine Proteinases, Metalloproteinases, and Tissue Inhibitor of Metalloproteinases
-
(1991)
J Immunol
, vol.146
, pp. 1286-1293
-
-
Campbell1
Cury2
Shapiro3
Goldberg4
Welgus5
-
37
-
-
0026515761
-
Expression of Genes Encoding Type IV Collagen-degrading Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Various Human Tumor Cells
-
(1992)
Oncogene
, vol.7
, pp. 77-83
-
-
Sato1
Kida2
Mai3
Endo4
Sasaki5
Tanaka6
Seiki7
-
38
-
-
0025728412
-
Isolation and Characterization of a 70-kDa Metalloprotease (Gelatinase) that is Elevated in Rous Sarcoma Virus-transformed Chicken Embryo Fibroblasts
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(1991)
J Biol Chem
, vol.266
, pp. 5113-5521
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-
Chen1
Aimes2
Ward3
Youngleib4
Quigley5
-
45
-
-
0026762677
-
Inhibition of Tumor Cell Invasion by a Highly Conserved Peptide Sequence from the Matrix Metalloproteinase Enzyme Prosegment
-
of special interest, The highly conserved peptide sequence from the MMP pro-segment not only inhibits MMP activity but also blocks tumor cell invasion in vitro.
-
(1992)
Cancer Res
, vol.52
, pp. 2353-2356
-
-
Melchiori1
Albini2
Ray3
Stetler-Stevenson4
-
48
-
-
0026327376
-
Immunological Quantiation of Levels of Tissue Inhibitor of Metalloproteinase-I in Human Colon Cancer
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(1991)
Cancer Res
, vol.51
, pp. 6231-6235
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-
Lu1
Levy2
Weinstein3
Santella4
-
49
-
-
0026656315
-
Alanine Scanning Mutagenesis and Functional Analysis of the Fibronectin-like Collagen-binding Domain from Human 92-kDa Type IV Collagenase
-
of special interest, Alanine scanning mutagenesis was used to probe structural elements in the fibronectin-like collagen-binding domain of human 92 kD MMP. Changes in this domain are sufficient to alter the gelatin-binding ability of the fusion proteins.
-
(1992)
J Biol Chem
, vol.267
, pp. 6776-6781
-
-
Collier1
Krasnov2
Strongin3
Birkedal-Hansen4
Goldberg5
-
50
-
-
0025837660
-
r Active Forms of Stromelysin to Collagen is Mediated by the C-terminal Domain
-
of special interest, Stromelysin has its collagen-binding site at the carboxyl-terminal domain.
-
(1991)
J Cell Sci
, vol.99
, pp. 789-795
-
-
Allan1
Hembry2
Angal3
Reynolds4
Murphy5
-
53
-
-
0026341460
-
In Vivo Paracrine Interaction Between Urokinase and its Receptor: Effect on Tumor Cell Invasion
-
of outstanding interest, An in vivo model of invasion, consisting of the chorio-allantoic membrane of chicken embryos, was used in this study. Only cells that concurrently expressed both uPA and uPAR, and in which the receptor was saturated with uPA, were efficient in invasion. Transfection experiments have determined that uPA produced by one cell can, in a paracrine fashion, affect the invasive capacity of a receptor-expressing cell.
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(1991)
J Cell Biol
, vol.115
, pp. 1107-1112
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-
Ossowski1
Clunie2
Masucci3
Blasi4
-
54
-
-
0026046509
-
Metastatic Behavior of Human Melanoma Cell Lines in Nude Mice Correlates with Urokinase-type Plasminogen Activator, its Type-1 Inhibitor, and Urokinase-mediated Degradation
-
of outstanding interest, Plasmin-dependent degradation of a smooth muscle cell ECM by some human melanoma cell lines was mediated by tPA and others by uPA. The uPA and PAI1 producing cell lines showed the highest frequency to form spontaneous lung metastases after subcutaneous inoculation. The authors conclude that uPA-mediated matrix degradation in vitro and production of uPA and PAI1 by human melanoma cell lines correlated with their ability to form spontaneous lung metastasis in nude mice.
