Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

Pharmacology and Therapeutics

Volumn 51, Issue 2, 1991, Pages 155-194

  Meister, Alton ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ANTINEOPLASTIC AGENT; BUTHIONINE SULFOXIMINE; CYSTEINE; FREE RADICAL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL MODEL; ANIMAL TISSUE; CANCER CHEMOTHERAPY; CATARACT; DNA METABOLISM; DRUG METABOLISM; DRUG RESISTANCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW;

ANIMAL; GLUTATHIONE; MICE; MITOCHONDRIA; NEOPLASMS; RATS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026343403     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(91)90076-X     Document Type: Review

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4. Hepatic-mediated elevation and maintenance of metastatic tumor cell glutathione
5. Elevation of glutathione in phenylalanine mustard-resistant murine L1210 leukemia cells
6. Function of γ-glutamyl transpeptidase
7. Pharmacokinetics of intravenously administered glutathione in the rat
8. Inhibition and enhancement of microsomal drug metabolism by diethyl maleate
9. Dynamic state of glutathione in blood plasma
10. Transport and direct utilization of γ-glutamylcyst(e)ine for glutathione synthesis
11. Inhibition of γ-glutamyl transpeptidase and glutathionuria produced by γ-glutamyl amino acids
12. Intracellular delivery of cysteine
13. Marked increase of cysteine levels in many regions of brain after administration of 2-oxothiazolidine-4-carboxylate
14. Glutathione monoesters
15. Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves γ-glutamyl transpeptidase
16. Glutathione monoethyl ester; preparation, uptake by tissues, and conversion to glutathione
17. Glutathione metabolism at the blood-cerebrospinal fluid barrier
18. Protection against cisplatin toxicity by administration of glutathione ester
19. The occurrence of cystinylglycine in blood plasma
20. Glutathione depletion sensitizes tumor cells to oxidative cytolysis
21. Relationship between intracellular glutathione levels and hypoxic cell radiosensitivity
22. Comparison of nitrogen-mustard-sensitive and -resistant Yoshida sarcomas
23. Glutathione efflux from perfused rat liver and its relation to glutathione uptake by the kidney
24. Ueber bromphenyl-mercaptursaure
25. Diurnal variation in mouse and rat liver sulfhydryl
26. Alloxan diabetes and the lens
27. Glutathione biosynthesis in the isolated perfused rat lung: Utilization of extracellular glutathione
28. Active transport of glutathione disulfide from erythrocytes
29. Symposium: Thiols, The role of thiols in cellular response to radiation and drugs
30. Nonprotein thiols and the radiation response of A549 human lung carcinoma cells
31. The effect of l-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells
32. Erhöhung der Chemosensitivität gegenüber cisplatin durch glutathion-depletion mit buthionin sulfoximin. In vitro- und in-vivo-untersuchungen an einer humanen plattenpithelkarzinomlinie
33. Specificity of amino acid acylases
34. Quantitative nutritional studies with water-soluble, chemically defined diets. III. Individual amino acids as sources of “non-essential” nitrogen
35. The synthesis of glutathione in isolated liver
36. An enzyme from rat liver catalysing conjugations with glutathione
37. The oxidation of ascorbic acid and its reduction in vitro and in vivo
38. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
39. The cellular production of hydrogen peroxide
40. γ-Glutamyl amino acids; Transport and conversion to 5-oxoproline in kidney
41. Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells
42. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo
43. Stimulation of rat hepatic microsomal heme oxygenase by diethyl maleate
44. Tumor sulphydryl levels and sensitivity to the nitrogen mustard merophan
45. Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice
46. Long-term home use of acetylcysteine in chronic bronchitis
47. Depletion of cellular glutathione by N,N′-bis-(trans-4-hydroxycyclohexyl)-N′-nitrosurea as a determinant of sensitivity of K562 human leukemia cells to 4-hydroxyperoxycyclophosphamide
48. Session II: Keynote Address, Thiol-induced biochemical modification of chemo- and radio-responses
49. Blood-brain barrier restriction of enkephalins
50. Glutathione reductase of wheat germ
51. Enzymic formation of pyrrolidine carboxylic acid from γ-glutamyl peptides
52. Protection against the toxicity of alkylating agents by thiols: The mechanism of protection and its relevance to cancer chemotherapy. A review
53. Enzymatic reactions of methionine sulfoximine, conversion to the corresponding α-imino and α-keto acids, and to α-ketobutyrate and methane sulfinimide
54. On the chemistry and biochemistry of 3-mercaptopyruvic acid, the α-keto acid analog of cysteine
55. Glutathione and γ-glutamyl cycle enzymes in crypt and villus tip cells of rat jejunal mucosa
56. Effect of diethyl-maleate and other glutathione depletors on protein synthesis
57. Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems
58. No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid
59. The pulmonary effects of buthionine sulfoximine treatment and glutathione depletion in rats
60. Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide
61. Interorgan flux of glutathione
62. An enzyme concerned with the formation of hydroxy acids from ketonic anhydrides
63. On glyoxalase
64. Glyoxalase. Part III. The distribution of the enzyme and its relation to the pancreas
65. 3he replacement by thiazolidinecarbozylic acid of exogenous cysteine and cysteine
66. Importance and regulation of hepatic glutathione
67. Glutathione metabolism in cultured Sertoli cells and spermatogenic cells from hamsters
68. Regulation of cellular glutathione
69. Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia
70. Sur un corps d'origine organique hydrogenant le soufre a froid
71. Nouvelles recherches physiologiques sur la substance organique hydrogenant le soufre a froid
72. Toxic effects of extended glutathione depletion by buthionine sulfoximine on murine mammary carcinoma cells
73. Glutathione export by human lymphoid cells: Depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation
74. Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes
75. Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones
76. 14-glycine
77. The effects of buthionine sulphoximine on glutathione depletion and xenobiotic biotransformation
78. Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multi-drug resistant human breast tumor cells
79. Blood and liver glutathione during protein deprivation
80. Transport of glutathione across the small intestine of the rat in vitro
81. Rate of buthionine sulfoximine entry into brain and xenotransplanted human gliomas
82. Extraction of glutathione by the isolated perfused rabbit kidney
83. Superoxide radical and hydrogen peroxide in mitochondria
84. Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion
85. Uptake of glutathione by mitochondria
86. Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice
87. Glutathione status, glutathione monoisopropyl ester
88. Passage of intact peptide across the intestine
89. 1-Amino-1,3-dicarboxycyclohexane (cyclogutamic acid): A new glutamic acid analog and a substrate of glutamine synthetase
90. Computer Analysis of the Active Site of Glutamine Synthetase
91. Influence of a cysteine prodrug, l-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromethane, and acrylonitrile: a dose-effect study
92. Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion
93. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis
94. Glutathione and cell survival
95. l-Buthionine-SR-sulfoximine: Mechanism of action, resolution of diastereomers and use as a chemotherapeutic agent
96. Differential inhibition of glutamine and γ-glutamycysteine synthetases by α-alkyl analogs of methionine sulfoximine that induce convulsions
97. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
98. Translocation of intracellular glutathione to membrane-bound γ glutamyl transpeptidase as a discrete step in the γ-glutamyl cycle; Glutathionuria after inhibition of transpeptidase
99. Glutathione: Interorgan translocation, turnover and metabolism
100. Excretion of cysteine and γ-glutamyclysteine moieties in human and experimental animal γ-glutamyl transpeptidase deficiency
101. Origin and turnover of mitochondrial glutathione
102. Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl-homocysteine sulfoximine) a selective inhibitor of γglutamylcysteine synthetase
103. Formation of γglutamylcyst(e)ine in vivo is catalyzed by γ-glutamyl transpeptidase
104. Thiol groups of biological importance
105. Assessment of the kidney function in maintenance of plasma glutathione concentration and redox state in anesthetized rats
106. Transepithelial transport of glutathione in vascularly perfused small intestine of rat
107. Role of glutathione transport in extrahepatic detoxication
108. Bioavailability of dietary glutathione: Effect on plasma concentration
109. The fate of extracellular glutathione in the rat
110. Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice
111. Augmentation of Adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion
112. Phase I trial of buthionine sulfoximine (BSO) plus melphalan (L-PAM) in patients with advanced cancer
113. Synthesis of peptides in enzymatic reactions involving glutathione
114. Experimental production of renal glycosuria, phosphaturia, and aminoaciduria by injection of maleic acid
115. Mechanism of natural and acquired resistance to methyl-bis-(β-chlorethyl)-amine N-oxide in ascites tumors
116. XXXII On an autoxidisable constituent of the cell
117. CCV Some relations between ascorbic acid and glutathione
118. LXXXI The influence of thiol-groups in the activity of dehydrogenases
119. Evidence for impairment of transsulfuration pathway in cirrhosis
120. Absorption of glutathione from the gastro-intestinal tract
121. Direct evidence for the role of the membrane potential in glutathione transport by renal brush-border membranes
122. The mechanisms of biliary secretion of reduced glutathione. Analysis of transport process in isolated rat-liver canalicular membrane vesicles
123. Biliary transport of glutathione S-conjugate by rat liver canalicular membrane veiscles
124. Mechanism of renal peritubular extraction of plasma glutathione. The catalytic activity of contralumenal γ-glutamyl-transferase is prerequisite to the apparent peritubular extraction of plasma glutathione
125. Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice
126. Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice
127. Enhancement of cisplatin toxicity by buthionine sulfoximine, a glutathione-depleting agent, in mice
128. 2+-dependent cardiac transport system for glutathione S-conjugates
129. Diuranal variation of hepatic glutathione concentration and its correlation with 1,1-dichloroethylene inhalation toxicity in rats
130. Ueber die nach einfuhrung von brombenzol und chlorbenzol in organismus entstehenden schwefelhatigen sauren
131. Glutathione deficiency leads to mitochondrial damage in brain
132. Radioprotection of human lymphoid cells by exogenously-supplied glutathione is mediated by γ-glutamyl transpeptidase
133. Some properties of mitochondrial glutathione
134. The non-protein thiol of rat liver mitochondria
135. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo
136. Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat
137. Modulation of glutathione level in cultured human melanoma cells
138. Morphological changes in rat brain induced by l-cysteine injection in newborn animals
139. Direct evidence of intecellular sharing of glutathione via metabolic cooperation
140. Studies on the crystalline lens
141. Lest I forget thee, glutathione…
142. Chemosensitization of l-phenylalanine mustard by the thiol-modulating agent buthionine sulfioximine
143. Session VII. The effect of glutathione depletion in vivo by buthionine sulfoximine on the radiosensitization of SR 2508
144. Transport of glutathione across the mitochondrial membranes
145. Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines
146. Renal Glutathione Transport. Characteristics of the sodium-dependent system in the basal-lateral membrane
147. Oxidative stress in isolated rat renal proximal and distal tubular cells
148. Exogenous glutathione protects intestinal epithelial cells from oxidative injury
149. Depletion of tumor versus normal tissue glutathione by buthionine sulfoximine
150. Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer—a possible indicator of chemosensitivity
151. The effect of glutathione on the vitamine E requirement for inhibition of liver microsomal lipid peroxidation
152. Radiation response of drug-resistant variants of a human breast cancer cell line: The effect of glutathione depletion
153. Spermatogenic cell-somatic cell interactions are required for maintenance of spermatogenic cell glutathione
154. Transport of glutathione by intestinal brush border membrane vesicles
155. DDT dehydrochlorinase. I. Isolation, chemical properties, and spectrophotometric assay
156. l-Buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice
157. A study of the enzymic transformation of synthetic methylglyoxal to lactic acid
158. 2 production in pigeon heart mitochondria
159. Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells
160. British Thoracic Society Research Committee Report, Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction
161. N-Formylcysteine synthesis in mitochondria from formaldehyde and l-cysteine via thiazolidinecarboxylic acid
162. Effects of glutathione and glutathione isopropyl ester on vasospasm in subarachnoid hemorrhage
163. Identification of l-methionine-S-sulfoximine as the diastereoisomer of l-methionine-SR-sulfoximine that inhibits glutamine synthetase
164. The reduction of glutathione by plant tissues
165. Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione mono ester
166. Glutathione deficiency decrease tissue ascorbate levels in newborn rats; ascorbate spares glutathione and protects
167. Glutathione metabolism in the lung: Inhibition of its synthesis leads to lamellar body and mitochondrial defects
168. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage
169. Glutathione is required for intestinal function
170. High affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function
171. Peptide transport: The concept and its development
172. Promotion of trans-plantinum in vivo effects on renal heme and hemo-protein metabolism by d,l-buthionine-S,R-sulfoximine
173. Effect of glutathione depletion on morphine toxicity in mice
174. The interorgan metabolism of glutathione
175. The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line
176. The specificity of glutamine synthetase and its relationship to substrate conformation at the active site
177. On the enzymology of amino acid transport
178. Glutathione synthesis
179. Glutamine synthetase of mammals
180. Inhibition of glutamine synthetase and γ glutamylcysteine synthetase by methionine sulfoximine and related compounds
181. Current status of the γ-glutamyl cycle
182. Selective modification of glutathione metabolism
183. Metabolism and transport of glutathione and of other γ-glutamyl compounds
184. Methods for selective modification of glutathione metabolism and study of glutathione transport
185. The fall and rise of cellular glutathione levels: Enzyme-based approaches
186. Modulation of intracellular levels of glutathione
187. Novel drugs that affect glutathione metabolism
188. Glutathione metabolism and its selective modification
189. A brief history of glutathione and a survey of its metabolism and functions
190. Metabolism and function of glutathione
191. On the biochemistry of glutathione
192. Glutathione
193. Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione; Possible chemotherapeutic implications
