L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans

Journal of Clinical Investigation

Volumn 90, Issue 4, 1992, Pages 1248-1253

  Creager, Mark A ^a   Gallagher, Shelly J ^a   Girerd, Xavier J ^a,b   Coleman, Sharon M ^a   Dzau, Victor J ^a,c   Cooke, John P ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HÔPITAL BROUSSAIS   (France)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol; Endothelium; Endothelium derived relaxing factor; L arginine; Limb blood flow

Indexed keywords

ARGININE; CHOLESTEROL; ENDOTHELIUM DERIVED RELAXING FACTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; FOREARM BLOOD FLOW; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN BLOOD LEVEL; MALE; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; VASODILATATION;

ADULT; ARGININE; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN; MALE; METHACHOLINE CHLORIDE; MIDDLE AGE; NITRIC OXIDE; NITROPRUSSIDE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VASODILATION;

EID: 0026459857     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115987     Document Type: Article

References (52)

1. Vane, J. R., E. E. Änggard, and R. M. Botting. 1990. Regulatory functions of the vascular endothelium. N. Engl. J. Med. 323:27-36.
2. Furchgott, R. F., and J. V. Zawadzki. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (Lond.). 288:373-376.
3. Shepherd, J. T., and P. M. Vanhoutte. 1991. Endothelium-derived relaxing (EDRF) and contracting factors (EDCF) in the control of cardiovascular homeostasis: the pioneering observations. In Cardiovascular Significance of Endothelium-Derived Vasoactive Factors. G. M. Rubanyi, editor. Futura Publishing Co., Mt. Kisco, NY. 39-64.
4. Palmer, R. M. J., A. G. Ferridge, and S. Moncada. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond.). 327:524-526.
5. Ignarro, L. J., R. E. Byrns, G. M. Buga, and K. S. Wood. 1987. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ. Res. 61:866-879.
6. Myers, P. R., R. Guerra, and D. G. Harrison. 1989. Release of NO and EDRF from cultured bovine aortic endothelial cells. Am. J. Physiol. 256(Heart Circ. Physiol. 25):H1030-H1037.
7. Ignarro, L. J. 1989. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ. Res. 65:1-21.
8. Palmer, R. M. J., D. S. Ashton, and S. Moncada. 1988. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (Lond.). 333:664-666.
9. Sakuma, I., D. Stuehr, S. S. Gross, C. Nathan, and R. Levi. Identification of arginine as a precursor of endothelium-derived relaxing factor. 1988. Proc. Natl. Acad. Sci. USA. 85:8664-8667.
10. Palmer, R. M. J., and S. Moncada. 1989. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem. Biophys. Res. Commun. 158:348-352.
11. Marletta, M. A. 1989. Nitric oxide: biosynthesis and biological significance. Trends Biochem. Sci. 14:488-492.
12. Andrews, H. E., K. R. Bruckdorfer, R. C. Dunn, and M. Jacobs. Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. 1987. Nature (Lond.). 327:237-239.
13. Tomita, T., M. Ezaki, M. Miwa, K. Nakamura, and Y. Inoue. 1990. Rapid and reversible inhibition by low density lipoprotein of the endothelium-dependent relaxation to hemostatic substances in porcine coronary arteries. Circ. Res. 66:18-27.
14. Takahashi, M., Y. Yui, H. Yasumoto, T. Aoyama, H. Morishita, R. Hattori, and C. Kiawai. Lipoproteins are inhibitors of endothelium-dependent relaxation of rabbit aorta. 1990. Am. J. Physiol. 258 (Heart Circ. Physiol. 27):H1-H8.
15. Cohen, R. A., K. M. Zitnay, C. C. Haudenschild, and L. D. Cunningham. 1988. Loss of selective endothelial cell vasoactive functions in pig coronary arteries caused by hypercholesterolemia. Circ. Res. 63:903-910.
16. Shimokawa, H., and P. M. Vanhoutte. 1989. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ. Res. 64:900-914.
17. Bossaller, C., H. Yamamoto, P. R. Lichtlen, and P. D. Henry. 1987. Impaired cholinergic vasodilation in the cholesterol-fed rabbit in vivo. Basic Res. Cardiol. 82:396-404.
18. Osborne, J. A., M. J. Siegman, A. W. Sedar, S. U. Mooers, and A. M. Lefer. 1989. Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits. Am. J. Physiol. 256:C591-C597.
19. Wright, C. E., and J. A. Angus. 1986. Effects of hypertension and hyper-cholesterolemia on vasodilation in the rabbit. Hypertension (Dallas). 8:361-371.
20. Girerd, X. J., A. T. Hirsch, J. P. Cooke, and M. A. Creager. 1990. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ. Res. 67:1301-1308.
21. Yamamato, H., C. Bossaller, J. Cartwright, Jr., and P. D. Henry. 1988. Videomicroscopic demonstration of defective cholinergic arteriolar vasodilation in atherosclerotic rabbit. J. Clin. Invest. 81:1752-1758.
22. Creager, M. A., J. P. Cooke, M. D. Mendelsohn, S. G. Gallagher, S. M. Coleman, J. Loscalzo, and V. J. Dzau. 1990. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J. Clin. Invest. 86:228-234.