-
(1991)
J Cell Biol
, vol.115
, pp. 191-199
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-
Quax1
Van Muijan2
Weening-Verhoeff3
Lund4
Dano5
Ruiter6
Verheijen7
-
55
-
-
0025881037
-
Transformation-dependent Activation of Urokinase-type Plasminogen Activator by a Plasmin-dependent Mechanism: Involvement of Cell Surface Membranes
-
of special interest, The authors showed that secreted single-chain pro-uPA in Rous sarcoma virus-transformed cells was activated by an endogenous, plasmin-independent mechanism upon binding of the pro-uPA to the cell surface of transformed cells.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 7768-7772
-
-
Berkenpas1
Quigley2
-
56
-
-
0026353856
-
Single Chain Urokinase. Augmentation of Enzymatic Activity Upon Binding to Monocytes
-
of special interest, This paper examines the cell surface activation of single-chain uPA in detail.
-
(1991)
J Biol Chem
, vol.266
, pp. 14580-14584
-
-
Manchanda1
Schwartz2
-
57
-
-
0026567542
-
In Vivo and in Vitro Interaction of High and Low Molecular Weight Single-chain Urokinase-type Plasminogen Activator with Rat Liver Cells
-
of special interest, The plasma clearance and the interaction of high and low molecular weight single-chain uPA with rat liver cells was determined. A new uPA recognition site on liver cells was identified and this site was involved in the turnover of uPA.
-
(1992)
J Biol Chem
, vol.267
, pp. 1589-1595
-
-
Kuiper1
Rijken2
De Munk3
Van Berkel4
-
58
-
-
0026027969
-
Two-color Cytofluorometry and Cellular Properties of the Urokinase Receptor Associated with a Human Metastatic Carcinomatous Cell Line
-
of special interest, Cytofluorometry showed that uPA bound preferentially to cells that had been exposed to acidic pH. The data obtained by zymography of the cellular proteins suggested that the uPA was bound to the receptor. Bound uPA was found to degrade fibrin.
-
(1991)
Exp Cell Res
, vol.192
, pp. 405-413
-
-
Takahashi1
Gojobori2
Tanifuji3
-
62
-
-
0026090378
-
Modulation of Plasminogen Activation and Type IV Collagenase Activity by a Synthetic Peptide Derived from the Laminin A-chain
-
of special interest, The 19 amino acid synthetic peptide derived from the E8 fragment of the laminin A-chain is a potent stimulator of tPA-catalyzed plasminogen activation. The activity of purified type I and type IV collagenase was, however, inhibited by this peptide. This study supports the idea that this peptide stimulates plasminogen activation, subsequently generating collagense activity.
-
(1991)
Biochemistry
, vol.30
, pp. 2073-2077
-
-
Stack1
Gray2
Pizzo3
-
64
-
-
0025908960
-
Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.
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(1991)
Cancer Res
, vol.51
, pp. 3690-3695
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-
Hollas1
Balsi2
Boyd3
-
65
-
-
0025938196
-
Inhibition of Murine Melanoma Experimental Metastasis by Recombinant Desulfatohirudin, a Highly Specific Thrombin Inhibitor
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(1991)
Cancer Res
, vol.51
, pp. 4549-4556
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-
Esumi1
Fan2
Fidler3
-
67
-
-
0026509220
-
A Growth-regulated Protease Activity that is Inhibited by the Anticarcinogenic Bowman Birk Protease Inhibitor
-
of special interest, This paper shows that the anti-carcinogenic Bowman-Birk protease inhibitor complexed with its target protease is internalized and inhibits the growth-regulated activity displayed by the protease.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3120-3124
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-
Billings1
Harbres2
-
68
-
-
0026000497
-
Molecular Cloning of cDNA for Rat Cathepsin C. Cathepsin C, a Cystein Proteinase with an Extremely Long Propeptide
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(1991)
J Biol Chem
, vol.266
, pp. 16312-16317
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-
Ishidoh1
Muno2
Sato3
Kominami4
-
69
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0025772668
-
Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase.
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(1991)
Biochem J
, vol.279
, pp. 167-174
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-
Delaissé1
Ledent2
Vaes3
-
70
-
-
0026575258
-
Degradation of Extracellular-matrix Proteins by Human Cathepsin B from Normal and Tumour Tissues
-
of special interest, This paper shows that cathepsin B associated with the cell surface of tumor cells can degrade ECM components at both acidic and neutral pH. Thus, an active cathepsin B on the cell surface is implicated.
