Immunodeficiency and the Risk of Death in HIV Infection

JAMA: The Journal of the American Medical Association

Volumn 268, Issue 19, 1992, Pages 2662-2666

  Phillips, Andrew N ^a   Elford, Jonathan ^b   Sabin, Caroline ^b   Bofill, Margaritta ^b   Janossy, George ^b   Lee, Christine A ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; HEMOPHILIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MORTALITY; PRIORITY JOURNAL; SEROCONVERSION;

CAUSE OF DEATH; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMAN; LEUKOCYTE COUNT; RISK; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; ZIDOVUDINE;

EID: 0026461063     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1992.03490190062032     Document Type: Article

References (25)

1. Lane HC, Masur H, Gelmann EP, et al. Correlation between immunologic function and clinical subpopulations of patients with the acquired immune deficiency syndrome. Am J Med. 1985;78: 417-422.
2. Eyster E, Gail MH, Ballard JO, Al-Mondhiry H, Goedert JJ. Natural history of human immunodeficiency virus infections in haemophiliacs: effects of T-cell subsets, platelet counts, and age. Ann Intern Med. 1987;107:1-6.
3. Lang W, Perkins H, Anderson RE, Royce R, Jewell N, Winkelstein W. Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS. J Acquir Immune Defic Syndr. 1989;2:63-69.
4. Polk BF, Fox R, Brookmeyer R, et al. Predictors of the acquired immunodeficiency syndrome developing in a cohort of seropositive homosexual men. N Engl J Med. 1987;316:61-66.
5. Eyster ME, Ballard JO, Gail MH, Drummond JE, Goedert JJ. Predictive markers for the acquired immunodeficiency syndrome (AIDS) in haemophiliacs: persistence of p24 antigen and low T4 cell count. Ann Intern Med. 1989;110:963-969.
6. Lee CA, Phillips AN, Elford J, et al. The natural history of human immunodeficiency virus infection in a haemophiliac cohort. Br J Haematol. 1989;73: 228-234.
7. Phillips AN, Lee CA, Elford J, et al. Serial CD4 lymphocyte counts and the development of AIDS. Lancet. 1991;337:389-392.
8. Masur H, Ognibene FP, Yarchoan R, et al. CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection. Ann Intern Med. 1989;111:223-231.
9. Fahey JL, Taylor JMG, Detels R, et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med. 1990;322:166-172.
10. Goedert JJ, Kessler CM, Aledort LM, et al. A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with haemophilia. N Engl J Med. 1989;321: 1141-1148.
11. Moss AR, Bacchetti P, Osmond D, et al. Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort. BMJ. 1988; 296:745-750.
12. Phillips AN, Lee CA, Elford J, Janossy G, Kernoff PBA. The cumulative risk of AIDS as the CD4 lymphocyte count declines. J Acquir Immune Defic Syndr. 1992;5:148-152.
13. Yarchoan R, Venzon DJ, Pluda JM, et al. CD4 count and the risk for death in patients infected with HIV receiving antiretroviral therapy. Ann Intern Med. 1991;115:184-189.
14. Lee CA, Phillips AN, Elford J, Janossy G, Griffiths PD, Kernoff PBA. Progression of HIV disease in a haemophiliac cohort followed for eleven years and the effect of treatment. BMJ. 1991;303:1093-1096.
15. Centers for Disease Control. Classification system for human-T-lymphotropic virus type III/ lymph- adenopathy associated virus infections. MMWR. 1986;35:334-339.
16. Bofill M, Janossy G, Lee CA, et al. Laboratory control values for CD4 and CD8 T lymphocytes: implications for HIV-1 diagnosis. Clin Exp Immunol. 1992;88:243-252.
17. Janossy G, Pinching AJ, Bofill M, et al. An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS. Clin Exp Immunol. 1985;59:257-266.
18. Wayne WF, Steizer GT. Interlaboratory comparison of flow-r cytometric lymphocyte phenotyping analyses: implications for standardization and quality control. Cytometry. 1988;3(suppl 3):23-28.
19. Campana D, Thompson JS, Amlot P, Brown S, Janossy G. The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. J Immunol. 1987;138:648-655.
20. Langhon BE, Allandeen HS, Becker JH, et al. Summary of the workshop on future directions in discovery and development of therapeutic agents for opportunistic infections associated with AIDS. J Infect Dis. 1991;164:244-251.
21. Lee CA, Chrispeels J, Telfer P, Dusheiko G. Hepatitis C antibody profile in adults with hemophilia and their sexual partners. Br J Haematol. 1992;81:133
22. Eyster ME, Diamondstone LS, Goedert JJ, for the Multicenter Hemophilia Cohort Study. Hepatic AIDS in persons with hemophilia coinfected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Presented at the Seventh International Conference on AIDS; July 19-24,1992; Amsterdam, the Netherlands. Poster abstract PoB 3467.
23. Tedder RS, Gilson R, Briggs M, et al. Hepatitis C virus: evidence for sexual transmission. BMJ. 1991;302:1299-1302.
24. Esteban JI, Esteban R, Viladomin L, et al. Hepatitis C virus antibodies among risk groups in Spain. Lancet. 1990;335:1419-1422.
25. Weber R, Ledergerber B, Opravil M, et al. Progression of HIV infection in misusers of injected drugs who stop injecting or follow a programme of maintenance treatment with methadone. BMJ. 1990;301:1362-1365.