Therapeutic advantage of hypoxic cells in tumors: A theoretical study

Journal of the National Cancer Institute

Volumn 83, Issue 3, 1991, Pages 178-185

  Brown, J Martin ^a   Koong, Albert ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RADIATION SENSITIZING AGENTS; RADIOSENSITIZING AGENT;

ARTICLE; BIOLOGICAL MODEL; CELL HYPOXIA; CELL SURVIVAL; DRUG EFFECT; NEOPLASM; PHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE;

CELL HYPOXIA; CELL SURVIVAL; MODELS, BIOLOGICAL; NEOPLASMS; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026417645     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/83.3.178     Document Type: Article

References (37)

1. MOULDER JE, ROCKWELL S: Hypoxic fractions of solid tumors; Experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10:695-712, 1984
2. ROCKWELL S, MOULDER JE: Hypoxic fractions of human tumors xenografted minto mice: A review. Int J Radiat Oncol Biol Phys 19:197-202, 1990
3. MUELLER-KXIESER W, VAUPEL P, MANZ R, ET AL: Intracapillary oxyhemoglobin saturation of malignant tumors in humans. Int J Radiat Oncol Biol Phys 7:1397-1404, 1981
4. VAUPEL P, KALUNOWSKJ F, OKUNIEFF P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 49:6449-6465, 1989
5. BUSH RS, JENKIN RDT, ALLT WEC, ET AL: Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br J Cancer Suppl 37:302-306, 1978
6. OVERGAARD J, BENTZEN SM, KOLSTAD P, ET AL: Misonidazole combined with radiotherapy in the treatment of carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 16:1069-1072, 1989
7. GATENBY RA, KESSLER HB, ROSENBLUM JS, ET AL: Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14:831-838, 1988
8. HENK JM, SMITH CW: Radiotherapy and byperbaric oxygen in head and neck cancer. Interim report of second clinical trial. Lancet 2:104-105, 1977
9. KENNEDY KA: Hypoxic cells as specific drug targets for chemotherapy. Anticancer Drug Des 2:181-194, 1987
10. TANNOCK I, GUTTMAN P: Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions. Br J Cancer 43:245-248, 1981
11. SARTORELU AC: Therapeutic attack of hypoxic cells of solid tumors: Presidential address. Cancer Res 48:775-778, 1988
12. ROCKWELL S, MATE TP, IRVIN CG, ET AL: Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion. Int J Radiat Oncol Biol Phys 12:1315-1318, 1986
13. TEICHER BA, ROSE CM: Oxygen arrying perfluorochemical emulsion as an adjuvant to radiation therapy in mice. Cancer Res 44:4285-4288, 1984
14. HORSMAN MR, BROWN JM, HIRST VK, ET AL: Mechanism of action of the selective tumor radiosensitizer nicotinamide. Int J Radiat Oncol Biol Phys 15:685-690, 1988
15. HIRST DG, WOOD PJ: Altered radiosensitivity in a mouse carcinoma after administration of dofibrate and bezafibrate. Radiother Oncol 15:55-61, 1989
16. HALL EJ: Radiobiology for the Radiologist, 3rded. Philadelphia: Lippincott, 1988, pp 173-175
17. FOWLER JF: Rationales for high linear energy transfer radiotherapy. In The Biological Basis of Radiotherapy (Steel GG, Adams GE, Peckham MJ, eds). Amsterdam: Elsevier, 1983, pp 261-268
18. ADAMS GE: Hypoxia-mediated drugs for radiation and chemotherapy. Cancer 48:696-707, 1981
19. BROWN JM: Keynote address: Hypoxic cell radiosensitizers: Where next? Int J Radiat Oncol Biol Phys 16:987-993, 1988
20. ROCKWELL S, KENNEDY KA, SARTORELU AC: Mitomycin-C as a prototype bioreductive alkylating agent; In vitro studies of metabolism and cytotoxicity. Int J Radiat Oncol Biol Phys 8:753-755, 1982
21. ZEMAN EM, BROWN JM, LEMMON MJ, ET AL: SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 12:1239-1242, 1986
22. KALLMAN RF: The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology 105:135-142, 1972
23. FERTIL B, MALAISE EP: Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors; Analysis of 101 published survival curves. Int J Radiat Oncol Biol Phys 11:1699-1707, 1985
24. COLEMAN CN, WASSERMAN TH, URTASUN RC, ET AL: Phase I trial of the hypoxic cell radiosensitizer SR-2508: The results of the five to six week drug schedule. Int J Radiat Oncol Biol Phys 12:1105-1108, 1986
25. DISCHE S: Radiotherapy using the hypoxic cell sensitizer Ro 03-8799 in malignant melanoma. Radiother Oncol 10:111-116, 1987
26. BROWN JM, LEMMON MJ: Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Resn 50:7745-7749, 1990
27. BROCK WA, BAKER FL, WiKE JL, ETAL:Cellularradiosensitivity of primary head and neck squamous cell carcinomas and local tumor control. Int J Radiat Oncol Biol Phys 18:1283-1286, 1990
28. GUICHARD M, DERTINGER H, MALAISE EP: Radiosensitivity of four human tumor xenografts. Influence of hypoxia and cell-cell contact Radiat Res 95:602-609, 1983
29. SUN JR, BROWN JM: Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. Cancer Res 49:5664-5670, 1989
30. CHAPLIN DJ: Potentiation of RSU-1069 tumour cytotoxicity by 5-hydroxytryptamine (5-HT). Br J Cancer 54:727-731, 1986
31. CHAPLIN DJ, ACKER B: The effect ofhydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: Evidence for therapeutic gain. Int J Radiat Oncol Biol Phys 13:579-585, 1987
32. BROWN JM: Exploitation of bioreductive agents with vasoaetive drugs. In Proceedings of the 8th International Congress of Radiation Research, vol 2. London: Taylor & Francis, 1987, pp 719-724
33. WEISSBERG JB, SON YH, PAPAC RJ, ET AL: Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer. Int J Radiat Oncol Biol Phys 17:3-9, 1989
34. ELKJND MM, WHITMORE GF: The Radiobiology of Cultured Mammalianb Cells. New York: Gordon & Breach, 1967, pp 9-17
35. HALL EJ: Radiobiology for the Radiologist, 3rd ed. Philadelphia: lippincott, 1988, pp 20-26
36. PALCIC B, SKARSGARD LD:Reduredoxygen enhancement ratio at low doses of ionizing radiation. Radiat Res 100: 328-339, 1984
37. BROWN JM, NK:Radiosensitization of hypoxic cells in vivo by SR2508 at low radiation doses: A preliminary report Int J Radiat Oncol Biol Phys 10: 1207-1212, 1984