Synthesis and Biological Activities of New 1,4-Benzothiazine Derivatives

Chemical and Pharmaceutical Bulletin

Volumn 39, Issue 11, 1991, Pages 2888-2895

  Kajino, Masahiro ^a   Mizuno, Katsutoshi ^a   Tawada, Hiroyuki ^a   Kanji, Meguro ^a   Shibouta, Yumiko ^a   Nishikawa, Kohei ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

1,4 benzothiazine; antihypertensive activity; calmodulin antagonist; intracellular calcium antagonist; piperazine

Indexed keywords

2 [3 [4 (4 FLUOROPHENYL) 1 PIPERAZINYL]PROPYL] 5 METHYL 2H 1,4 BENZOTHIAZIN 3(4H) ONE; 3 (2 BENZOTHIAZOLYL) 4,5 DIMETHOXY N [3 (4 PHENYLPIPERIDYL)PROPYL]BENZENESULFONAMIDE; ANTIHYPERTENSIVE AGENT; BENZOTHIAZINE DERIVATIVE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; PHOSPHODIESTERASE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM ANTAGONISM; DRUG SYNTHESIS; ENZYME INHIBITION; HYPERTENSION; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; RAT; VASODILATATION;

ANIMAL; ANTIHYPERTENSIVE AGENTS; CALCIUM CHANNEL BLOCKERS; CALMODULIN; IN VITRO; MALE; PIPERAZINES; RABBITS; RATS; RATS, INBRED SHR; THIAZINES;

EID: 0026345727     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.39.2888     Document Type: Article

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