Thrombin Receptor Activating Peptides: Importance of the N-Terminal Serine and Its Ionization State As Judged by pH Dependence, Nuclear Magnetic Resonance Spectroscopy, and Cleavage by Aminopeptidase M

Biochemistry

Volumn 31, Issue 47, 1992, Pages 11713-11720

  Coller, Barry S ^a   Scudder, Lesley E ^a   Springer, Karen ^a   Kutok, Jeffery ^a   Ward, Patrick ^b   Ceruso, Marco ^c   Prestwichl, Glenn D ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; AMASTATIN; BESTATIN; CAPTOPRIL; MICROSOMAL AMINOPEPTIDASE; PUROMYCIN; RECEPTOR; SERINE; THROMBIN;

ACETYLATION; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; IONIZATION; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANTIGENS, CD13; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMAN; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; RECEPTORS, CELL SURFACE; RECEPTORS, THROMBIN; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026459474     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00162a007     Document Type: Article

References (54)

1. Ahmad, S., & Ward, P.E. (1990) J. Pharmacol. Exp. Ther. 252, 643-650.
2. Ahmad, S., Wang, L., & Ward, P.E. (1992) J. Pharmacol. Exp. Ther. 260, 1257-1261.
3. Baenziger, N.L., Brodie, G.N., & Majerus, P.W. (1971) Proc. Natl. Acad. Sci. U.S.A. 68, 240.
4. Basus, V.J. (1989) in Methods in Enzymology (Oppenheimer, N.J., & James, T.L., Eds.) Vol. 177, pp 132-149, Academic Press Inc., New York.
5. Bax, A., & Davis, D.G. (1985 a) J. Magn. Reson. 63, 207-213.
6. Bax, A., & Davis, D.G. (1985 b) J. Magn. Reson. 65, 355-360.
7. Beer, J.H., Springer, K.T., & Coller, B.S. (1992) Blood 79, 117-128.
8. Billeter, M., Braun, W., & Wuthrich, K. (1982) J. Mol. Biol. 155, 321-326.
9. Bodenhausen, G., Kogler, H., & Ernst, R.R. (1984) J. Magn. Reson. 58, 370-388.
10. Bothner-By, A.A., Stephens, R.L., Lee, J.M., Warren, C.D., & Jeanloz, R.W. (1986) J. Am. Chem. Soc. 106, 811-813.
11. Brass, L.F. (1992) J. Biol. Chem. 267, 6044-6050.
12. Brass, L.F., & Woolkalis, M.J. (1992) Biochem. J. 281, 72-80.
13. Brass, L.F., Vassallo, R.R., Jr., Belmonte, E., Ahujz, M., Cichowski, K., & Hoxie, J.A. (1992) J. Biol. Chem. 267, 13795-13768.
14. Charo, I.F., Feinman, R.D., & Detwiler, T.C. (1977) J. Clin. Invest. 60, 866-873.
15. Chesebro, J.H., & Fuster, V. (1991) Circulation 83, 1815-1817.
16. Churchill, L., Bausback, H.H., Gerritsen, M.E., & Ward, P.E. (1987) Biochim. Biophys. Acta 923, 35-41.
17. Coller, B.S. (1977) J. Clin. Invest. 61, 1168-1175.
18. Coller, B.S., Franza, B.R., Jr., & Gralnick, H.R. (1976) Blood 47, 841-854.
19. Coller, B.S., Peerschke, E.I., Scudder, L.E., & Sullivan, C.A. (1983) J. Clin. Invest. 72, 325-338.
20. Davey, M.G., & Luscher, E.F. (1968) Biochim. Biophys. Acta 165, 490-506.
21. Davis, D.G., & Bax, A. (1985) J. Am. Chem. Soc. 107, 2820-2822.
22. Detwiler, T.C., Chang, A.C., Speziale, M.V., Browne, P.C., Miller, J.J., & Chen, K. (1992) Semin. Thromb. Hemostasis 18, 60-66.