23. Zeiher, A. M., H. Drexler, H. Wollschläger, and J. Hanjörg. 1991. Modulation of coronary vasomotor tone in humans. Circulation. 83:391-401.
24. Rossitch, E., Jr., E. Alexander III, P. M. Black, and J. P. Cooke. 1991. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J. Clin. Invest. 87:1295-1299.
25. Cooke, J. P., N. A. Andon, X. J. Girerd, A. T. Hirsch, and M. A. Creager. 1991. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation. 83:1057-1062.
26. Hokanson, D. E., D. S. Sumner, and D. E. Strandness, Jr. 1975. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE (Inst. Electr. Electron. Eng.) Trans. Biomed. Eng. 22:25-29.
27. Floyd, J. C., S. S. Fajans, J. W. Conn, R. F. Knopf, and J. Rull. 1966. Stimulation of insulin secretion by amino acids. J. Clin. Invest. 9:1487-1502.
28. Creager, M. A., C.-S. Liang, and J. D. Coffman. 1985. Betaadrenergic-mediated vasodilator response to insulin in the human forearm. J. Pharmacol. Exp. Ther. 235:709-714.
29. Verbeuren, T. J., F. H. Jordaens, L. L. Zonnekeyn, C. E. Van Hove, M.-C. Coene, and A. G. Herman. 1986. Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ. Res. 58:552-564.
30. Habib, J. B., C. Bossaller, S. Wells, C. Williams, J. D. Morrisett, and P. D. Henry. 1986. Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110. Circ. Res. 58:305-309.
31. Harrison, D. G., M. L. Armstrong, P. C. Freiman, and D. D. Heistad. 1987. Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. J. Clin. Invest. 80:1808-1811.
32. Ginsberg, R., M. R. Bristow, K. Davies, A. Didiasc, and M. E. Billingham. 1984. Quantitative pharmacologic responses of normal and atherosclerotic isolated human epicardial coronary arteries. Circulation. 69:430-440.
33. Ludmer, P. L., A. P. Selwyn, T. L. Shook, R. R. Wayne, G. H. Mudge, R. W. Alexander, and P. Ganz. 1986. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N. Engl. J. Med. 315:1046-1051.
34. Vita, J. A., C. B. Treasure, E. G. Nabel, J. M. McLenachan, R. D. Fish, A. C. Yeung, V. I. Vekshtein, A. P. Selwyn, and P. Ganz. 1990. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 81:491-497.
35. Tagawa, H., H. Tomoike, and M. Nakamura. 1991. Putative mechanisms of the impairment of endothelium-dependent relaxation of the aorta with atheromatous plaque in heritable hyperlipidemic rabbits. Circ. Res. 68:330-337.
36. Minor, R. L., Jr., P. R. Myers, R. Guerra, Jr., J. N. Bates, and D. G. Harrison. 1990. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest. 86:2109-2116.
37. Simon, B. C., L. D. Cunningham, and R. A. Cohen. 1990. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J. Clin. Invest. 86:75-79.
38. Galle, J., E. Bassenge, and R. Busse. 1990. Oxidized low density lipoproteins potentiate vasoconstriction to various agonists by direct interaction with vascular smooth muscle. Circ. Res. 66:1287-1293.
39. Thomas, G., R. Vargas, B. Wroblewska, and P. W. Ramwell. 1989. Role of the endothelium and arginine peptides on the vasomotor response of porcine internal mammary artery. Life Sci. 44:1823-1830.
40. Aisaka, K., S. S. Gross, O. W. Griffith, and R. Levi. 1989. NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem. Biophys. Res Commun. 160:881-886.
41. Amezcua, J. L., R. M. J. Palmer, B. M. DeSouza, and S. Moncada. 1989. Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br. J. Pharmacol. 97:1119-1124.
42. Rees, D. D., R. M. J. Palmer, and S. Moncada. 1989. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA. 86:3375-3378.
43. Palmer, R. M., D. D. Rees, D. S. Ashton, and S. Moncada. 1988. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun. 153:1251-1256.
44. Gold, M. E., K. S. Wood, G. M. Buga, R. E. Byrns, and L. J. Ignarro. 1989. L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation. Biochem. Biophys. Res. Commun. 161:536-543.
45. Gold, M. E., K. S. Wood, R. E. Byrns, G. M. Buga, and L. J. Ignarro. 1990. L-arginine-dependent vascular smooth muscle relaxation and cGMP formation. Am. J. Physiol. 259:H1813-H1821.
46. Schini, V. B., and P. M. Vanhoutte. 1991. Endothelium-dependent and -independent relaxations in L-arginine-depleted aortas of the rat. Circ. Res. 68:209-216.
47. Vallance, P., J. Collier, and S. Moncada. 1989. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. ii:997-1000.
48. Linder, L., W. Kiowski, F. R. Bühler, and T. F. Lüscher. 1990. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Circulation. 81:1762-1767.
49. Panza, J. A., A. A. Quyyumi, J. E. Brush, Jr., and S. E. Epstein. 1990. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323:22-27.
50. Shimokawa, H., and P. M. Vanhoutte. 1988. Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation. 78:1421-1430.
51. Osborne, J. A., P. H. Lento, M. R. Siegfried, G. L. Stahl, B. Fusman, and A. M. Lefer. 1989. Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment. J. Clin. Invest. 83:465-473.
52. Ross, R. 1986. The pathogenesis of atherosclerosis: an update. N. Engl. J. Med. 314:488-500.