194. Effect of buthionine sulfoximine and related compounds on mitochondrial glutathione levels
195. Glutathione synthetase deficiency and other disorders of the γ-glutamyl cycle
196. Intracellular cysteine and glutathione delivery systems
197. Status of the mitochondrial pool of glutathione in the isolated hepatocyte
198. Administration of l-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain
199. Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown
200. Glutathione depletion in tissues after administration of buthionine sulphoximine
201. Mechanism of action of paracetamol protective agents in mice in vivo
202. Historical aspects of glutathione and chemotherapy
203. The role of glutathione in radiation and drug induced cytotoxicity
204. Role of glutathione and other endogenous thiols in radiation protection
205. Keynote address: Glutathione modulation in cancer treatment: Will it work?
206. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism
207. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione
208. Inactivation of γ-glutamylcysteine synthetase, but not of glutamine synthetase,by S-sulfocysteine and S-sulfohomocysteine
209. Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: A possible model for mammalian cell protection
210. Disorders of transsulfuration
211. Cellular glutathione is a determinant of sensitivity to mercuric chloride toxicity Prevention of toxicity by giving glutathione monoester
212. Prodrugs of l-cystein as liver protective agents.2(RS)-methylthiazolidine-4(R)-carboxylic acid, a latent cysteine
213. 2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of l-cystein. Protection of mice against acetaminophen hepatotoxicity
214. Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis
215. Uber die zerstorung von milchsaurealdehyd und methylglyoxal durch tierische organe
216. Regeneration of vitamin E from α-chromanoxyl radical by glutathione and vitamin C
217. Cytotoxicity of cysteine in culture media
218. Effects of glutathione isopropyl ester on glutathione concentration in ischemic rat brain
219. Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system
220. The γ-Glutamyl cycle; A possible transport system for amino acids
221. Partial reactions catalyzed by γ-glutamylcysteine synthetase and evidence for an activated glutamate intermediate
222. Translocation of amino acids and glutathione studies with the perfused kidney and isolated renal cells
223. Glutathione depletion with buthionine sulfoximine: Potential clinical applications
224. Manipulation of cellular thiols to influence drug resistance
225. Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione
226. Direct observation of a free radical interaction between vitamin E and vitamin C
227. Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats
228. Resistance to alkylating agents and cisplatin: Insights from ovarian carcinoma model systems
229. Session VII. Modification of SR 2508 sensitization in hypoxic V79 cells by manipulation of glutathione levels
230. Marked reduction of rat brain glutathione following intracerebroventricular administration of the glutathione synthesis inhibitor l-buthionine sulfoximine
231. Intracerebroventricular administration of l-buthionine sulfoximine: A method for depleting brain glutathione
232. Reduction of brain glutathione by l-buthionine sulfoximine potentiates the dopamine-depletion action of 6-hydroxydopamine in rat striatum
233. Reversal of experimental paracetamol toxicosis with N-acetylcysteine
234. Chemical depletion of glutathione in vivo
235. Acetaminophen-induced hepatic necrosis. III. Cytochrome P-450-mediated covalent binding in vitro
236. Transport of glutathione as γ-glutalcysteinylglycyl ester, into liver and kidney
237. Hepatic efflux and renal extraction of plasma glutathione: Marked differences between healthy subjects and the rat
238. In vivo formation of methionine sulfoximine phosphate, a protein-bound metabolite of methionine sulfoximine
239. The action of formaldehyde upon cysteine
240. Vitamin E dependent reduced glutathione inhibition of rat liver microsomal lipid peroxidation
241. Chemically-induced glutathione depletion and lipid peroxidation
242. Regulation of γ-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione
243. Inhibition of γ-glutamylcysteine synthetase by l-methionine-S-sulfoximine
244. Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin
245. Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine
246. Subcellular glutathione contents in isolated hepatocytes treated with l-buthionine sulfoximine
247. Phosphorylation of methionine sulfoximine by glutamine synthetase
248. Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine
249. Maleic acid-induced inhibition of amino acid transport in rat kidney
250. Identification of l-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine
251. Inhibition of glutamine synthetase by methionine sulfoximine; Studies on methionine sulfoximine phosphate
252. Session I. Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels
253. Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation
254. The effects of cellular glutathione elevation on the oxygen enhancement ratio
255. Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs
256. Session II. In vivo modulation of glutathione by buthionine sulfoximine: Effect on marrow response to melphalan
257. Effect of an altered glutathione content on renal ischemic injury
258. Compounds of thiol acids with aldehydes
259. Glutathione turnover in the kidney; Considerations relating to the γ-glutamyl cycle and the transport of amino acids
260. Covalent interaction of l-2-amino-4-oxo-5-chloropentanoate at the glutamate binding site of γ-glutamylcysteine synthetase
261. The in vitro reduction in viscosity of human tracheo-bronchial secretions by acetylcysteine
262. Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro
263. Interaction of the d-isomer of γ-methylene glutamate with an active site thiol of γ-glutamylcysteine synthetase
264. Glutathione, A first line of defense against cadmium toxicity
265. Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medullo-blastoma xenograft in athymic mice
266. Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenograft
267. Depletion of brain glutathione in preweanling mice by l-buthionine sulfoximine
268. Glutathione catabolism by the ischemic rat kidney
269. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the National multicenter study (1976 to 1985)
270. Pharmacokinetic of buthonine sulfoximine (NSC 326231) and its effect on melphalan-induced toxicity in mice
271. 2 insult
272. Transport into brain of buthionine sulfoximine. An inhibitor of glutathione synthesis, is facilitated by esterification and administration of dimethylsulfoxide
273. Methionine metabolism in developing neural tissue
274. Effects of the long-term depletion of reduced glutathione in mice administered l-buthionine-S,R-sulfoximine
275. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens
276. Reduction in glutathione content of L-PAM resistant L1210 cells confers drug sensitivity
277. Dechlorination of l-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content
278. CLXXIII. Observations on the function of peroxidase systems and the chemistry of the adrenal cortex. Description of a new carbohydrate derivative
279. Identity of maleate-stimulated “glutaminase” with γ-glutamyl transpeptidase in rat kidney
280. Studies on the regulation of glutathione level in rat liver
281. Rat liver glutathione: Possible role as a reservoir of cysteine
282. Glutathione monoethyl ester can selectively protect liver from high dose BCNU or cyclophosphamide
283. Glutathione S-transferases and anticancer drug resistance
284. Utilization of l-cystine by the γ-glutamyl transpeptidase-γ-glutamyl cyclotransfrase pathway
285. Metabolic activation and hepatotoxity. Effect of cysteine, N-acetyl-ccysteine, and methionine on glutathie biosynthesis and bromobenzene toxicity in isolated rat hepatocytes
286. Modulation of endothelial GSH concentrations: Effect of exogenous GSH and GSH monoethyl ester
287. Session II. Chemosensitization by buthionine sulfoximine in vivo
288. Glutathione enhancement in various mouse organs and protection by glutathione iso propyl ester against liver injury
289. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase acticity on phosphatidylcholine hydroperoxides
290. Enzymatic conversion of 5-oxo-l-proline (l-pyrrolidone carboxylate) to l-glutamate coupled with ATP cleavage to ADP: A reaction in the γ-glutamyl cycle
291. Effect of oral glutathione on hepatic glutathione levels in rats and mice
292. Glutathione-mediated transport across intestinal brush-border membranes
293. Cytotoxicity as an indicator for transport mechanism. Evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cells
294. Cellular pharmacokinetics of the phenylalanine mustards
295. Acquired resistance of tumor cells to l-phenylalanine mustard:: Implications for the design of a clinical trial involving glutathione depletion
296. Endogenous versus exogenous thiols in radioprotection
297. Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-Stransferases
298. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E
299. Glutathione synthetase deficiency An inborn error of metabolism involving the γ-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)
300. Radioprotection by glutathione ester; transport of glutathione ester into human lymphoid cells and fibroblasts
301. Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity
302. The level and half-life of glutathione in human plasma
303. Drug-induced lipid peroxidation in mice—III Glutathione content of liver kidney and spleen after antravenous administration of free and liposomally entrapped glutathione
304. Stimulation of hepatic glutathione formation by administration of l-2-oxothiazolidine-4-carboxylate, A 5-oxo-l-prolinase substrate
305. Effect of sulfhydryl grdification on the activities of 5-oxo-l-prolinase
306. New substrates of 5-oxo-l-prolinase
307. An intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis
308. Selective effects of N-acetylcysteine stereoisomers on hepatic glutathione and plasma sulfate in mice
309. Effects of phorone (diisopropylidene acetone), a glutathione (GSH) depletor, on hepatic enzymes involved in drug and heme metabolism in rats: Evidence that phorone is a potent inducer of heme oxygenase
310. Transport of l-cysteine and reduced glutathione through biological membranes
311. Protective effect of reduced glutathione against cisplatin-induced renal and systematic toxicity and its influence on the therapeutic activity of the antitumor drug