Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease

New England Journal of Medicine

Volumn 327, Issue 22, 1992, Pages 1541-1548

  Spencer, Dennis D ^a   Robbins, Richard J ^a   Naftolin, Frederick ^a   Marek, Kenneth L ^a   Vollmer, Timothy ^a   Leranth, Csaba ^a   Roth, Robert h ^a   Price, Lawrence H ^a   Gjedde, Albert ^b   Bunney, Benjamin S ^a   Sass, Kimberlee J ^a   Elsworth, John D ^a   Kier, E Leon ^a   Makuch, Robert ^a   Hoffer, Paul B ^a   Redmond, D Eugene ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIDOPA PLUS LEVODOPA; CYCLOSPORIN A; DOPAMINE RECEPTOR STIMULATING AGENT;

ADULT; ARTICLE; BRAIN METABOLISM; BRAIN TISSUE; BRAIN TRANSPLANTATION; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINE METABOLISM; FEMALE; FETUS; HUMAN; HUMAN TISSUE; MALE; MESENCEPHALON; MOTOR ACTIVITY; NIGRONEOSTRIATAL SYSTEM; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; TASK PERFORMANCE; TISSUE DEGENERATION;

ACTIVITIES OF DAILY LIVING; ADULT; ANTIPARKINSON AGENTS; CASE REPORT; CAUDATE NUCLEUS; CRYOPRESERVATION; CYCLOSPORINE; DOPAMINE; FEMALE; FETAL TISSUE TRANSPLANTATION; HOMOVANILLIC ACID; HUMAN; MAGNETIC RESONANCE IMAGING; MALE; MESENCEPHALON; MIDDLE AGE; MOTOR ACTIVITY; PARKINSON DISEASE; PUTAMEN; STEREOTAXIC TECHNIQUES; SUPPORT, NON-U.S. GOV'T; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0026447667     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199211263272201     Document Type: Article

References (63)

1. Bemheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington: clinical, morphological and neurochemical correlations. J Neural Sci 1973; 20: 415–55.
2. Rinne UK. Dopamine agonists as primary treatment in Parkinson's disease. Adv Neural 1987; 45: 519–23.
3. Weiner WJ, Lang AE. Movement disorders — a comprehensive survey. Mount Kisco, N.Y.: Futura, 1989.
4. Lund RD, Hauschka SD. Transplanted neural tissue develops connections with host rat brain. Science 1976; 193: 582–4.
5. Perlow MJ, Freed WJ, Hoffer BJ, Seiger A, Olson L, Wyatt RJ. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 1979; 204: 643–7.
6. Björklund A, Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 1979; 177: 555–60.
7. Stromberg I, Bygdeman M, Goldstein M, Seiger A, Olson L. Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosup pressed rats: evidence for functional reinnervation. Neurosci Lett 1986; 71: 271–6.
8. Björklund A, Stenevi U. Intracerebral neural implants: neuronal replacement and reconstruction of damaged circuitries. Annu Rev Neurosci 1984; 7: 279–308.
9. Brundin P, Strecker RE, Lindvall O, et al. Intracerebral grafting of dopamine neurons: experimental basis for clinical trials in patients with Parkinson's disease. Ann N Y Acad Sci 1987; 495: 473–96.
10. Redmond DE Jr, Sladek JR Jr, Roth RH. Transplanted cells: a future treatment for Parkinson's disease? Neurologic Consultant 1987; 4: 1–8 (newsletter sponsored by Dupont Pharmaceuticals).
11. Redmond DE, Sladek JR Jr, Roth RH, et al. Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet 1986; 1: 1125–7.
12. Sladek JR Jr, Collier TJ, Haber SN, Roth RH, Redmond DE Jr. Survival and growth of fetal catecholamine neurons transplanted into primate brain. Brain Res Bull 1986; 17: 809–18.
13. Bakay RAE, Barrow DL, Fiandaca MS, Iuvone PM, Schiff A, Collins DC. Biochemical and behavioral correction of MPTP Parkinson-like syndrome by fetal cell transplantation. Ann N Y Acad Sci 1987; 495: 623–40.
14. Fine A, Hunt SP, Oertel WH, et al. Transplantation of embryonic marmoset dopaminergic neurons to the corpus striatum of marmosets rendered parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. In: Gash DM, Sladek JR Jr, eds. Transplantation into the mammalian CNS. Vol 78 of Progress in brain research. Amsterdam: Elsevier, 1988:479–89.
15. Bankiewicz KS, Plunkett RJ, Jacobowitz DM, et al. The effect of fetal mesencephalon implants on primate MPTP-induced parkinsonism: histochemical and behavioral studies. J Neurosurg 1990; 72: 231–44.
16. Collier TJ, Redmond DE Jr, Sladek CD, Gallagher MJ, Roth RH, Sladek JR Jr. Intracerebral grafting and culture of cryopreserved primate dopamine neurons. Brain Res 1987; 436: 363–6.
17. Redmond DE Jr, Naftolin F, Collier TJ, et al. Cryopreservation, culture, and transplantation of human fetal mesencephalic tissue into monkeys. Science 1988; 242: 768–71.
18. Embryonic brain cell transplantation for the treatment of central nervous system disorders: ethical issues and questions: proceedings of a symposium, New Haven, Conn., February 26, 1987. New Haven: Morse College, Yale University, 1987.
19. Mahowald MB, Areen J, Hoffer BJ, et al. Transplantation of neural tissue from fetuses. Science 1987; 235: 1307–8.
20. Report of the Human Fetal Tissue Transplantation Research Panel. Washington, D.C.: National Institutes of Health, 1988.
21. Redmond DE Jr, Spencer D, Naftolin F, et al. The ethics of research using human fetal tissue. N Engl J Med 1989; 321: 1609.
22. Madrazo I, León V, Torres C, et al. Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson's disease. N Engl J Med 1988; 318: 51.
23. Hitchcock ER, Clough C, Hughes R, Kenny B. Embryos and Parkinson's disease. Lancet 1988; 1: 1274.
24. Madrazo I, Franco-Bourland R, Ostrosky-Solis F, et al. Fetal homotrans-plants (ventral mesencephalon and adrenal tissue) to the striatum of parkinsonian subjects. Arch Neural 1990; 47: 1281–5.
25. Freed CR, Breeze RE, Rosenberg NL, et al. Transplantation of human fetal dopamine cells for Parkinson's disease: results at 1 year. Arch Neural 1990; 47: 505–12.
26. Lindvall O, Brundin P, Widner H, et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 1990; 247: 574–7.
27. Lindvall O, Widner H, Rehncrona S. et al. Transplantation of fetal dopamine neurons in Parkinson's disease: one-year clinical and neurophysiological observations in two patients with putaminal implants. Ann Neurol 1992; 31: 155–65.
28. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967; 17: 427–42.
29. Langston JW, Widner H, Goetz CG, et al. Core assessment program for intracerebral transplantations (CAPIT). Mov Disord 1992; 7: 2–13.
30. Fahn S, Elton RL, Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Recent developments in Parkinson's disease. Vol. 2. Florham Park, N.J.: Macmillan Healthcare Information, :153–64.
31. Schwab RS, England achéal Jr. Projection technique for evaluating surgery in Parkinson's disease. In: Gillingham FJ, Donaldson IML, eds. Third Symposium on Parkinson's disease, Edinburgh, Scotland, May 20–22, 1968. Edinburgh, ScoUand: E. & S. Livingstone, 1969:152–7.
