Site-Directed Mutations That Alter the Inhibitory Activity of the Tissue Inhibitor of Metalloproteinases-1: Importance of the N-Terminal Region between Cysteine 3 and Cysteine 13

Biochemistry

Volumn 31, Issue 42, 1992, Pages 10146-10152

  O'Shea, Mark ^a   Reynolds, John J ^a   Murphy, Gillian ^a   Willenbrock, Frances ^b   Williamson, Richard A ^c   Freedman, Robert B ^c   Cockett, Mark I ^d   Docherty, Andrew J P ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF KENT   (United Kingdom)

^d UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUTAMINE; HISTIDINE; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME REGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BINDING SITES; CYSTEINE; GENETIC VECTORS; GLYCOPROTEINS; HUMAN; KINETICS; METALLOENDOPEPTIDASES; MICE; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN DENATURATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; STROMELYSIN 1; SUPPORT, NON-U.S. GOV'T; THERMODYNAMICS; TISSUE INHIBITOR OF METALLOPROTEINASES; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA;

EID: 0026453778     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00157a002     Document Type: Article

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