Three-Step Monoclonal Antibody Tumor Targeting in Carcinoembryonic Antigenpositive Patients

Cancer Research

Volumn 51, Issue 21, 1991, Pages 5960-5966

  Paganelli, G ^a,d   Malcovati, M ^a   Siccardi, A G ^a   Villa, E ^a   Sudati, F ^a   Rossetti, C ^a   Fazio, F ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Società Prodotti Antibiotici   (Italy)

^c Cyberonics Inc   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AVIDIN; BIOTIN; CARCINOEMBRYONIC ANTIGEN; INDIUM 111; MONOCLONAL ANTIBODY; STREPTAVIDIN;

ANTIBODY LABELING; ARTICLE; CANCER PATIENT; CLINICAL ARTICLE; DRUG TARGETING; HUMAN; IMMUNOSCINTIGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; CARCINOEMBRYONIC ANTIGEN; FEMALE; HUMAN; IMMUNOGLOBULIN G; INDIUM RADIOISOTOPES; KIDNEY; LIVER; LIVER NEOPLASMS; NEOPLASMS; RADIOIMMUNODETECTION; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION;

EID: 0026356523     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Goldenberg, D. M., Kim, E. E., DeLand, F. H., Bennet, S., and Primus, F. J. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res., 40: 2984-2992, 1980.
2. Mach, J. P., Buchegger, F., Fomi, M., Buchegge, F., Ritschar, J., Berche, C., Lumbroso, J. D., Schreyer, M., Girardet, C., Accolla, R. S., and Carrel, S. Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinoma by external photoscanning and tomoscintigraphy. Immunol. Today, 2:239-249, 1981.
3. Epenetos, A. A., Britton, K. E., Mather, S., Shepherd, J., Granowska, M., Taylor-Papadimitriou, J., Nimmon, C. C., Durbin, M., Hawkins, L. R., Malpas, J. S., and Bodmer, W. S. Targeting of iodine-123-labelled tumor associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumors. Lancet, 2:999-1004, 1982.
4. Larson, M. S. Radiolabelled monoclonal anti-tumor antibodies in diagnosis and therapy. J. Nucl. Med., 26:538-545, 1985.
5. Buraggi, G. L., Callegaro, L., Mariani, G., Turrin, A., Cascinelli, N., Attili, A., Bombardieri, E., Temo, G., and Plassio, G. Imaging with l3lI-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F(ab')2 fragments. Cancer Res., 45:3378-3387, 1985.
6. Carasquillo, J. A., Krohn, K. A., and Beaumier, P. Diagnosis of and therapy for solid tumors with radiolabeled antibodies and immune fragments. Cancer Treat. Rev., 68:371-378, 1984.
7. Courtenay-Luck, N., Epenetos, A. A., Moore, R., Larche, M., Pectasides, D., Dhokia, B., and Ritter, M. A. Development of primary and secondary immune response to mouse monoclonal antibodies used in the diagnosis and therapy of malignant neoplasm. Cancer Res., 46:6489-6493, 1986.
8. Goodwin, D. A. Pharmacokinetics and antibodies. J. Nucl. Med., 28:1358-1362, 1987.
9. Ott, R. J., Grey, L. J., Zivanoic, M. A., Floker, M. A., Trott, N. G., Moschakis, V., Coombes, R. C., Neville, A. N., Omerod, M. G., and Westwood, J. H. The limitations of the dual radionuclide subtraction technique for the external detection of tumor by radioiodine-labeled antibodies. Br. J. Radiol., 56:101-108, 1983.
10. Begent, R. H. J., Green, A. J., Bagshawe, K. D., Jones, B. E., Keep, P. A., Searle, F., Jewkes, R. F., Barrat, G. M., and Ryman, B. E. Liposomally entrapped second antibody improves tumor imaging with radiolabelled (first) antitumor antibody. Lancet, 2:739-742, 1982.
11. Bradwell, A. R., Vaughn, A., Fairweather, D. S., and Dykes, P. W. Improved radioimmunodetection of tumors using second antibody. Lancet, 1:247-252, 1983.
12. DeLand, F. H., Kim, E. E., and Goldenberg, D. M. Lymphoscintigraphy with radionuclide-labeled antibodies to carcinoembryonic antigen. Cancer Res., 40:2997-3000, 1980.
