Hyperproinsulinaemia in patients with myotonic dystrophy

Diabetologia

Volumn 35, Issue 12, 1992, Pages 1170-1172

  Krentz, A J ^a   Clark, P M ^b   Cox, L ^b   Williams, A C ^c   Nattrass, M ^a  

^a GENERAL HOSPITAL   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

insulin resistance; Myotonic dystrophy; proinsulin

Indexed keywords

PROINSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERPROINSULINEMIA; INSULIN RESISTANCE; MALE; MYOTONIC DYSTROPHY; PRIORITY JOURNAL;

C-PEPTIDE; COMPARATIVE STUDY; FASTING; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN; MYOTONIC DYSTROPHY; PROINSULIN; RADIOIMMUNOASSAY; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T;

EID: 0026463739     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00401372     Document Type: Article

References (10)

1. Abnormal regulation of intermediary metabolism after oral glucose ingestion in myotonic dystrophy
2. Insulin resistance in multiple aspects of intermediary metabolism in myotonic dystrophy
3. Insulin receptors and insulin resistance
4. The direct relationship of proinsulin-insulin hypersecretion to basal serum levels of cholesterol and triglyceride in myotonic dystrophy
5. Raised proinsulin concentration as early indication of B cell dysfunction
6. Insulin deficiency in non-insulin-dependent diabetes
7. Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65–66 split and 32–33 split proinsulins
8. Receptor binding and biological potency of several split forms (conversion intermediates) of human proinsulin. Studies in cultured IM-9 lymphocytes and in vivo and in vitro in rats
9. Hyperglycaemia as an inducer as well as a consequence of impaired islet function and insulin resistance: implications for the management of diabetes