23. Forbes, C.D., & Madhok, R. (1991) in Disorders of Hemostasis (Ratnoff, O.D., Ed.) p 141, W.B. Saunders, Philadelphia, PA.
24. Ganguly, P., & Gould, N.L. (1979) Br. J. Haematol. 42, 137-145.
25. Grette, K. (1962) Acta Physiol. Scand. 56, (Suppl.), 195.
26. Gronke, R.S., Bergman, B.C., & Baker, J.B. (1987) J. Biol. Chem. 262, 3030-3036.
27. Hagen, I., Brosstad, F., Solum, N.O., & Korsmo, R. (1981) J. Lab. Clin. Med. 97, 213-270.
28. Hersh, L.B., Aboukhair, N., & Watson, S. (1987) Peptides 8, 523-532.
29. Huang, R., Sorisky, A., Church, W., Simons, E.R., & Rittenhouse, S.E. (1991) J. Biol. Chem. 266, 18435-18438.
30. Hung, D., Vu, T.-K.H., Nelken, N.A., & Coughlin, S.R. (1992) J. Cell Biol. 116, 827-832.
31. Kenny, A.J. (1977) in Proteinases in Mammalian Cells and Tissues (Barrett, A.J., Ed.) pp 393-444, Biomedical Press, Elsevier/North Holland, Amsterdam.
32. Kurauchi, O., Mizutani, S., Okano, K., Narita, O., & Tomoda, Y. (1986) Enzyme 35, 197-205.
33. Levine, M.N., & Hirsh, J. (1986) Semin. Thromb. Hemostasis 12, 39-57.
34. McDonald, J.K., & Schwabe, C.H. (1986) Exopeptidases, Vol. 2, Academic Press, New York.
35. Marion, D., & Wuthrich, K. (1983) Biochem. Biophys. Res. Commun. 113, 967-974.
36. Martin, B., Feinman, R.D., & Detwiler, T.C. (1975) Biochemistry 14, 1308-1314.
37. Neuenschwander, P., & Jesty, J. (1988) Blood 72, 1761-1770.
38. Ngaiza, J.R., & Jaffe, E.A. (1991) Biochem. Biophys. Res. Commun. 179, 1656-1661.
39. Okumura, T., Hasitz, M., & Jamieson, G.A. (1978) J. Biol. Chem. 253, 3435-3443.
40. Palmieri, F.E., Bausback, H.H., & Ward, P.E. (1989) Biochem. Pharmacol. 38, 173-180.
41. Phillips, D.R., & Agin, P.P. (1977) Biochem. Biophys. Res. Commun. 75, 940-947.
42. Ranee, M., Sorensen, O.W., Bodenhausen, G., Wagner, G., Ernst, R.R., & Wuthrich, K. (1983) Biochem. Biophys. Res. Commun. 117, 479-485.
43. Rasmussen, U.B., Vouret-Craviari, V., Jallat, S., Schlesinger, Y., Pages, G., Pavirani, A., Lecocq, J.-P., Pouyssegur, J., & Van Obberghen-Schilling, E. (1991) FEBS Lett. 288, 123-128.
44. Takamatsu, J., Home, M.K., III, & Gralnick, H.R. (1986) J. Clin. Invest. 77, 362-368.
45. Vassallo, R.R., Jr., Kieber-Emmons, T., Cichowski, K., & Brass, L.F. (1992) J. Biol. Chem. 267, 6081-6085.
46. Vouret-Craviari, V., Van Obberghen-Schilling, E., Rasmussen, U.B., Pavirani, A., Lecocq, J.-P., & Pouyssegur, J. (1992) Mol. Biol. Cell 3, 95-102.
47. Vu, T.-K.H., Hung, D.T., Wheaton, V.I., & Coughlin, S.R. (1991 a) Cell 64, 1057-1068.
48. Vu, T.-K.H., Wheaton, V.I., Hung, D.T., Charo, I., & Coughlin, S.R. (1991 b) Nature 353, 674-677.
49. Wang, L., Ahmad, S., Benter, I.F., Chow, A., Mizutani, S., & Ward, P.E. (1991) Peptides 12, 1357-1364.
50. Ward, P.E., Benter, I.F., Dick, L., & Wilk, S. (1990) Biochem. Pharmacol. 40, 1725-1732.
51. Wuthrich, K. (1983) Biopolymers 22, 131-138.
52. Wuthrich, K., Wider, G., Wagner, G., & Braun, W. (1982) J. Mol. Biol. 155, 311-319.
53. Wuthrich, K., Billeter, M., & Braun, W. (1984) J. Mot. Biol. 180, 715-740.
54. Zucker, M.B., & Borelli, J. (1955) J. Appl. Physiol. 7, 432.