Oxidative stress induced by administration of the neuroleptic drug haloperidol is attenuated by higher doses of haloperidol

Brain Research

Volumn 595, Issue 2, 1992, Pages 256-262

  Shivakumar, Bangalore R ^a   Ravindranath, Vijayalakshmi ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Brain; Glutathione; Haloperidol; Lipid peroxidation; Neuroleptic; Oxidative stress; Protein glutathione mixed disulfide; Protein thiol

Indexed keywords

GLUTATHIONE; HALOPERIDOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; CEREBRAL CORTEX; CORPUS STRIATUM; DISULFIDES; FLUORESCENT DYES; GLUTATHIONE; HALOPERIDOL; HOMEOSTASIS; LIPID PEROXIDATION; MALONDIALDEHYDE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; STRESS; SUPPORT, NON-U.S. GOV'T;

EID: 0026458952     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(92)91058-M     Document Type: Article

References (31)

1. Assay of glutathione, glutathione disulfide and glutathione mixed disulfide in biological samples
2. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
3. Hydrogen peroxide production in dopamine neurons: implications for understanding parkinson's disease
4. Oxy-radical toxicity in catecholamine neurons
5. Deprenyl suppresses the oxidant stress associated with increased dopamine turnover
6. Alterations in intracellular thiol homeostases during the metabolism of menadione by isolated rat hepatocytes
7. Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskenia
8. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
9. Persistent neuroleptic dysknesia associated with regional changes within brain GABA an dopamine systems
10. Therapeutic approaches to tardive dysknesia: a review of the literature
11. Drug therapy of tardive dyskinesia
12. Reduced haloperidol: effects on striatal dopamine metabolism and conversion to haloperidol in the rat
13. The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis
14. Organometal induced increases in oxygen reactive species: the potential of 2′, 7′-dichlorofluorescin diacetate as an index of neurotoxic damage
15. Vitamin E in the treatment of tardive dyskinesia: the possible involvement of free radical mechanisms
16. Glutathione
17. Spontaneous and drug induced movement disorders in psychiatry patients
18. High dosage of haloperidol in chronic schizophrenia
19. Glutathione
20. Assay of lipid peroxidese in animal tissues by thiobarbituric acid reaction
21. Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment
22. Chemical depletion of glutathione in vivo
23. Glutathione depletion and formation of glutathione protein mixed disulfide following exposure of brain mitochondria to oxidative stress
24. Extrapyramidal side effects: a historical perspective
25. Spectrophotometric assay of oxidized glutathione using iodoacetic acid and enzymatic recycling-method
26. Reduced and oxidized glutathione in human and monkey brain
27. Preferential effects of 1,3 bis(2-chloro-ethyl)-1-nitrosourea (BCNU) on pulmonary glutathione reductase and glutathione/glutathione disulfide ratios: possible implications for lung toxicity
28. Rapid control of psychotic excitement states with intramuscular haloperidol
29. Brain receptors for antipsychotic drugs and dopamine: direct binding assays
30. Antipsychotic drug doses and neuroleptic/dopamine receptors
31. Enzymatic method for quantitative determination of manogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues