New technique for uncoupling the cleavage and religation reactions of Eukaryotic Topoisomerase I. The mode of action of camptothecin at a specific recognition site

Journal of Molecular Biology

Volumn 222, Issue 3, 1991, Pages 669-678

  Svejstrup, Jesper Q ^a   Christiansen, Kent ^a   Gromova, Irina I ^a   Andersen, Anni H ^a   Westergaard, Ole ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

camptothecin; cleavage and religation reaction; DNA topoisomerase I; suicide DNA substrate

Indexed keywords

CALCIUM ION; CAMPTOTHECIN; COPPER ION; DNA TOPOISOMERASE; MAGNESIUM ION; SODIUM CHLORIDE; ZINC;

ARTICLE; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BINDING SITES; CAMPTOTHECIN; CATIONS, DIVALENT; DNA; DNA TOPOISOMERASES, TYPE I; DNA, SINGLE-STRANDED; EUKARYOTIC CELLS; HUMAN; SODIUM CHLORIDE; SUPPORT, NON-U.S. GOV'T;

EID: 0026351183     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(91)90503-X     Document Type: Article

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