Studies with RP 56976 (taxotere): A semisynthetic analogue of taxol

Journal of the National Cancer Institute

Volumn 83, Issue 4, 1991, Pages 288-291

  Ringel, Israel ^a   Horwitz, Susan Band ^b  

^a HEBREW UNIVERSITY   (Israel)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; DOCETAXEL; GUANOSINE TRIPHOSPHATE; PACLITAXEL;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; HAMSTER; LYMPHATIC LEUKEMIA; METABOLISM; MICROTUBULE; PATHOLOGY; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMAL; CELL SURVIVAL; CELLS, CULTURED; CRICETULUS; GUANOSINE TRIPHOSPHATE; HAMSTERS; LEUKEMIA, LYMPHOCYTIC; MICROTUBULES; PACLITAXEL; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0026428123     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/83.4.288     Document Type: Article

References (20)

1. Schiff PB, Horwitz SB: Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA 77:1561-1565, 1980
2. Schiff PB, Fant J, Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature 277:665-667, 1979
3. Parness J, Horwitz SB: Taxol binds to polymerized tubulin in vitro. J Cell Biol 91:479-487,1981
4. National Cancer Institute: National Cancer Institute Annual Report to the Food and Drug Administration: Taxol (IND 22850, NSC 125973). Bethesda, Md: NCI, 1989
5. Thigpen JT, Blessing JA, Vance RB, et al: Chemotherapy in ovarian carcinoma: Present role and future prospects. Semin Oncol 16(4 suppl 6):58-65, 1989
6. McGuire WP, Rowinsky EK, Rosenshein NB, et al: Taxol: A unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann Intern Med 111:273-279,1989
7. Rowinsky EK, Burke PJ, Karp JE, et al: Phase I and pharmacodynamic study of taxol in refractory acute leukemias. Cancer Res 49:4640-4647,1989
8. Wiernik PH, Schwartz EL, Einzig A, et al: Phase I trial of taxol given as a 24-hour infusion every 21 days: Responses observed in metastatic melanoma. J Clin Oncol 5:1232-1239,1987
9. Denis J-N, Correa A, Greene AE: An improved synthesis of the taxol side chain and of RP 56976. J Org Chem 55:1957-1959, 1990
10. Mangatal L, Adeline MT, Guenard D, et al: Application of the vicinal oxyamination reaction with asymmetric induction to the hemisynthesis of taxol and analogues. Tetrahedron 45:4177-4190,1989
11. Lavelle F, Fizames C, Gueritte-Voegelein F, et al: Experimental properties of RP 56976, a taxol derivative. Proc AACR 30:566, 1989
12. Bissery MC, Bayssas M, Lavelle F: Preclinical evaluation of intravenous taxotere (RP 56976, NSC 628503), a taxol analog. Proc AACR 31:417, 1990
13. Ringel I, Horwitz SB: Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther 242:692-698, 1987
14. Shelanski ML, Gaskin F, Cantor CR: Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci USA 70:765-768,1973
15. Gaskin F, Cantor CR, Shelanski ML: Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules. J Mol Biol 89:737-755, 1974
16. Roy SN, Horwitz SB: A phosphoglycoprotein associated with taxol resistance in J774.2 cells. Cancer Res 45:3856-3863,1985
17. Greenberger LM, Lothstein L, Williams SS, et al: Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc Natl Acad Sci USA 85:3762-3766, 1988
18. Parness J, Kingston DGI, Powell RG, et al: Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes. Biochem Biophys Res Commun 105:1082-1089,1982
19. Swindell CS, Krauss NE, Horwitz SB, et al: Biologically active taxol analogues with deleted A-ring side chain substituents and variable C-2’ configurations. J Med Chem 34, 1991
20. Loike JD, Horwitz SB: Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in Hela cells. Biochemistry 15:5435-5443, 1976