-
(1992)
Biochem J
, vol.282
, pp. 273-278
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-
Buck1
Karustis2
Day3
Honn4
Sloane5
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71
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0026510403
-
The Application of a Novel Biotinylated Affinity Label for the Detection of a Cathpsin B-like Precursor Produced by Breast-tumor Cells in culture
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(1992)
Biochem J
, vol.283
, pp. 461-465
-
-
Cullen1
Halliday2
Kay3
Nelson4
Walker5
-
72
-
-
0025413403
-
The Role of Cathepsin L in Malignant Transformation
-
of special interest, The paper presents a comprehensive overview of the role of cathepsin L in malignant transformation.
-
(1990)
Semin Cancer Biol
, vol.1
, pp. 127-136
-
-
Kane1
Gottesman2
-
73
-
-
0026596861
-
Proteolytic Processing and Glycosylation of Cathepsin B. The role of the Primary Structure of the Latent Precursor and of the Carbohydrate Moiety for Cell-type-specific Molecular Forms of the Enzyme
-
of special interest, Three excellent papers [72–74] deal with the proteolytic processing and glycosylation of cathepsin B. These properties are thought to be involved in cell surface expression of cathepsin B, and pH dependence of cathepsin B-catalyzed hydrolysis during ECM invasion of tumor cells.
-
(1992)
Biochem J
, vol.282
, pp. 577-582
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-
Mach1
Stuwe2
Hagen3
Ballaun4
Glössl5
-
74
-
-
0026661928
-
Characterization of Recombinant Rat Cathepsin B and Nonglycosylated Mutants Expressed in Yeast. New Insights into the pH Dependence of Cathepsin B-catalyzed Hydrolyses
-
of special interest, Three excellent papers [72–74] deal with the proteolytic processing and glycosylation of cathepsin B. These properties are thought to be involved in cell surface expression of cathepsin B, and pH dependence of cathepsin B-catalyzed hydrolysis during ECM invasion of tumor cells.
-
(1992)
J Biol Chem
, vol.267
, pp. 4713-4721
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Hasnain1
Hirma2
Tam3
Mort4
-
75
-
-
0026657798
-
Differential Glycosylation and Cell Surface Expression of Lysosomal Membrane Glycoproteins in Sublines of a Human Colon Cancer Exhibiting Distinct Metastatic Potentials
-
of special interest, Three excellent papers [72–74] deal with the proteolytic processing and glycosylation of cathepsin B. These properties are thought to be involved in cell surface expression of cathepsin B, and pH dependence of cathepsin B-catalyzed hydrolysis during ECM invasion of tumor cells.
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(1992)
J Biol Chem
, vol.267
, pp. 5700-5711
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Saitoh1
Wang2
Lotan3
Fukuda4
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76
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0025863753
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A Highly Sensitive e.l.i.s.a. for Endopeptidase-24.11, the Common Acute-lymphoblastic-leukaemia Antigen (CALLA, CD-10), Applicable to Material of Porcine and Human Origin
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(1991)
Biochem J
, vol.278
, pp. 417-421
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Howell1
Murray2
Scott3
Turner4
Kenny5
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77
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0025986666
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CD10 (CALLA)/Neutral Endopeptidase 24.11 Modulates Inflammatory Peptide-induced Changes in Neutrophil Morphology, Migration, and Adhesion Proteins and is itself Regulated by Neutrophil Activation
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(1991)
Blood
, vol.78
, pp. 1834-1841
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Shipp1
Stefano2
Switzer3
Griffin4
Reinherz5
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79
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0026788142
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The α Subunit of Meprin A: Molecular Cloning and Sequencing, Differential Expression in Inbred Mouse Strains, and Evidence for Divergent Evolution of the α and β Subunits
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in press
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(1992)
J Biol Chem
, vol.267
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Jiang1
Gorbea2
Flannery3
Beynon4
Grant5
Bond6
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81
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0021248709
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Expression of Transformation-associated Protease(s) that Degrade Fibronectin at Cell Contact Sites
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(1984)
J Cell Biol
, vol.98
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Chen1
Olden2
Bernard3
Chu4
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82
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A 170-kDa Membrane-bound Protease is Associated with the Expression of Invasiveness by Human Malignant Melanoma Cells
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(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 8296-8300
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Aoyama1
Chen2
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