메뉴 건너뛰기




Volumn 20, Issue 4, 1991, Pages 807-823

Insulin as an effector of human ovarian and adrenal steroid metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; DIAZOXIDE; FOLLITROPIN; INSULIN; LEUPRORELIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; TESTOSTERONE;

EID: 0026353647     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0889-8529(18)30245-7     Document Type: Review
Times cited : (129)

References (93)
  • 1
    • 0016241117 scopus 로고
    • Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle
    • Abraham G.E. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle J Clin Endocrinol Metab 39 1974 340
    • (1974) J Clin Endocrinol Metab , vol.39 , pp. 340
    • Abraham, G.E.1
  • 2
    • 0020065783 scopus 로고
    • Insulin augmentation of testosterone production in a primary culture of rat testicular cells
    • Adashi E.Y. Fabrics C. Hsueh A.J.W. Insulin augmentation of testosterone production in a primary culture of rat testicular cells Biol Reprod 26 1982 270
    • (1982) Biol Reprod , vol.26 , pp. 270
    • Adashi, E.Y.1    Fabrics, C.2    Hsueh, A.J.W.3
  • 3
    • 0020627140 scopus 로고
    • Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features
    • Barbieri R.L. Ryan K.J. Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features Am J Obstet Gynecol 147 1983 90
    • (1983) Am J Obstet Gynecol , vol.147 , pp. 90
    • Barbieri, R.L.1    Ryan, K.J.2
  • 4
    • 0022647650 scopus 로고
    • Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism
    • Barbieri R.L. Makris A. Randall R.W. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism J Clin Endocrinol Metab 62 1986 904
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 904
    • Barbieri, R.L.1    Makris, A.2    Randall, R.W.3
  • 5
    • 0023713274 scopus 로고
    • The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism
    • Barbieri R.L. Smith S. Ryan K.J. The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism Fertil Steril 50 1988 197
    • (1988) Fertil Steril , vol.50 , pp. 197
    • Barbieri, R.L.1    Smith, S.2    Ryan, K.J.3
  • 7
    • 0024602863 scopus 로고
    • Pituitary-ovarian responses to nafarelin in the polycystic ovary syndrome
    • Barnes R.B. Rosenfield R.L. Burstein S. Pituitary-ovarian responses to nafarelin in the polycystic ovary syndrome N Engl J Med 320 1989 559
    • (1989) N Engl J Med , vol.320 , pp. 559
    • Barnes, R.B.1    Rosenfield, R.L.2    Burstein, S.3
  • 8
    • 0019993445 scopus 로고
    • Effect of body weight reduction on plasma androgens in obese, infertile women
    • Bates G.W. Whitworth N.S. Effect of body weight reduction on plasma androgens in obese, infertile women Fertil Steril 38 1982 406
    • (1982) Fertil Steril , vol.38 , pp. 406
    • Bates, G.W.1    Whitworth, N.S.2
  • 9
    • 0023215674 scopus 로고
    • Diurnal rhythm of growth hormone—independent binding protein for insulin-like growth factors in human plasma
    • Baxter R.C. Cowell C.T. Diurnal rhythm of growth hormone—independent binding protein for insulin-like growth factors in human plasma J Clin Endocrinol Metab 62 1987 432
    • (1987) J Clin Endocrinol Metab , vol.62 , pp. 432
    • Baxter, R.C.1    Cowell, C.T.2
  • 10
    • 0019439379 scopus 로고
    • The effect of insulin and luteinizing hormone treatment on serum concentrations of testosterone and dihydrotestosterone and testicular 3β-hydroxysteroid dehydrogenase activity in intact and hypophysectomized diabetic rats
    • Blanco F.L. Fanjul L.F. Ruiz de Galarreta C.M. The effect of insulin and luteinizing hormone treatment on serum concentrations of testosterone and dihydrotestosterone and testicular 3β-hydroxysteroid dehydrogenase activity in intact and hypophysectomized diabetic rats Endocrinology 109 1981 1248
    • (1981) Endocrinology , vol.109 , pp. 1248
    • Blanco, F.L.1    Fanjul, L.F.2    Ruiz de Galarreta, C.M.3
  • 11
    • 0024954552 scopus 로고
    • The nature and function of polypeptide growth factor receptors in the human placenta
    • Blay J. Hollenberg M.D. The nature and function of polypeptide growth factor receptors in the human placenta J Dev Physiol 12 1989 237
    • (1989) J Dev Physiol , vol.12 , pp. 237
    • Blay, J.1    Hollenberg, M.D.2
  • 12
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease
    • Burghen G.A. Givens J.R. Kitabchi A.E. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease J Clin Endocrinol Metab 50 1980 113
    • (1980) J Clin Endocrinol Metab , vol.50 , pp. 113
    • Burghen, G.A.1    Givens, J.R.2    Kitabchi, A.E.3
  • 13
    • 0023772227 scopus 로고
    • Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells
    • Cara J.F. Rosenfield R.L. Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells Endocrinology 123 1988 733
    • (1988) Endocrinology , vol.123 , pp. 733
    • Cara, J.F.1    Rosenfield, R.L.2
  • 14
    • 0024996150 scopus 로고
    • Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells
    • Cara J.F. Fan J. Azzarello J. Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells J Clin Invest 86 1990 560
    • (1990) J Clin Invest , vol.86 , pp. 560
    • Cara, J.F.1    Fan, J.2    Azzarello, J.3
  • 15
    • 0020635004 scopus 로고
    • Insulin resistance in nonobese patients with polycystic ovarian disease
    • Chang R.J. Nakaruma R.M. Judd H.L. Insulin resistance in nonobese patients with polycystic ovarian disease J Clin Endocrinol Metab 57 1983 356
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 356
    • Chang, R.J.1    Nakaruma, R.M.2    Judd, H.L.3
  • 16
    • 0025341834 scopus 로고
    • Insulin regulation of insulin-like growth factor-binding protein production in cultured HepG2 cells
    • Conover C.A. Lee P.D.K. Insulin regulation of insulin-like growth factor-binding protein production in cultured HepG2 cells J Clin Endocrinol Metab 70 1990 1062
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1062
    • Conover, C.A.1    Lee, P.D.K.2
  • 17
    • 0025771972 scopus 로고
    • Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women
    • Diamond M.P. Grainger D. Laudino A.J. Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women J Clin Endocrinol Metab 72 1991 883
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 883
    • Diamond, M.P.1    Grainger, D.2    Laudino, A.J.3
  • 18
    • 0023835915 scopus 로고
    • The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome
    • Dunaif A. Mandeli J. Fluhr H. The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome J Clin Endocrinol Metab 66 1988 131
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 131
    • Dunaif, A.1    Mandeli, J.2    Fluhr, H.3
  • 19
    • 0024590991 scopus 로고
    • Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin resistant women with the polycystic ovary syndrome
    • Dunaif A. Graf M. Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin resistant women with the polycystic ovary syndrome J Clin Invest 83 1989 23
    • (1989) J Clin Invest , vol.83 , pp. 23
    • Dunaif, A.1    Graf, M.2
  • 20
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A. Segal K.R. Futterweit W. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome Diabetes 38 1989 1165
    • (1989) Diabetes , vol.38 , pp. 1165
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3
  • 21
    • 0025359669 scopus 로고
    • Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome
    • Dunaif A. Green G. Futterweit W. Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome J Clin Endocrinol Metab 70 1990 699
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 699
    • Dunaif, A.1    Green, G.2    Futterweit, W.3
  • 22
    • 0025341827 scopus 로고
    • The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries
    • Erickson G.F. Magoffin D.A. Cragun J.R. The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries J Clin Endocrinol Metab 70 1990 894
