Chemotherapy of the acquired immune deficiency syndrome (AIDS): Acyclic nucleoside phosphonate analogues

International Journal of Immunopharmacology

Volumn 13, Issue SUPPL. 1, 1991, Pages 91-98

  De Clercq, Erik ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; ADEFOVIR; ANTIVIRUS AGENT; CIDOFOVIR; NUCLEOSIDE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; CONFERENCE PAPER; DNA SYNTHESIS; EXPERIMENTAL INFECTION; HEPATITIS B VIRUS; HERPES VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOUSE; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; RAT; RETROVIRUS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADENINE; ANTIVIRAL AGENTS; CYTOSINE; DNA, VIRAL; HUMAN; ORGANOPHOSPHORUS COMPOUNDS;

EID: 0026346379     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/0192-0561(91)90130-Y     Document Type: Article

References (34)

1. 5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)-adenine directly to their antivirally active diphosphate derivatives
2. Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine a potent anti-human immunodeficiency virus compound
3. 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines a class of highly selective antiretroviral agents in vitro and in vivo
4. Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered
5. Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine a selective anti-human immunodificiency virus agent
6. 9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys
7. Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3′-azido-2′ 3′-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus
8. Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS
9. Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents
10. Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines
11. Antiviral activity spectrum of nucleoside and nucleotide logues
12. Efficacy of (S-1-(3-hydroxy-2-phophonylmethoxypropyl)cytosine) in various models of herpes simplex virus infection in mice
13. Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccina infections in vivo
14. A novel selective broad-spectrum anti-DNA virus agent
15. Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines
16. Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine
17. Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease
18. 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
19. Treatment of latent rabbit and human papillomavirus infections with 9-(2-phosphonylmethoxy)ethylguanine (PMEG)
20. Activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) against guinea pig cytomegalovirus infection in cultured cells and in guinea pigs
21. Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication
22. Inhibitory effects of acyclic nucleoside phosphonate analogs including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine on Epstein-Barr virus replication
23. (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine in the therapy of thymidine kinase-positive and -deficient herpes simplex virus experimental keratitis
24. − HSV-1 keratitis in rabbits
25. Efficacy of (S)-HPMPA against thymidine kinase-deficient herpes simplex virus-keratitis
26. Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-26-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo
27. 9-(2-Phosphonylmethoxyethyl)-26-diaminopurine (PMEDAP) a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo
28. Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(13-dihydroxy-2-propoxymethyl)guanine (DHPG)
29. Phosphonylmethoxyethyl purine derivatives a new class of anti-human immunodeficiency virus agents
30. (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine a potent and selective inhibitor of human cytomegalovirus replication
31. Comparative activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) and 9-(13-dihydroxy-2-propoxymethyl)guanine (DHPG) against rat cytomegalovirus infection in vitro and in vivo
32. Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and inhibition of viral DNA synthesis
33. Comparative activities of several nucleoside analogs against duck hepatitis B virus in vitro
34. Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis