Differential toxicity of cocaine and its isomers, (+)-cocaine and (-)-Ψ-cocaine, is associated with stereoselective hydrolysis by hepatic carboxylesterases in cultured rat hepatocytes

Chemico-Biological Interactions

Volumn 84, Issue 3, 1992, Pages 243-258

  Melchert, Russell B ^a,b   Göldlin, Christian ^a   Zweifel, Ulrich ^a   Welder, Allison A ^b   Boelsterli, Urs A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Carboxylesterases; Cocaine; Cultured rat hepatocytes; Cytotoxicity; Isomer specific toxicity

Indexed keywords

CARBOXYLESTERASE; COCAINE; COCAINE DERIVATIVE; GLUTATHIONE; PROADIFEN;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG HYDROLYSIS; ISOMER; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY;

ANIMAL; CARBOXYLIC ESTER HYDROLASES; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; COCAINE; GLUTATHIONE; HYDROLYSIS; LACTATE DEHYDROGENASE; LIVER; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T;

ANIMALIA;

EID: 0026455201     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(92)90127-7     Document Type: Article

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