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 894
    • Erickson, G.F.1    Magoffin, D.A.2    Cragun, J.R.3
  • 23
    • 0025667314 scopus 로고
    • Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women
    • Falcone T. Finegood D.T. Fantus G. Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women J Clin Endocrinol Metab 71 1990 1653
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1653
    • Falcone, T.1    Finegood, D.T.2    Fantus, G.3
  • 24
    • 0025275487 scopus 로고
    • Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: Positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans
    • Farah M.J. Givens J.R. Kitabchi A.E. Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: Positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans J Clin Endocrinol Metab 70 1990 1075
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1075
    • Farah, M.J.1    Givens, J.R.2    Kitabchi, A.E.3
  • 25
    • 0022001970 scopus 로고
    • Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the Type A and B syndromes
    • Flier J.S. Eastman R.C. Minaker K.L. Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the Type A and B syndromes Diabetes 34 1985 101
    • (1985) Diabetes , vol.34 , pp. 101
    • Flier, J.S.1    Eastman, R.C.2    Minaker, K.L.3
  • 26
    • 0021337501 scopus 로고
    • Aromatase activity in human granulosa cells during follicular development and the modulation of follicle-stimulating hormone and insulin
    • Garzo V.G. Dorrington J.H. Aromatase activity in human granulosa cells during follicular development and the modulation of follicle-stimulating hormone and insulin Am J Obstet Gynecol 148 1984 657
    • (1984) Am J Obstet Gynecol , vol.148 , pp. 657
    • Garzo, V.G.1    Dorrington, J.H.2
  • 27
    • 0023609505 scopus 로고
    • Characterization of insulin-like growth factor I binding to human granulosa cells obtained during in vitro fertilization
    • Gates G.S. Bayer S. Seibel M. Characterization of insulin-like growth factor I binding to human granulosa cells obtained during in vitro fertilization J Recept Res 7 1987 885
    • (1987) J Recept Res , vol.7 , pp. 885
    • Gates, G.S.1    Bayer, S.2    Seibel, M.3
  • 28
    • 0022625803 scopus 로고
    • Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion
    • Geffner M.E. Kaplan S.A. Bersch N. Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion Fertil Steril 45 1986 327
    • (1986) Fertil Steril , vol.45 , pp. 327
    • Geffner, M.E.1    Kaplan, S.A.2    Bersch, N.3
  • 31
    • 0024852228 scopus 로고
    • The effect of the insulin mediator on the metabolism of androst-4-ene-3,17-dione in isolated rat hepatocytes
    • Gulati P. Skett P. The effect of the insulin mediator on the metabolism of androst-4-ene-3,17-dione in isolated rat hepatocytes Biochem Pharmacol 38 1989 4415
    • (1989) Biochem Pharmacol , vol.38 , pp. 4415
    • Gulati, P.1    Skett, P.2
  • 32
    • 0023897058 scopus 로고
    • The relationship of sex hormones to hyperinsulinemia and hyperglycemia
    • Haffner S.M. Katz M.S. Stern M.P. The relationship of sex hormones to hyperinsulinemia and hyperglycemia Metabolism 37 1988 683
    • (1988) Metabolism , vol.37 , pp. 683
    • Haffner, S.M.1    Katz, M.S.2    Stern, M.P.3
  • 33
    • 0021611961 scopus 로고
    • Weight loss is associated with correction of gonadotropin and sex steroid abnormalities in the obese anovulatory female
    • Harlass F.E. Plymate S.R. Fariss B.L. Weight loss is associated with correction of gonadotropin and sex steroid abnormalities in the obese anovulatory female Fertil Steril 42 1984 649
    • (1984) Fertil Steril , vol.42 , pp. 649
    • Harlass, F.E.1    Plymate, S.R.2    Fariss, B.L.3
  • 34
    • 0023949583 scopus 로고
    • Somatomedin-C/insulin-like growth factor I as an enhancer of androgen biosynthesis by cultured rat ovarian cells
    • Hernandez E.R. Resnick C.E. Svoboda M.E. Somatomedin-C/insulin-like growth factor I as an enhancer of androgen biosynthesis by cultured rat ovarian cells Endocrinology 122 1988 1603
    • (1988) Endocrinology , vol.122 , pp. 1603
    • Hernandez, E.R.1    Resnick, C.E.2    Svoboda, M.E.3
  • 35
    • 85112984233 scopus 로고    scopus 로고
    • Hubert GD, Schriock ED, Givens JR, et al: Insulin suppression of adrenal androgen concentrations during glucose tolerance testing in normal women [abstract 31]. In Scientific Program and Abstracts for the 37th Annual Meeting of the Society for Gynecologic Investigation, 1990, p 112
  • 36
    • 0023630508 scopus 로고
    • The effect of insulin on steroid metabolism in isolated rat hepatocytes
    • Hussin A.H. Skett P. The effect of insulin on steroid metabolism in isolated rat hepatocytes Biochem Pharmacol 36 1987 3155
    • (1987) Biochem Pharmacol , vol.36 , pp. 3155
    • Hussin, A.H.1    Skett, P.2
  • 37
    • 0017900194 scopus 로고
    • Primary amenorrhea associated with hirsutism, acanthosis nigricans, dermoid cysts of the ovaries and a new type of insulin resistance
    • Imperato-McGinley J. Peterson R.E. Sturla E. Primary amenorrhea associated with hirsutism, acanthosis nigricans, dermoid cysts of the ovaries and a new type of insulin resistance Am J Med 65 1978 389
    • (1978) Am J Med , vol.65 , pp. 389
    • Imperato-McGinley, J.1    Peterson, R.E.2    Sturla, E.3
  • 39
    • 0017154704 scopus 로고
    • The syndrome of insulin resistance and acanthosis nigricans
    • Kahn C.R. Flier J.S. Bar R.S. The syndrome of insulin resistance and acanthosis nigricans N Engl J Med 294 1976 739
    • (1976) N Engl J Med , vol.294 , pp. 739
    • Kahn, C.R.1    Flier, J.S.2    Bar, R.S.3
  • 40
    • 0025092087 scopus 로고
    • Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: An analysis of 263 consecutive cases
    • Kiddy D.S. Sharp P.S. White D.M. Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: An analysis of 263 consecutive cases Clin Endocrinol (Oxf) 32 1990 213
    • (1990) Clin Endocrinol (Oxf) , vol.32 , pp. 213
    • Kiddy, D.S.1    Sharp, P.S.2    White, D.M.3
  • 41
    • 0025349661 scopus 로고
    • Human granulosa cells contain insulin-like growth factor-binding protein (IGF BP-1) mRNA
    • Koistinen R. Suikkari A.-M. Tiitinen A. Human granulosa cells contain insulin-like growth factor-binding protein (IGF BP-1) mRNA Clin Endocrinol (Oxf) 32 1990 635
    • (1990) Clin Endocrinol (Oxf) , vol.32 , pp. 635
    • Koistinen, R.1    Suikkari, A.-M.2    Tiitinen, A.3
  • 42
    • 0025371902 scopus 로고
    • Differential modulation of ACTH-stimulated cortisol and androstenedione secretion by insulin
    • Kramer R.E. Buster J.E. Andersen R.N. Differential modulation of ACTH-stimulated cortisol and androstenedione secretion by insulin J Steroid Biochem 36 1990 33
    • (1990) J Steroid Biochem , vol.36 , pp. 33
    • Kramer, R.E.1    Buster, J.E.2    Andersen, R.N.3
  • 43
    • 0025079183 scopus 로고
    • Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: Evidence for a reduced 17,20-desmolase enzymatic activity
    • Liu C.H. Laughlin G.A. Fischer U.G. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: Evidence for a reduced 17,20-desmolase enzymatic activity J Clin Endocrinol Metab 71 1990 900
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 900
    • Liu, C.H.1    Laughlin, G.A.2    Fischer, U.G.3
  • 45
    • 0023691401 scopus 로고
    • Androgen levels during sequential insulin euglycemic clamp studies in patients with polycystic ovary disease
    • Micic D. Popovic V. Nesovic M. Androgen levels during sequential insulin euglycemic clamp studies in patients with polycystic ovary disease J Steroid Biochem 31 1988 995
    • (1988) J Steroid Biochem , vol.31 , pp. 995
    • Micic, D.1    Popovic, V.2    Nesovic, M.3
  • 46
    • 84965028377 scopus 로고
    • Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex; day-to-day and diurnal variations
