Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4

Journal of Clinical Investigation

Volumn 90, Issue 4, 1992, Pages 1479-1485

  Postlethwaite, Arnold E ^a,b   Holness, Maureen A ^a,b   Katai, Hitoshi ^a,b   Raghow, Rajendra ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Collagen; Fibrogenesis; Fibronectin; Fibrosis; Wound healing

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COMPLEMENTARY RNA; FIBRONECTIN; INTERLEUKIN 4; MESSENGER RNA; PROCOLLAGEN; RECOMBINANT INTERLEUKIN 4; RIBONUCLEASE;

ARTICLE; COLLAGEN SYNTHESIS; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROGENESIS; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RHEUMATOID ARTHRITIS; RNA RNA HYBRIDIZATION; RNA TRANSLATION; SKIN FIBROBLAST; SYNOVIOCYTE; WOUND HEALING;

CELLS, CULTURED; COLLAGEN; FIBROBLASTS; FIBRONECTINS; HUMAN; INTERLEUKIN-4; PROCOLLAGEN; RECOMBINANT PROTEINS; RNA, MESSENGER; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026446005     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116015     Document Type: Article

References (30)

1. Howard, M., J. Farrar, M. Hilfiker, B. Johnson, K. Takatsu, T. Hamaoka, and W. E. Paul. 1982. Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J. Exp. Med. 155:914-923.
2. Vitetta, E. S., K. Brooks, Y.-W. Chen, P. Isakson, S. Jones, J. Layton, G. C. Mishra, E. Pure, E. Weiss, C. Ward, et al. 1984. T cell-derived lymphocytes that induce IgM and IgG secretion in activated murine B cells, Immunol. Rev. 78:137-157.
3. Sideran, P., S. Bergstedt-Lindquist, and E. Severinson. 1985. Partial biochemical characterization of IgGl-inducing factor. Eur. J. Immunol. 150:593-598.
4. Lee, F., T. Yokota, T. Otsuka, P. Meyerson, D. Villaret, R. Coffman, T. Mosmann, D. Rennick, N. Roehm, C. Smith, et al. 1986. Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell and mast-cell-stimulating activities. Proc. Natl. Acad Sci. USA. 83:2061-2066.
5. Noma, Y., P. Sideras, T. Naito, S. Bergstedt-Lindquist, C. Azuma, E. Severinson, T. Tanabe, T. Kinashi, F. Matsuda, Y. Yaoita, and T. Honjo. 1986. Cloning of cDNA encoding the murine IgG1 inducing factor by a novel strategy using SP6 promoter. Nature (Lond.). 319:640-646.
6. Isakson, P. C. 1986. Antiimmunoglobulin-treated B cells respond to a B cell differentiation factor for IgGl. J. Exp. Med. 164:303-308.
7. Coffman, R. L., J. Ohara, M. W. Bond, J. Carty, A. Zlotnik, and W. E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538-4541.
8. Roehm, N. W., H. J. Leibson, A. Zlotnik, J. Kappler, P. Marrack, and J. C. Cambier. 1984. Interleukin-induced increase in Ia expression by normal mouse B cells. J. Exp. Med. 160:679-694.
9. Noelle, R., P. H. Krammer, J. W. Uhr. and E. S. Vitetta. 1984. Increased expression of Ia antigens on reacting B cells: an additional role for B-cell growth factor. Proc. Natl. Acad. Sci. USA. 811:6149-6153.
10. Ohara, J., and W. E. Paul. 1987. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (Lond.). 325:537-540.
11. Park, L. S., D. Friend, H. M. Sassenfeld, and D. L. Urdal. 1987. Characterization of the human B cell stimulatory factor 1 receptor. J. Exp. Med. 166:476-488.
12. Lowenthal, J. W., B. E. Castle, J. Christiansen, J. Schreurs, D. Reunick, N. Arai, P. Hoy, Y. Takebe, and M. Howard. 1988. Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. J. Immunol. 140:456-464.