13. Paganelli, G., Riva, P., Moscatelli, G., Stacchiotti, A., Agostini, M. E., Landi, G., Tison, V., Panacea, P., and Siccardi, A. G. Improved immuno scintigraphy by subcutaneous injection of 9*”Tc-or 11'In-labelled F(ab')2 fragments of an anti-melanoma monoclonal antibody. Int. J. Nucl. Med. Biol., 75:423-428, 1986.
14. Rowlinson, G., Snook, D., Busza, A., and Epenetos, A. A. Antibody-guided localization of intraperitoneal tumors following intraperitoneal or intravenous antibody administration. Cancer Res., 47:6528-6531, 1987.
15. Stickney, D. R., Slater, J. B., Kirk, G. A., Merchant, B., Schweighardt, S. A., and Frincke, J. M. A bifunctional antibody delivery system: clinical studies demonstrate imaging and therapeutic potential. J. Nucl. Med., 31: 734, 1990.
16. Hnatowich, D. J., Virzi, F., and Rusckowski, M. Investigations of avidin and biotin for imaging applications. J. Nucl. Med., 28:1294-1302, 1987.
17. Paganelli, G., Riva, P., Deleide, G., Clivio, A., Chiolerio, F., Scassellati, G. A., Malcovati, M., and Skcardi, A. G. In vivo labelling of biotinylated monoclonal antibodies by radioactive avidin: a strategy to increase tumor radiolocalization. Int. J. Cancer, 2 (Suppl.); 121-125, 1988.
18. Le Doussal, J. M., Martin, M., Gautherot, E., Delaage, M., and Barbet, J. In vitro and in vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate. J. Nucl. Med., 30: 1358-1366, 1989.
19. Goodwin, D. A., Meares, C. F., McCall, M. J., McTigue, M., and Chaovapong, W. Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens. J. Nucl. Med., 29:226-234, 1988.
20. Paganelli, G., Pervez, S., Siccardi, A. G., Rowlinson, G., Deleide, G., Chiolerio, F., Malcovati, M., Scassellati, G. A., and Epenetos, A. A. Intraperitoneal radio-localization of tumors pre-targeted by biotinylated monoclonal antibodies. Int. J. Cancer, 45:1184-1189, 1990.
21. Oehr, P., Westermann, J., and Biersack, H. J. Streptavidin and biotin as potential tumor imaging agents. J. Nucl. Med., 29:728-729, 1988.
22. Sinitsyn, V. V., Mamontova, A. G., Checkneva, Y. Y., Shnyra, A. A., and Domogatsky, S. P. Rapid blood clearance of biotinylated IgG after infusion of avidin. J. Nucl. Med., 30:66-69,1989.
23. Green, N. M. Avidin-1. The use of [14C]biotin for kinetic studies and for assay. Biochem. J., 89:585-591, 1963.
24. Green, N. M. Avidin. Adv. Protein Chem., 29:85-133, 1975.
25. Green, N. M. A spectrophotometric assay for avidin and biotin based on binding of dyes by avidin. Biochem. J., 94:23c, 1965.
26. Wikhek, M., and Bayer, E. A. The avidin-biotin complex in immunology. Immunol. Today, 5: 39-43,1984.
27. Wilchek, M., and Bayer, E. A. The avidin-biotin complex in bioanalytical applications. Anal. Biochem., 171:1-32,1988.
28. Rowlinson, G., Rusckowski, M., Gionet, M., Siebecker, D., Snook, D., Epenetos, A. A., and Hnatowich, D. J. Animal tumor localization studies with streptavidin conjugated antibody and labelled biotin. J. Nucl. Med., 29: 762, 1988.
29. Kalofonos, H. P., Rusckowski, M., Siebecker, D. A., Sivolapenko, G. B., Snook, D., Lavender, J. P., Epenetos, A. A., and Hnatowich, D. J. Imaging of tumor in patients with Indium-111-labeled biotin and streptavidin-coiyu-gated antibodies: preliminary communication. J. Nucl. Med., 31:1791-1796, 1990.