    • Migeon C.J. Keller A.R. Lawrence B. Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex; day-to-day and diurnal variations J Clin Endocrinol Metab 17 1957 1051
    • (1957) J Clin Endocrinol Metab , vol.17 , pp. 1051
    • Migeon, C.J.1    Keller, A.R.2    Lawrence, B.3
  • 47
    • 0024272188 scopus 로고
    • Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (Type A insulin resistance)
    • Möller D.E. Flier J.S. Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (Type A insulin resistance) N Engl J Med 319 1988 1526
    • (1988) N Engl J Med , vol.319 , pp. 1526
    • Möller, D.E.1    Flier, J.S.2
  • 48
    • 0024336529 scopus 로고
    • Insulin enhances luteinizing hormone-stimulated steroidogenesis by porcine theca cells
    • Morley P. Calaresu F.R. Barbe G.J. Insulin enhances luteinizing hormone-stimulated steroidogenesis by porcine theca cells Biol Reprod 40 1989 735
    • (1989) Biol Reprod , vol.40 , pp. 735
    • Morley, P.1    Calaresu, F.R.2    Barbe, G.J.3
  • 50
    • 0023545220 scopus 로고
    • Modulation of aromatase and P450 cholesterol side-chain cleavage enzyme activities of human placental cytotrophoblasts by insulin and insulin-like growth factor I
    • Nestler J.E. Modulation of aromatase and P450 cholesterol side-chain cleavage enzyme activities of human placental cytotrophoblasts by insulin and insulin-like growth factor I Endocrinology 121 1987 1845
    • (1987) Endocrinology , vol.121 , pp. 1845
    • Nestler, J.E.1
  • 51
    • 0023102652 scopus 로고
    • The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans
    • Nestler J.E. Clore J.N. Strauss J.F. III The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans J Clin Endocrinol Metab 64 1987 180
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 180
    • Nestler, J.E.1    Clore, J.N.2    Strauss, J.F.3
  • 52
    • 0024439558 scopus 로고
    • Insulin and insulin-like growth factor I stimulate the 3β-hydroxysteroid dehydrogenase activity of human placental cytotrophoblasts
    • Nestler J.E. Insulin and insulin-like growth factor I stimulate the 3β-hydroxysteroid dehydrogenase activity of human placental cytotrophoblasts Endocrinology 125 1989 2127
    • (1989) Endocrinology , vol.125 , pp. 2127
    • Nestler, J.E.1
  • 53
    • 0024355532 scopus 로고
    • The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome
    • Nestler J.E. Clore J.N. Blackard W.G. The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome Am J Obstet Gynecol 161 1989 1095
    • (1989) Am J Obstet Gynecol , vol.161 , pp. 1095
    • Nestler, J.E.1    Clore, J.N.2    Blackard, W.G.3
  • 54
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome
    • Nestler J.E. Barlascini C.O. Matt D.W. Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome J Clin Endocrinol Metab 68 1989 1027
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 1027
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 55
    • 0024470186 scopus 로고
    • Suppression of serum dehydroepiandroster one sulfate levels by insulin: An evaluation of possible mechanisms
    • Nestler J.E. Usiskin K.S. Barlascini C.O. Suppression of serum dehydroepiandroster one sulfate levels by insulin: An evaluation of possible mechanisms J Clin Endocrinol Metab 69 1989 1040
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 1040
    • Nestler, J.E.1    Usiskin, K.S.2    Barlascini, C.O.3
  • 56
    • 0025038730 scopus 로고
    • Increased transcapillary escape rate of albumin in nondiabetic men in response to hyperinsulinemia
    • Nestler J.E. Barlascini C.O. Tetrault G.A. Increased transcapillary escape rate of albumin in nondiabetic men in response to hyperinsulinemia Diabetes 39 1990 1212
    • (1990) Diabetes , vol.39 , pp. 1212
    • Nestler, J.E.1    Barlascini, C.O.2    Tetrault, G.A.3
  • 57
    • 0025123930 scopus 로고
    • Suppression of serum insulin by diazoxide does not alter serum testosterone or sex hormone-binding globulin levels in healthy nonobese women