32. Lezak MD. Neuropsychological assessment. 2nd ed. New York: Oxford University Press, 1983.
33. Spitzer RL, Endicott J. Schedule for affective disorders and schizophrenia (SADS). New York: New York State Psychiatric Institute, 1978.
34. Eating disorders. In: Diagnostic and statistical manual of mental disorders: DSM-III-R. 3rd ed. rev. Washington, D.C: American Psychiatric Association, 1987:65–7.
35. Redmond DE Jr, Robbins RJ, Naftolin F, et al. Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients. In: Waxman SG, ed. Molecular and cellular approaches to the treatment of brain disease. New York: Raven Press (in press).
36. Elsworth JD, Deutch AY, Redmond DE Jr, Taylor JR, Sladek JR Jr, Roth RH. Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetiahydropyridine-treated primates: biochemical changes in striatal regions. Neuroscience 1989; 33: 323–31.
37. Lups S, Haan AMFH. The cerebrospinal fluid. Amsterdam: Elsevier, 1954.
38. Evans achéal, Thompson CJ, Marrett S, Meyer E, Mazza M. Performance evaluation of the PC-2048: a new 15 slice encoded crystal PET scanner for neurological studies. IEEE Trans Med Imaging 1991; 10: 90–8.
39. Evans achéal, Marrett S, Torrescorzo J, Ku S, Collins L. MRI—PET correlation in three dimensions using a volume-of-interest (VOI) atlas. J Cereb Blood Flow Metab 1991; 11: A69–A78.
40. Gjedde A, Reith J, Dyve S, et al. Dopa decarboxylase activity of the living human brain. Proc Natl Acad Sci U S A 1991; 88: 2721–5.
41. Hoshi H, Kuwabara H, Léger G, Cumming P, Guttman M, Gjedde A. 6-[18F]fluoro-L-DOPA metabolism in living human brain: a comparison of six analytical methods. J Cereb Blood Flow Metab (in press).
42. Robbins RJ, Torres-Aleman I, Leranth C, et al. Cryopreservation of human brain tissue. Exp Neural 1990; 107: 208–13.
43. Greely HT, Hamm T, Johnson R, et al. The ethical use of human fetal tissue in medicine. N Engl J Med 1989; 320: 1093–6.
44. Hoffer BJ, Olson L. Ethical issues in brain-cell transplantation. Trends Neurosci 1991; 14: 384–8.
45. Landon RM, Robbins R. Somatostatin release from dissociated cerebral cortical cell cultures. In: Conn PM, ed. Hormone action. Vol. 124 of Methods in enzymology. Orlando, Fla.: Academic Press, 1986:412–24.
46. McCarthy G, Spencer DD, Riker RJ. The stereotaxic placement of depth electrodes in epilepsy. In: Lüders H, ed. Epilepsy surgery. New York: Raven Press, 1991:385–93.
47. SAS/STAT user's guide, release 6.03 ed. Cary, N.C.: SAS Institute, 1988.
48. Rice WR. A consensus combined P-value test and the family-wide significance of component tests. Biometrics 1990; 46: 303–8.
49. Redmond DE Jr, Leranth C, Spencer DD, et al. Fetal neural graft survival. Lancet 1990; 336: 820–2.
50. Geminiani G, Cesana BM, Tamma F, et al. Interobserver reliability between neurologists in training of Parkinson's disease rating scales: a multicenter study. Mov Disord 1991; 6: 330–5.
51. Detta A, Hitchcock E. The selective viability of human foetal brain cells. Brain Res 1990; 520: 277–83.
52. Taylor JR, Elsworth JD, Roth RH, Collier TJ, Sladek JR Jr, Redmond DE Jr. Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. In: Dunnett SB, Richards S-J, eds. Neural transplantation: from molecular basis to clinical applications. Vol. 82 of Progress in brain research. Amsterdam: Elsevier, 1990:543–59.
53. Taylor JR, Elsworth JD, Roth RH, Sladek JR Jr, Collier TJ, Redmond DE Jr. Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls. Exp Brain Res 1991; 85: 335–48.
54. Gill TJ III, Lund RD. Implantation of tissue into the brain: an immunologic perspective. JAMA 1989; 261: 2674–6.
55. Rosenfeld JV, Bartlett PF, Kerr RSC. Tissue grafting and immunosuppression. J Neurosurg 1991; 74: 157–9.
56. Lund RD, Rao K, Kunz HW. Gill TJ III. Immunological considerations in neural transplantation. Transplant Proc 1989; 21: 3159–62.
57. Widner H, Brundin P. Immunological aspects of grafting in the mammalian central nervous system: a review and speculative synthesis. Brain Res 1988; 472: 287–324.
58. Lindvall O, Rehncrona S, Brundin P, et al. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease: a detailed account of methodology and a 6-month follow-up. Arch Neurol 1989; 46: 615–31.
59. Henderson BTH, Clough CG, Hughes RC, Hitchcock ER, Kenny BG. Implantation of human fetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson's disease. Arch Neurol 1991; 48: 822–7.
60. Freed WJ. Fetal brain grafts and Parkinson's disease. Science 1990; 250: 1434.
61. Steece-Collier K, Collier TJ, Sladek CD, Sladek JR Jr. Chronic levodopa impairs morphological development of grafted embryonic dopamine neurons. Exp Neurol 1990; 110: 201–8.
62. Bunney BS, Sesack SR, Silva NL. Midbrain dopaminergic systems: neurophysiology and electrophysiological pharmacology. In: Meltzer HY, ed. Psychopharmacology: the third generation of progress. New York: Raven Press, 1987:113–26.
63. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990; 13: 266–71.