13. Monroe, J. G., S. Haldar, M. B. Prystowsky, and P. Lammie. 1988. Lymphokine regulation of inflammatory processes: interleukin-4 stimulates fibroblast proliferation. Clin. Immunol. Immunopathol. 49:292-298.
14. Postlethwaite, A. E., and J. M. Seyer. 1991. Fibroblast chemotaxis induction by human recombinant interleukin-4: identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122. J. Clin. Invest. 87:2147-2152.
15. Wood, D. D., E. K. Bayne, M. B. Goldring, M. Gowen, D. Hamerman, J. L. Humes, E. J. Ihrie, P. E. Lipsky, and M. J. Staruch. 1985. The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities. J. Immunol. 134:895-903.
16. Grabstein, K., J. Eisenmann, D. Mochizuki, K. Shanebeck, P. Conlon, T. Hopp, C. March, and S. Gillis. 1986. Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines. J. Exp. Med. 163:1405-1414.
17. Yokota, T., T. Otsuka, T. Mosmann, J. Banchereau, T. DeFrance, D. Blanchard, J. E. DeVries, F. Lee, and K. Arai. 1986. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc. Natl. Acad. Sci. USA. 83:5894-5898.
18. Postlethwaite, A. E., G. N. Smith, C. L. Mainardi, J. M. Seyer, and A. H. Kang. 1984. Lymphocyte modulation of fibroblasts in vitro: stimulation and inhibition of collagen production by different effector molecules. J. Immunol. 132:2470-2477.
19. Raghow, R., D. Gossage, and A. H. Kang. 1986. Pretranslational regulation of type I procollagen, fibronectin and a 50 kilodalton noncollagenous extracellular matrix protein by dexamethasone in rat fibroblasts. J. Biol. Chem. 261:4677-4684.
20. Raghow, R., D. Gossage, J. M. Seyer, and A. H. Kang. 1984. Transcriptional regulation of type I collagen genes in cultured fibroblasts by a factor isolated from thioacetamide induced fibrotic rat liver. J. Biol. Chem. 259:12718-12723.
21. Aycock, R. S., R. Raghow, G. P. Stricklin, J. M. Seyer, and A. H. Kang. 1986. Post-transcriptional inhibition of collagen and fibronectin synthesis by a synthetic homolog of a portion of the carboxyl terminal propeptide of human type I collagen. J. Biol. Chem. 261:14335-14360.
22. Thomas, P. S. 1983. Hybridization of denatured RNA transferred or dotted to nitrocellulose paper. Methods Enzymol. 100:255-266.
23. Chu, M. L., J. C. Myers, M. P. Bernard, J. F. Ding, and F. Ramirez. 1983. Cloning and characterization of five overlapping cDNAs specific for the human Pro alpha 1(I) collagen chain. Nucleic Acids Res. 10:5925-5934.
24. Melton, D. A., P. A. Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acid Res. 12:7035-7056.
25. Claman, H. N. 1990. Mast cells and fibrosis. Rheum. Dis. Clin. North Am. 16:141-151.
26. Vath, R. R., C. B. Alexander, and J. D. Fulmer. 1982. The lymphocytic infiltrative lung diseases. Clin. Chest Med. 3:619-634.
27. Van Boxel, J. A., and S. A. Paget. 1975. Predominantly T cell infiltrate in rheumatoid synovial membranes. N. Engl. J. Med. 293:517-520.
28. Roumm, A. D., T. L. Whiteside, T. A. Medsger, Jr., and G. P. Rodnan. 1984. Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations. Arthritis Rheum. 6:645-653.
29. Graze, P. R., and R. P. Gale. 1979. Chronic graft versus host disease: a syndrome of disordered immunity. Am. J. Med. 66:611-620.
30. Needleman, B. W., F. M. Wigley, and R. W. Stair. 1991. Interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor a, and interferon γ levels in sera from scleroderma patients. Arthritis Rheum. 35:67-72.