    • Nestler J.E. Singh R. Matt D.W. Suppression of serum insulin by diazoxide does not alter serum testosterone or sex hormone-binding globulin levels in healthy nonobese women Am J Obstet Gynecol 163 1990 1243
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 1243
    • Nestler, J.E.1    Singh, R.2    Matt, D.W.3
  • 58
    • 0026028184 scopus 로고
    • A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome
    • Nestler J.E. Powers L.P. Matt D.W. A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome J Clin Endocrinol Metab 72 1991 83
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 83
    • Nestler, J.E.1    Powers, L.P.2    Matt, D.W.3
  • 59
    • 85112968625 scopus 로고    scopus 로고
    • Nestler JE, Romero G, Huang LC, Zhang C, Larner J: Insulin mediators are the signal transduction system responsible for insulin’s actions on human placental steroidogenesis. Endocrinology 129: in press (December 1991)
  • 60
    • 0021320117 scopus 로고
    • Somatomedin/insulin-like growth factor tissue receptors
    • Nissley S.P. Rechler M.M. Somatomedin/insulin-like growth factor tissue receptors Clin Endocrinol Metab 13 1984 43
    • (1984) Clin Endocrinol Metab , vol.13 , pp. 43
    • Nissley, S.P.1    Rechler, M.M.2
  • 61
    • 0021181906 scopus 로고
    • Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood
    • Orentreich N. Brind J.L. Rizer R.L. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood J Clin Endocrinol Metab 59 1984 551
    • (1984) J Clin Endocrinol Metab , vol.59 , pp. 551
    • Orentreich, N.1    Brind, J.L.2    Rizer, R.L.3
  • 62
    • 0022910337 scopus 로고
    • Serum bioavailability of sex steroid hormones
    • Pardridge W.M. Serum bioavailability of sex steroid hormones Clin Endocrinol Metab 15 1986 259
    • (1986) Clin Endocrinol Metab , vol.15 , pp. 259
    • Pardridge, W.M.1
  • 63
    • 0013049728 scopus 로고
    • Control of adrenal androgen secretion
    • Parker L. Lifrak E. Shively J. Control of adrenal androgen secretion Lardy H. Stratman F. Hormones, Thermogenesis, and Obesity 1989 Elsevier New York 355
    • (1989) , pp. 355
    • Parker, L.1    Lifrak, E.2    Shively, J.3
  • 64
    • 0020558682 scopus 로고
    • Insulin resistance in patients with polycystic ovaries: Its relationship to body weight and androgen levels
    • Pasquali R. Casimirri F. Venturoli S. Insulin resistance in patients with polycystic ovaries: Its relationship to body weight and androgen levels Acta Endocrinol (Copenh) 104 1983 110
    • (1983) Acta Endocrinol (Copenh) , vol.104 , pp. 110
    • Pasquali, R.1    Casimirri, F.2    Venturoli, S.3
  • 65
    • 0022620748 scopus 로고
    • Effect of weight loss and antiandrogenic therapy on sex hormone blood levels and insulin resistance in obese patients with polycystic ovaries
    • Pasquali R. Fabbri R. Venturoli S. Effect of weight loss and antiandrogenic therapy on sex hormone blood levels and insulin resistance in obese patients with polycystic ovaries Am J Obstet Gynecol 154 1986 139
    • (1986) Am J Obstet Gynecol , vol.154 , pp. 139
    • Pasquali, R.1    Fabbri, R.2    Venturoli, S.3
  • 66
    • 0024356073 scopus 로고
    • The relationship of insulin to sex hormone binding globulin: Role of adiposity
    • Peiris A.N. Sothmann M.S. Aiman E.J. The relationship of insulin to sex hormone binding globulin: Role of adiposity Fertil Steril 52 1989 69
    • (1989) Fertil Steril , vol.52 , pp. 69
    • Peiris, A.N.1    Sothmann, M.S.2    Aiman, E.J.3
  • 67
    • 0024318671 scopus 로고
    • Decreased 34K insulin-like growth factor binding protein in polycystic ovarian disease
    • Pekonen F. Laatikainen T. Buyalos R. Decreased 34K insulin-like growth factor binding protein in polycystic ovarian disease Fertil Steril 51 1989 972
    • (1989) Fertil Steril , vol.51 , pp. 972
    • Pekonen, F.1    Laatikainen, T.2    Buyalos, R.3
  • 69
    • 0023809454 scopus 로고
    • Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin
    • Plymate S.R. Matej L.A. Jones R.E. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin J Clin Endocrinol Metab 67 1988 460
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 460
    • Plymate, S.R.1    Matej, L.A.2    Jones, R.E.3
  • 71
    • 0023336845 scopus 로고
    • The gonadotropic function of insulin
    • Poretsky L. Kalin M.F. The gonadotropic function of insulin Endocr Rev 8 1987 132
    • (1987) Endocr Rev , vol.8 , pp. 132
    • Poretsky, L.1    Kalin, M.F.2
  • 72
    • 0022406388 scopus 로고
    • Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary
    • Poretsky L. Grigorescu F. Seibel M. Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary J Clin Endocrinol Metab 61 1985 728
    • (1985) J Clin Endocrinol Metab , vol.61 , pp. 728
    • Poretsky, L.1    Grigorescu, F.2    Seibel, M.3
  • 73
    • 0025299851 scopus 로고
    • Type I insulin-like growth factor receptors in human ovarian stroma
    • Poretsky L. Bhargava G. Levitan E. Type I insulin-like growth factor receptors in human ovarian stroma Horm Res 33 1990 22
    • (1990) Horm Res , vol.33 , pp. 22
    • Poretsky, L.1    Bhargava, G.2    Levitan, E.3
  • 74
    • 0025073226 scopus 로고
    • Regulation of human ovarian insulin receptors in vivo
    • Poretsky L. Bhargava G. Saketos M. Regulation of human ovarian insulin receptors in vivo Metabolism 39 1990 161
    • (1990) Metabolism , vol.39 , pp. 161
    • Poretsky, L.1    Bhargava, G.2    Saketos, M.3
  • 75
    • 0024441282 scopus 로고
    • Regulation of steroid synthesis and metabolism by growth factors
    • Reed M.J. James V.H.T. Regulation of steroid synthesis and metabolism by growth factors Clin Endocrinol (Oxf) 31 1989 511
    • (1989) Clin Endocrinol (Oxf) , vol.31 , pp. 511
    • Reed, M.J.1    James, V.H.T.2
  • 76
    • 0022386164 scopus 로고
    • Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: Pediatric perspective and natural history
    • Richards G.E. Cavallo A. Meyer W.J. III Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: Pediatric perspective and natural history I Pediatr 107 1985 893
    • (1985) I Pediatr , vol.107 , pp. 893
    • Richards, G.E.1    Cavallo, A.2    Meyer, W.J.3
  • 77
    • 0025195368 scopus 로고
    • Dysregulation of cyctochrome P450cl7a as the cause of polycystic ovary syndrome
    • Rosenfield R.L. Barnes R.B. Cara J.F. Dysregulation of cyctochrome P450cl7a as the cause of polycystic ovary syndrome Fertil Steril 53 1990 785
    • (1990) Fertil Steril , vol.53 , pp. 785
    • Rosenfield, R.L.1    Barnes, R.B.2    Cara, J.F.3
  • 78
    • 0019483909 scopus 로고
    • Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man
    • Rowe J.W. Young J.B. Minaker K.L. Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man Diabetes 30 1981 219
    • (1981) Diabetes , vol.30 , pp. 219
    • Rowe, J.W.1    Young, J.B.2    Minaker, K.L.3
  • 79
    • 0024538169 scopus 로고
    • On the regulation of sex-hormone-binding globulin—a challenge of an old dogma and outlines of an alternative mechanism
    • von Schoultz B. Carlström K. On the regulation of sex-hormone-binding globulin—a challenge of an old dogma and outlines of an alternative mechanism J Steroid Biochem 32 1989 327
    • (1989) J Steroid Biochem , vol.32 , pp. 327
    • von Schoultz, B.1    Carlström, K.2
  • 80
    • 0021355307 scopus 로고
    • Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12
    • Seppälä M. Wahlstrom T. Kosimies A.I. Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12 J Clin Endocrinol Metab 58 1984 505
    • (1984) J Clin Endocrinol Metab , vol.58 , pp. 505
    • Seppälä, M.1    Wahlstrom, T.2    Kosimies, A.I.3
  • 82
    • 0021227222 scopus 로고
    • The influence of androgens on insulin resistance
    • Shoupe D. Lobo R.A. The influence of androgens on insulin resistance Fertil Steril 41 1984 385
