The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood

American Journal of Obstetrics and Gynecology

Volumn 165, Issue 6 PART 1, 1991, Pages 1695-1700

  Wang, Yuping ^a,b   Walsh, Scott W ^a   Guo, Jingde ^b   Zhang, Junyan ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Lipid peroxides; preeclampsia; prostacyclin; thromboxane; vitamin E

Indexed keywords

ALPHA TOCOPHEROL; LIPID PEROXIDE; PROSTACYCLIN; THROMBOXANE;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; NORMAL HUMAN; PREECLAMPSIA; PRIORITY JOURNAL;

6-KETOPROSTAGLANDIN F1 ALPHA; FEMALE; HUMAN; LIPID PEROXIDES; PRE-ECLAMPSIA; PREGNANCY; SUPPORT, U.S. GOV'T, P.H.S.; THROMBOXANE B2; VITAMIN E;

EID: 0026354326     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/0002-9378(91)90017-L     Document Type: Article

References (28)

1. Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy
2. Preeclampsia: an imbalance in placental prostacyclin and thromboxane production
3. Tocopherol stabilizes membrane against phospholipase A, free fatty acids, and lysophospholipids
4. Peroxidation of fatty acids
5. Lipid peroxidation and endothelial cell injury: implications in atherosclerosis
6. Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells
7. Lipid peroxidation in pregnancy new perspectives on preeclampsia
8. Lipid peroxides are potential mediators of vasospasm in pregnancy-induced hypertension (PIH) [Abstract 91]
9. Lipid peroxidation and altered vascular function in vitamin E-deficient rats
10. Lipid peroxidation in relation to prostacyclin and thromboxane physiology and pathophysiology
11. Effect of hyperlipidemic serum on lipid peroxidation synthesis of prostacyclin and thromboxane by cultured endothelial cells protective effect of antioxidants
12. Effect of hydrogen peroxide on prostaglandin production and cellular integrity in cultured porcine aortic endothelial cells
13. Assay for serum lipid peroxide level and its clinical significance
14. Fluorometric determination of tocopherol in serum
15. Effects of lipid peroxides on prostacyclin and thromboxane generation in hypercholesterolemic rabbits
16. Physiology of low-dose aspirin therapy for the prevention of preeclampsia
17. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced,hypertension
18. Studies on lipoperoxide of normal pregnant women and of patients with toxemia of pregnancy
19. Free-radical oxidation (peroxidation) products in plasma in normal and abnormal pregnancy
20. Prostaglandin synthesis and lipid peroxidation in pregnant patients with gestosis
21. Plasma retinol, β-carotene and vitamin E levels in relation to the future risk of preeclampsia
22. Preeclamptic sera does not demonstrate the marked increase in antioxidant activity observed in normal pregnant sera [Abstract 7]
23. Plasma tocopherol and lipid levels in pregnancy and oral contraceptive users
24. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH
25. Lipid and glucose metabolism in human placental culture
26. Increased free radical activity in pregnant women with EPH-gestose
27. Antioxidative drugs as a part of combined therapy in patients with late gestoses
28. Prevention of preeclampsia: pathophysiological rationale for the use of low-dose aspirin