30. Buraggi, G. L., Callegaro, L., Turrin, A., Gennari, L., Bombardieri, E., Mariani, G., Deleide, G., Dovis, M., Gasparini, M., Doci, R., Regalia, E., Seregni, E., and Scassellati, G. A. Immunoscintigraphy of colorectal carcinoma with F(ab'2 fragments of anti-CEA monoclonal antibody. Cancer Detect. Prev., 10:335-345, 1987.
31. Gasparini, M., Ripamonti, M., Seregni, E., Regalia, E., and Buraggi, G. L. Tumor imaging of colo-rectal carcinoma with an anti-CEA monoclonal antibody. Int. J. Cancer, 2 (Suppl.); 81-84, 1988.
32. Siccardi, A. G., Buraggi, G. L., Callegaro, L., Centi Colella, A., De Filippi, P. G., Galli, G., Mariani, G., Masi, R., Palumbo, R., Riva, P., Salvatore, M., Scassellati, G. A., Scheidhaurer, K., Turco, G. L., Zaniol, P., Benini, S., Deleide, G., Gasparini, M., Lastoria, S., Mansi, L., Paganelli, G., Salvischi-ani, E., Seregni, E., Viale, G., and Natali, P. G. Immunoscintigraphy of adenocarcinomas by means of radiolabeled F(ab')a fragments of an anti-carcinoembryonic antigen monoclonal antibody: a multicenter study. Cancer Res., 49:3095-3103, 1989.
33. Rowlinson, G., Paganelli, G., Snook, D., and Epenetos, A. A. Radiolocalization of an anti-CEA monoclonal antibody (F023C5) and its fragments in a colon carcinoma xenograft model. Int. J. Biol. Markers, 3:259-264, 1988.
34. Seccamani, E., Tattanelli, M., Mariani, M., Spranzi, E., Scassellati, G. A., and Siccardi, A. G. A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples. Nucl. Med. Biol., 2:167-170, 1989.
35. Paganelli, G., De Nardi, P., Magnani, P., Stella, M., Pennacchioli, L., Di Carlo, V., Fazio, F., and Siccardi, A. G. Antibody guided surgery in cancer patients: rapid blood clearance using 1-125 labelled biotinylated monoclonal antibodies and cold avidin. J. Nucl. Med., 31:853, 1990.
36. Ferrant, A., and Cauwe, F. Quantitative organ uptake measurement with a gamma camera. Eur. J. Nucl. Med., 4:223-229, 1979.
37. Wicks, R., Rosenspire, K., Ackerhalt, R., Langan, M., Steinbach, J. J., and Blau, M. Distribution of Tc-99m administered as labeled microsphere for lung imaging. In: Third International Radiation Dosage Symposium. FDA 81/8166. Rockville, MD: U. S. Food and Drug Administration, 1981.
38. Myres, M. J., Lavender, J. P., De Oliveira, G. B., and Maseri, A. A simplified method of quantitated organ uptake using a gamma camera. Br. J. Radiol., 54:1062-1067, 1981.
39. Snyder, W. S., Ford, M. R., Warner, G. G., and Watson, S. B. “S” absorbed dose per unit cumulated activity for selected radionuclides and organs. MIRD Pamphlet No. 11. New York: Society of Nuclear Medicine, 1975.
40. Paganelli, G., Malcovati, M., and Fazio, F. Monoclonal antibody pretargetting techniques for tumour localization: the avidin-biotin system. Nucl. Med. Commun., 12: 211-234, 1991.
41. Su-Ming, H. S. U., Raine, L., and Fanger, H. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem., 29:577-580, 1981.
42. Su-Ming, H. S. U., Raine, L., and Fanger, H. A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am. J. Clin. Pathol., 75:734-738, 1981.
43. Epenetos, A. A., Snook, D., Durbin, H., Johnson, P. M., and Taylor-Papadimitriou, J. Limitations of radiolabeled monoclonal antibodies for localization of human neoplasm. Cancer Res., 46: 3183-3191, 1986.
44. Natali, P. G., Bigotti, A., Cavaliere, R., Liao, S. K., Taniguchi, M., Matsui, M., and Ferrone, S. Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma. Cancer Res., 45:2882-2889, 1985.
45. Munz, D. L., Alavi, A., Koprowsky, H., and Herlyn, D. Improved radioimmunoimaging of human tumor xenografts by a mixture of monoclonal antibody F(ab/>2 fragments. J. Nucl. Med., 27:1739-1745, 1986.