    • (1984) Fertil Steril , vol.41 , pp. 385
    • Shoupe, D.1    Lobo, R.A.2
  • 83
    • 0023223240 scopus 로고
    • Androgen and insulin response to an oral glucose challenge in hyperandrogenic women
    • Smith S. Ravnikar V.A. Barbieri R.L. Androgen and insulin response to an oral glucose challenge in hyperandrogenic women Fertil Steril 48 1987 72
    • (1987) Fertil Steril , vol.48 , pp. 72
    • Smith, S.1    Ravnikar, V.A.2    Barbieri, R.L.3
  • 84
    • 0022641765 scopus 로고
    • Insulin resistance with acanthosis nigricans: The roles of obesity and androgen excess
    • Stuart C.A. Peters E.I. Prince M.J. Insulin resistance with acanthosis nigricans: The roles of obesity and androgen excess Metabolism 35 1986 197
    • (1986) Metabolism , vol.35 , pp. 197
    • Stuart, C.A.1    Peters, E.I.2    Prince, M.J.3
  • 85
    • 0023269432 scopus 로고
    • Hyperinsulinemia and hyperandrogenemia: in vivo response to insulin infusion
    • Stuart C.A. Prince N.J. Peters E.J. Hyperinsulinemia and hyperandrogenemia: in vivo response to insulin infusion Obstet Gynecol 69 1987 921
    • (1987) Obstet Gynecol , vol.69 , pp. 921
    • Stuart, C.A.1    Prince, N.J.2    Peters, E.J.3
  • 86
    • 0023830896 scopus 로고
    • Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein
    • Suikkari A.-M. Koivisto V.A. Rutanen E.-M. Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein J Clin Endocrinol Metab 66 1988 266
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 266
    • Suikkari, A.-M.1    Koivisto, V.A.2    Rutanen, E.-M.3
  • 87
    • 0024559974 scopus 로고
    • Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease
    • Suikkari A.-M. Ruutiainen K. Erkkola R. Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease Hum Reprod 4 1989 136
    • (1989) Hum Reprod , vol.4 , pp. 136
    • Suikkari, A.-M.1    Ruutiainen, K.2    Erkkola, R.3
  • 88
    • 0020454343 scopus 로고
    • Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor
    • Taylor S.I. Dons R.F. Hernandez E. Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor Ann Intern Med 97 1982 851
    • (1982) Ann Intern Med , vol.97 , pp. 851
    • Taylor, S.I.1    Dons, R.F.2    Hernandez, E.3
  • 89
    • 0021013427 scopus 로고
    • Mechanisms subserving the trophic actions of insulin on ovarian cells
    • Veldhuis J.D. Kolp L.A. Toaff M.E. Mechanisms subserving the trophic actions of insulin on ovarian cells J Clin Invest 72 1983 1046
    • (1983) J Clin Invest , vol.72 , pp. 1046
    • Veldhuis, J.D.1    Kolp, L.A.2    Toaff, M.E.3
  • 90
    • 0022515922 scopus 로고
    • Insulin regulates low-density lipoprotein binding and degradation by swine granulosa cells
    • Veldhuis J.D. Nestler J.E. Strauss J.F. III Insulin regulates low-density lipoprotein binding and degradation by swine granulosa cells Endocrinology 118 1986 2242
    • (1986) Endocrinology , vol.118 , pp. 2242
    • Veldhuis, J.D.1    Nestler, J.E.2    Strauss, J.F.3
  • 91
    • 0023001697 scopus 로고
    • The insulin-like growth factor, somatomedin C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells
    • Veldhuis J.D. Rodgers R.J. Dee A. The insulin-like growth factor, somatomedin C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells J Biol Chem 261 1986 2499
    • (1986) J Biol Chem , vol.261 , pp. 2499
    • Veldhuis, J.D.1    Rodgers, R.J.2    Dee, A.3
  • 92
    • 0018840897 scopus 로고
    • The polycystic ovary syndrome
    • Yen S.C.C. The polycystic ovary syndrome Clin Endocrinol (Oxf) 12 1980 177
    • (1980) Clin Endocrinol (Oxf) , vol.12 , pp. 177
    • Yen, S.C.C.1
  • 93
    • 0023886838 scopus 로고
    • Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing
    • Yoshimasa Y. Seino S. Whittaker J. Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing Science 240 1988 784
    • (1988) Science , vol.240 , pp. 784
    • Yoshimasa, Y.1    Seino, S.2    Whittaker, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.